| Full name: hexokinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p12 | ||
| Entrez ID: 3099 | HGNC ID: HGNC:4923 | Ensembl Gene: ENSG00000159399 | OMIM ID: 601125 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04930 | Type II diabetes mellitus |
Expression of HK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HK2 | 3099 | 202934_at | 0.8426 | 0.5568 | |
| GSE20347 | HK2 | 3099 | 202934_at | 0.6410 | 0.0103 | |
| GSE23400 | HK2 | 3099 | 202934_at | 0.6750 | 0.0003 | |
| GSE26886 | HK2 | 3099 | 202934_at | -1.0959 | 0.0136 | |
| GSE29001 | HK2 | 3099 | 202934_at | 0.5015 | 0.1890 | |
| GSE38129 | HK2 | 3099 | 202934_at | 1.0881 | 0.0016 | |
| GSE45670 | HK2 | 3099 | 202934_at | 1.0225 | 0.0006 | |
| GSE53622 | HK2 | 3099 | 66119 | 0.6417 | 0.0001 | |
| GSE53624 | HK2 | 3099 | 66119 | 0.4428 | 0.0000 | |
| GSE63941 | HK2 | 3099 | 202934_at | -2.0491 | 0.0492 | |
| GSE77861 | HK2 | 3099 | 202934_at | 0.6123 | 0.2183 | |
| GSE97050 | HK2 | 3099 | A_32_P175739 | 1.0996 | 0.1186 | |
| SRP007169 | HK2 | 3099 | RNAseq | 1.5252 | 0.0423 | |
| SRP008496 | HK2 | 3099 | RNAseq | -0.0678 | 0.7771 | |
| SRP064894 | HK2 | 3099 | RNAseq | 0.4390 | 0.3652 | |
| SRP133303 | HK2 | 3099 | RNAseq | 1.2084 | 0.0001 | |
| SRP159526 | HK2 | 3099 | RNAseq | 1.6132 | 0.0016 | |
| SRP193095 | HK2 | 3099 | RNAseq | 0.2714 | 0.1951 | |
| SRP219564 | HK2 | 3099 | RNAseq | -0.5360 | 0.5226 | |
| TCGA | HK2 | 3099 | RNAseq | 0.2054 | 0.0588 |
Upregulated datasets: 5; Downregulated datasets: 2.
Survival by HK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HK2 | 3099 | 9 | 2 | 19 | |
| GSE20123 | HK2 | 3099 | 9 | 2 | 19 | |
| GSE43470 | HK2 | 3099 | 4 | 0 | 39 | |
| GSE46452 | HK2 | 3099 | 2 | 3 | 54 | |
| GSE47630 | HK2 | 3099 | 7 | 0 | 33 | |
| GSE54993 | HK2 | 3099 | 0 | 6 | 64 | |
| GSE54994 | HK2 | 3099 | 10 | 0 | 43 | |
| GSE60625 | HK2 | 3099 | 0 | 3 | 8 | |
| GSE74703 | HK2 | 3099 | 4 | 0 | 32 | |
| GSE74704 | HK2 | 3099 | 8 | 0 | 12 | |
| TCGA | HK2 | 3099 | 37 | 2 | 57 |
Total number of gains: 90; Total number of losses: 18; Total Number of normals: 380.
Somatic mutations of HK2:
Generating mutation plots.
Highly correlated genes for HK2:
Showing top 20/302 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HK2 | PPP3CA | 0.729315 | 3 | 0 | 3 |
| HK2 | ADCY7 | 0.714073 | 3 | 0 | 3 |
| HK2 | TTC39C | 0.707521 | 3 | 0 | 3 |
| HK2 | EME1 | 0.691737 | 3 | 0 | 3 |
| HK2 | SERPINB9 | 0.680577 | 3 | 0 | 3 |
| HK2 | CDCP1 | 0.674657 | 7 | 0 | 6 |
| HK2 | FAM83A | 0.665963 | 6 | 0 | 5 |
| HK2 | CSNK1G1 | 0.664177 | 3 | 0 | 3 |
| HK2 | SHCBP1 | 0.649607 | 6 | 0 | 6 |
| HK2 | RREB1 | 0.649418 | 5 | 0 | 4 |
| HK2 | RHBDF2 | 0.649319 | 7 | 0 | 5 |
| HK2 | VTA1 | 0.647034 | 4 | 0 | 3 |
| HK2 | ABCG1 | 0.644844 | 3 | 0 | 3 |
| HK2 | AJUBA | 0.640952 | 4 | 0 | 3 |
| HK2 | AP1B1 | 0.640314 | 3 | 0 | 3 |
| HK2 | PLIN3 | 0.639087 | 3 | 0 | 3 |
| HK2 | SPRED1 | 0.638942 | 3 | 0 | 3 |
| HK2 | SLC2A1 | 0.635371 | 11 | 0 | 10 |
| HK2 | ANLN | 0.635224 | 4 | 0 | 3 |
| HK2 | SPHK1 | 0.634019 | 8 | 0 | 7 |
For details and further investigation, click here
