| Full name: G protein-coupled receptor 68 | Alias Symbol: OGR1 | ||
| Type: protein-coding gene | Cytoband: 14q32.11 | ||
| Entrez ID: 8111 | HGNC ID: HGNC:4519 | Ensembl Gene: ENSG00000119714 | OMIM ID: 601404 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR68:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR68 | 8111 | 229055_at | 0.9696 | 0.2966 | |
| GSE20347 | GPR68 | 8111 | 211249_at | -0.0292 | 0.7458 | |
| GSE23400 | GPR68 | 8111 | 211249_at | -0.0423 | 0.1136 | |
| GSE26886 | GPR68 | 8111 | 229055_at | 0.9796 | 0.0516 | |
| GSE29001 | GPR68 | 8111 | 211249_at | 0.0620 | 0.5892 | |
| GSE38129 | GPR68 | 8111 | 211249_at | 0.0549 | 0.4449 | |
| GSE45670 | GPR68 | 8111 | 229055_at | 0.8247 | 0.0097 | |
| GSE53622 | GPR68 | 8111 | 51562 | 0.6982 | 0.0002 | |
| GSE53624 | GPR68 | 8111 | 51562 | 0.9784 | 0.0000 | |
| GSE63941 | GPR68 | 8111 | 229055_at | -3.6917 | 0.0000 | |
| GSE77861 | GPR68 | 8111 | 229055_at | 0.1718 | 0.5199 | |
| GSE97050 | GPR68 | 8111 | A_24_P931443 | 0.3305 | 0.2237 | |
| SRP007169 | GPR68 | 8111 | RNAseq | 1.0337 | 0.0657 | |
| SRP008496 | GPR68 | 8111 | RNAseq | 0.7824 | 0.1577 | |
| SRP064894 | GPR68 | 8111 | RNAseq | 1.5605 | 0.0000 | |
| SRP133303 | GPR68 | 8111 | RNAseq | 0.9064 | 0.0053 | |
| SRP159526 | GPR68 | 8111 | RNAseq | -0.3210 | 0.1776 | |
| SRP193095 | GPR68 | 8111 | RNAseq | 1.1531 | 0.0000 | |
| SRP219564 | GPR68 | 8111 | RNAseq | 0.9465 | 0.0243 | |
| TCGA | GPR68 | 8111 | RNAseq | 0.3713 | 0.0084 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by GPR68 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR68:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR68 | 8111 | 9 | 5 | 16 | |
| GSE20123 | GPR68 | 8111 | 9 | 5 | 16 | |
| GSE43470 | GPR68 | 8111 | 7 | 3 | 33 | |
| GSE46452 | GPR68 | 8111 | 16 | 3 | 40 | |
| GSE47630 | GPR68 | 8111 | 11 | 8 | 21 | |
| GSE54993 | GPR68 | 8111 | 3 | 8 | 59 | |
| GSE54994 | GPR68 | 8111 | 19 | 4 | 30 | |
| GSE60625 | GPR68 | 8111 | 0 | 2 | 9 | |
| GSE74703 | GPR68 | 8111 | 6 | 3 | 27 | |
| GSE74704 | GPR68 | 8111 | 4 | 4 | 12 | |
| TCGA | GPR68 | 8111 | 30 | 21 | 45 |
Total number of gains: 114; Total number of losses: 66; Total Number of normals: 308.
Somatic mutations of GPR68:
Generating mutation plots.
Highly correlated genes for GPR68:
Showing top 20/462 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR68 | IL6 | 0.700542 | 3 | 0 | 3 |
| GPR68 | ADAM8 | 0.692792 | 6 | 0 | 5 |
| GPR68 | NTPCR | 0.682278 | 3 | 0 | 3 |
| GPR68 | ZBED6 | 0.67318 | 3 | 0 | 3 |
| GPR68 | LTBP1 | 0.668375 | 3 | 0 | 3 |
| GPR68 | CTSK | 0.667638 | 4 | 0 | 4 |
| GPR68 | RUNX1-IT1 | 0.664273 | 4 | 0 | 4 |
| GPR68 | ACSL4 | 0.658962 | 4 | 0 | 3 |
| GPR68 | TRPV2 | 0.656196 | 5 | 0 | 5 |
| GPR68 | CHST11 | 0.655358 | 6 | 0 | 5 |
| GPR68 | PTX3 | 0.654855 | 4 | 0 | 3 |
| GPR68 | AMPD3 | 0.654446 | 5 | 0 | 4 |
| GPR68 | MAP4 | 0.65432 | 5 | 0 | 4 |
| GPR68 | PCED1B | 0.648109 | 5 | 0 | 5 |
| GPR68 | CHSY3 | 0.641921 | 5 | 0 | 4 |
| GPR68 | SCG5 | 0.639128 | 5 | 0 | 4 |
| GPR68 | SIRPA | 0.636877 | 8 | 0 | 8 |
| GPR68 | ARSI | 0.63593 | 7 | 0 | 5 |
| GPR68 | CCM2 | 0.634023 | 7 | 0 | 7 |
| GPR68 | RRM1 | 0.633622 | 3 | 0 | 3 |
For details and further investigation, click here
