| Full name: patatin like phospholipase domain containing 3 | Alias Symbol: dJ796I17.1|FLJ22012|adiponutrin|iPLA2epsilon | ||
| Type: protein-coding gene | Cytoband: 22q13.31 | ||
| Entrez ID: 80339 | HGNC ID: HGNC:18590 | Ensembl Gene: ENSG00000100344 | OMIM ID: 609567 |
Expression of PNPLA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNPLA3 | 80339 | 233030_at | 1.2105 | 0.1185 | |
| GSE20347 | PNPLA3 | 80339 | 220675_s_at | 0.4268 | 0.0013 | |
| GSE23400 | PNPLA3 | 80339 | 220675_s_at | 0.0017 | 0.9709 | |
| GSE26886 | PNPLA3 | 80339 | 233030_at | 1.3194 | 0.0000 | |
| GSE29001 | PNPLA3 | 80339 | 220675_s_at | 0.3469 | 0.0141 | |
| GSE38129 | PNPLA3 | 80339 | 220675_s_at | 0.4090 | 0.0013 | |
| GSE45670 | PNPLA3 | 80339 | 233030_at | 1.0384 | 0.0156 | |
| GSE53622 | PNPLA3 | 80339 | 6480 | 1.1836 | 0.0000 | |
| GSE53624 | PNPLA3 | 80339 | 6480 | 2.0539 | 0.0000 | |
| GSE63941 | PNPLA3 | 80339 | 233030_at | -0.5864 | 0.3520 | |
| GSE77861 | PNPLA3 | 80339 | 233030_at | 0.2080 | 0.1031 | |
| GSE97050 | PNPLA3 | 80339 | A_23_P17914 | 0.0922 | 0.7736 | |
| SRP007169 | PNPLA3 | 80339 | RNAseq | 1.7364 | 0.0301 | |
| SRP064894 | PNPLA3 | 80339 | RNAseq | 0.6420 | 0.0060 | |
| SRP133303 | PNPLA3 | 80339 | RNAseq | 0.5715 | 0.0338 | |
| SRP159526 | PNPLA3 | 80339 | RNAseq | 1.2241 | 0.0047 | |
| SRP193095 | PNPLA3 | 80339 | RNAseq | 0.7028 | 0.0002 | |
| SRP219564 | PNPLA3 | 80339 | RNAseq | 0.3015 | 0.4562 | |
| TCGA | PNPLA3 | 80339 | RNAseq | 1.6298 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by PNPLA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNPLA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNPLA3 | 80339 | 5 | 7 | 18 | |
| GSE20123 | PNPLA3 | 80339 | 4 | 6 | 20 | |
| GSE43470 | PNPLA3 | 80339 | 3 | 6 | 34 | |
| GSE46452 | PNPLA3 | 80339 | 31 | 2 | 26 | |
| GSE47630 | PNPLA3 | 80339 | 9 | 4 | 27 | |
| GSE54993 | PNPLA3 | 80339 | 3 | 6 | 61 | |
| GSE54994 | PNPLA3 | 80339 | 11 | 8 | 34 | |
| GSE60625 | PNPLA3 | 80339 | 5 | 0 | 6 | |
| GSE74703 | PNPLA3 | 80339 | 3 | 4 | 29 | |
| GSE74704 | PNPLA3 | 80339 | 2 | 3 | 15 | |
| TCGA | PNPLA3 | 80339 | 26 | 15 | 55 |
Total number of gains: 102; Total number of losses: 61; Total Number of normals: 325.
Somatic mutations of PNPLA3:
Generating mutation plots.
Highly correlated genes for PNPLA3:
Showing top 20/543 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNPLA3 | FBRSL1 | 0.711008 | 4 | 0 | 4 |
| PNPLA3 | ADAM8 | 0.710888 | 3 | 0 | 3 |
| PNPLA3 | SCYL1 | 0.701117 | 3 | 0 | 3 |
| PNPLA3 | MNT | 0.676958 | 3 | 0 | 3 |
| PNPLA3 | GPRIN1 | 0.666365 | 4 | 0 | 4 |
| PNPLA3 | TIMM50 | 0.652704 | 4 | 0 | 3 |
| PNPLA3 | ACVR1C | 0.647926 | 4 | 0 | 3 |
| PNPLA3 | HOXC9 | 0.646276 | 4 | 0 | 4 |
| PNPLA3 | ALKBH6 | 0.643478 | 4 | 0 | 3 |
| PNPLA3 | BRAT1 | 0.63788 | 6 | 0 | 5 |
| PNPLA3 | DNAJB11 | 0.632289 | 5 | 0 | 4 |
| PNPLA3 | MSTO1 | 0.629177 | 7 | 0 | 6 |
| PNPLA3 | VANGL2 | 0.626657 | 4 | 0 | 3 |
| PNPLA3 | IGSF8 | 0.62568 | 6 | 0 | 4 |
| PNPLA3 | C4orf48 | 0.625518 | 6 | 0 | 6 |
| PNPLA3 | HAUS7 | 0.621965 | 4 | 0 | 3 |
| PNPLA3 | BEND3 | 0.619744 | 6 | 0 | 6 |
| PNPLA3 | XPO5 | 0.618056 | 6 | 0 | 5 |
| PNPLA3 | LYPD1 | 0.617837 | 5 | 0 | 4 |
| PNPLA3 | NOP58 | 0.616733 | 6 | 0 | 5 |
For details and further investigation, click here
