| Full name: myocyte enhancer factor 2A | Alias Symbol: RSRFC4|RSRFC9 | ||
| Type: protein-coding gene | Cytoband: 15q26.3 | ||
| Entrez ID: 4205 | HGNC ID: HGNC:6993 | Ensembl Gene: ENSG00000068305 | OMIM ID: 600660 |
| Drug and gene relationship at DGIdb | |||
MEF2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway |
Expression of MEF2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEF2A | 4205 | 214684_at | 0.2897 | 0.5774 | |
| GSE20347 | MEF2A | 4205 | 214684_at | 0.7242 | 0.0004 | |
| GSE23400 | MEF2A | 4205 | 214684_at | 0.6166 | 0.0000 | |
| GSE26886 | MEF2A | 4205 | 214684_at | 1.0065 | 0.0001 | |
| GSE29001 | MEF2A | 4205 | 214684_at | 0.7925 | 0.0003 | |
| GSE38129 | MEF2A | 4205 | 214684_at | 0.6879 | 0.0000 | |
| GSE45670 | MEF2A | 4205 | 214684_at | 0.9630 | 0.0000 | |
| GSE53622 | MEF2A | 4205 | 22258 | 0.1691 | 0.0299 | |
| GSE53624 | MEF2A | 4205 | 1747 | 0.0541 | 0.3141 | |
| GSE63941 | MEF2A | 4205 | 214684_at | -0.1800 | 0.7894 | |
| GSE77861 | MEF2A | 4205 | 214684_at | 0.8022 | 0.0016 | |
| GSE97050 | MEF2A | 4205 | A_33_P3341676 | -0.4200 | 0.2192 | |
| SRP007169 | MEF2A | 4205 | RNAseq | 0.3178 | 0.3062 | |
| SRP008496 | MEF2A | 4205 | RNAseq | 0.3517 | 0.1515 | |
| SRP064894 | MEF2A | 4205 | RNAseq | 0.3311 | 0.0935 | |
| SRP133303 | MEF2A | 4205 | RNAseq | 0.1475 | 0.2773 | |
| SRP159526 | MEF2A | 4205 | RNAseq | -0.0740 | 0.6971 | |
| SRP193095 | MEF2A | 4205 | RNAseq | 0.1626 | 0.0507 | |
| SRP219564 | MEF2A | 4205 | RNAseq | -0.2388 | 0.4859 | |
| TCGA | MEF2A | 4205 | RNAseq | -0.0975 | 0.0561 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MEF2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEF2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEF2A | 4205 | 7 | 2 | 21 | |
| GSE20123 | MEF2A | 4205 | 7 | 2 | 21 | |
| GSE43470 | MEF2A | 4205 | 6 | 5 | 32 | |
| GSE46452 | MEF2A | 4205 | 3 | 7 | 49 | |
| GSE47630 | MEF2A | 4205 | 9 | 10 | 21 | |
| GSE54993 | MEF2A | 4205 | 4 | 7 | 59 | |
| GSE54994 | MEF2A | 4205 | 9 | 7 | 37 | |
| GSE60625 | MEF2A | 4205 | 4 | 0 | 7 | |
| GSE74703 | MEF2A | 4205 | 5 | 4 | 27 | |
| GSE74704 | MEF2A | 4205 | 3 | 3 | 14 | |
| TCGA | MEF2A | 4205 | 18 | 12 | 66 |
Total number of gains: 75; Total number of losses: 59; Total Number of normals: 354.
Somatic mutations of MEF2A:
Generating mutation plots.
Highly correlated genes for MEF2A:
Showing top 20/1298 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEF2A | LARS2 | 0.803421 | 3 | 0 | 3 |
| MEF2A | SLC6A6 | 0.781758 | 3 | 0 | 3 |
| MEF2A | C6orf141 | 0.779121 | 3 | 0 | 3 |
| MEF2A | ANKRD11 | 0.778979 | 3 | 0 | 3 |
| MEF2A | KLHL13 | 0.777019 | 3 | 0 | 3 |
| MEF2A | ZC3H18 | 0.774877 | 3 | 0 | 3 |
| MEF2A | PHIP | 0.770517 | 3 | 0 | 3 |
| MEF2A | ZFP1 | 0.749923 | 3 | 0 | 3 |
| MEF2A | CPSF3 | 0.745955 | 5 | 0 | 5 |
| MEF2A | PHRF1 | 0.743417 | 3 | 0 | 3 |
| MEF2A | IRF2BP2 | 0.742266 | 3 | 0 | 3 |
| MEF2A | SSBP4 | 0.740864 | 3 | 0 | 3 |
| MEF2A | METTL23 | 0.735893 | 3 | 0 | 3 |
| MEF2A | EFTUD2 | 0.732076 | 4 | 0 | 4 |
| MEF2A | GAS2L1 | 0.730902 | 5 | 0 | 5 |
| MEF2A | PLXNB3 | 0.730697 | 3 | 0 | 3 |
| MEF2A | IKBIP | 0.730616 | 4 | 0 | 4 |
| MEF2A | SPTBN1 | 0.727148 | 4 | 0 | 3 |
| MEF2A | RELL1 | 0.725318 | 3 | 0 | 3 |
| MEF2A | INPP4A | 0.724767 | 4 | 0 | 4 |
For details and further investigation, click here
