CXCL11

 

Full name: C-X-C motif chemokine ligand 11 Alias Symbol: H174|b-R1|I-TAC|IP-9
Type: protein-coding gene Cytoband: 4q21.1
Entrez ID: 6373 HGNC ID: HGNC:10638 Ensembl Gene: ENSG00000169248 OMIM ID: 604852
Drug and gene relationship at DGIdb

 

CXCL11 involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04620Toll-like receptor signaling pathway

 

Expression of CXCL11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CXCL11 6373 211122_s_at 1.0858 0.6905
GSE20347 CXCL11 6373 210163_at 1.4199 0.0091
GSE23400 CXCL11 6373 211122_s_at 0.9659 0.0003
GSE26886 CXCL11 6373 210163_at -0.3183 0.7368
GSE29001 CXCL11 6373 210163_at 3.6539 0.0005
GSE38129 CXCL11 6373 211122_s_at 1.1237 0.0036
GSE45670 CXCL11 6373 211122_s_at 2.6945 0.0099
GSE53622 CXCL11 6373 42718 2.4257 0.0000
GSE53624 CXCL11 6373 42718 2.5761 0.0000
GSE63941 CXCL11 6373 211122_s_at 0.0875 0.9418
GSE77861 CXCL11 6373 210163_at 0.1203 0.2704
GSE97050 CXCL11 6373 A_23_P125278 1.3246 0.2874
SRP007169 CXCL11 6373 RNAseq 1.8378 0.0211
SRP133303 CXCL11 6373 RNAseq 3.8477 0.0000
SRP159526 CXCL11 6373 RNAseq 0.4769 0.4183
TCGA CXCL11 6373 RNAseq 1.7196 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by CXCL11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CXCL11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CXCL11 6373 2 9 19
GSE20123 CXCL11 6373 2 9 19
GSE43470 CXCL11 6373 0 13 30
GSE46452 CXCL11 6373 1 36 22
GSE47630 CXCL11 6373 1 19 20
GSE54993 CXCL11 6373 7 0 63
GSE54994 CXCL11 6373 0 9 44
GSE60625 CXCL11 6373 0 0 11
GSE74703 CXCL11 6373 0 11 25
GSE74704 CXCL11 6373 2 5 13
TCGA CXCL11 6373 17 30 49

Total number of gains: 32; Total number of losses: 141; Total Number of normals: 315.  

 

Somatic mutations of CXCL11:

 

Generating mutation plots.

 

Highly correlated genes for CXCL11:

 

Showing top 20/612 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CXCL11CXCL100.897313013
CXCL11CXCL90.81589812011
CXCL11EPSTI10.804289707
CXCL11USP410.803411303
CXCL11TFEC0.74547810010
CXCL11GBP10.74104612011
CXCL11RSAD20.73096313013
CXCL11PLA2G70.7260911009
CXCL11GNLY0.717845909
CXCL11GBP40.708635808
CXCL11IDO10.70772512011
CXCL11GZMB0.70615812011
CXCL11APOBEC3D0.6997303
CXCL11USP180.69833611011
CXCL11RNF2130.697276505
CXCL11UBE2L60.69562412010
CXCL11FCGR3A0.695128303
CXCL11TAP10.6941691109
CXCL11IFI440.69362113012
CXCL11ICAM10.691958707

For details and further investigation, click here