| Full name: parathyroid hormone 1 receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 5745 | HGNC ID: HGNC:9608 | Ensembl Gene: ENSG00000160801 | OMIM ID: 168468 |
| Drug and gene relationship at DGIdb | |||
PTH1R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
Expression of PTH1R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTH1R | 5745 | 205911_at | -0.4815 | 0.1525 | |
| GSE20347 | PTH1R | 5745 | 205911_at | -0.2614 | 0.0007 | |
| GSE23400 | PTH1R | 5745 | 205911_at | -0.3472 | 0.0000 | |
| GSE26886 | PTH1R | 5745 | 205911_at | -0.1779 | 0.1187 | |
| GSE29001 | PTH1R | 5745 | 205911_at | -0.3008 | 0.0087 | |
| GSE38129 | PTH1R | 5745 | 205911_at | -0.5677 | 0.0000 | |
| GSE45670 | PTH1R | 5745 | 205911_at | -0.3430 | 0.0002 | |
| GSE53622 | PTH1R | 5745 | 80528 | -1.5137 | 0.0000 | |
| GSE53624 | PTH1R | 5745 | 80528 | -1.0926 | 0.0000 | |
| GSE63941 | PTH1R | 5745 | 205911_at | -0.0892 | 0.5658 | |
| GSE77861 | PTH1R | 5745 | 205911_at | -0.1532 | 0.1818 | |
| GSE97050 | PTH1R | 5745 | A_23_P167030 | -0.8640 | 0.2516 | |
| SRP064894 | PTH1R | 5745 | RNAseq | -0.2574 | 0.5570 | |
| SRP133303 | PTH1R | 5745 | RNAseq | -0.9856 | 0.0775 | |
| SRP159526 | PTH1R | 5745 | RNAseq | -1.4536 | 0.0010 | |
| SRP219564 | PTH1R | 5745 | RNAseq | -1.3538 | 0.1421 | |
| TCGA | PTH1R | 5745 | RNAseq | -1.3260 | 0.0030 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PTH1R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTH1R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTH1R | 5745 | 0 | 18 | 12 | |
| GSE20123 | PTH1R | 5745 | 0 | 19 | 11 | |
| GSE43470 | PTH1R | 5745 | 0 | 19 | 24 | |
| GSE46452 | PTH1R | 5745 | 2 | 17 | 40 | |
| GSE47630 | PTH1R | 5745 | 2 | 23 | 15 | |
| GSE54993 | PTH1R | 5745 | 7 | 2 | 61 | |
| GSE54994 | PTH1R | 5745 | 0 | 36 | 17 | |
| GSE60625 | PTH1R | 5745 | 5 | 0 | 6 | |
| GSE74703 | PTH1R | 5745 | 0 | 15 | 21 | |
| GSE74704 | PTH1R | 5745 | 0 | 12 | 8 | |
| TCGA | PTH1R | 5745 | 1 | 75 | 20 |
Total number of gains: 17; Total number of losses: 236; Total Number of normals: 235.
Somatic mutations of PTH1R:
Generating mutation plots.
Highly correlated genes for PTH1R:
Showing top 20/1200 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTH1R | SORCS1 | 0.818059 | 4 | 0 | 4 |
| PTH1R | SPRYD3 | 0.787977 | 3 | 0 | 3 |
| PTH1R | CYP21A2 | 0.786594 | 3 | 0 | 3 |
| PTH1R | NEGR1 | 0.780521 | 5 | 0 | 5 |
| PTH1R | KLHL30 | 0.777236 | 3 | 0 | 3 |
| PTH1R | CYS1 | 0.767056 | 4 | 0 | 4 |
| PTH1R | CLEC3B | 0.756765 | 3 | 0 | 3 |
| PTH1R | TNFSF12 | 0.749242 | 3 | 0 | 3 |
| PTH1R | EBF1 | 0.74902 | 4 | 0 | 4 |
| PTH1R | RBFOX3 | 0.747196 | 3 | 0 | 3 |
| PTH1R | ADRB3 | 0.747 | 3 | 0 | 3 |
| PTH1R | FXYD1 | 0.746479 | 7 | 0 | 7 |
| PTH1R | RANBP3L | 0.737928 | 4 | 0 | 4 |
| PTH1R | HPSE2 | 0.732173 | 9 | 0 | 9 |
| PTH1R | ADAMTSL1 | 0.727179 | 5 | 0 | 5 |
| PTH1R | CASQ2 | 0.723974 | 9 | 0 | 9 |
| PTH1R | CYP2U1 | 0.723929 | 4 | 0 | 4 |
| PTH1R | CCL14 | 0.7229 | 3 | 0 | 3 |
| PTH1R | XKR4 | 0.721869 | 5 | 0 | 4 |
| PTH1R | F10 | 0.716711 | 10 | 0 | 9 |
For details and further investigation, click here
