| Full name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q36.1 | ||
| Entrez ID: 116988 | HGNC ID: HGNC:16923 | Ensembl Gene: ENSG00000133612 | OMIM ID: 616813 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AGAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGAP3 | 116988 | 225789_at | 0.1446 | 0.8044 | |
| GSE26886 | AGAP3 | 116988 | 225789_at | -0.0322 | 0.9244 | |
| GSE45670 | AGAP3 | 116988 | 225789_at | 0.0743 | 0.5044 | |
| GSE53622 | AGAP3 | 116988 | 73511 | -0.3415 | 0.0000 | |
| GSE53624 | AGAP3 | 116988 | 73511 | -0.0673 | 0.2282 | |
| GSE63941 | AGAP3 | 116988 | 225789_at | -0.2102 | 0.4358 | |
| GSE77861 | AGAP3 | 116988 | 239026_x_at | -0.2771 | 0.0903 | |
| GSE97050 | AGAP3 | 116988 | A_33_P3240543 | -0.0830 | 0.7823 | |
| SRP007169 | AGAP3 | 116988 | RNAseq | -0.4877 | 0.1857 | |
| SRP008496 | AGAP3 | 116988 | RNAseq | -0.4772 | 0.0714 | |
| SRP064894 | AGAP3 | 116988 | RNAseq | 0.2523 | 0.1950 | |
| SRP133303 | AGAP3 | 116988 | RNAseq | -0.2789 | 0.0579 | |
| SRP159526 | AGAP3 | 116988 | RNAseq | -0.1046 | 0.6997 | |
| SRP193095 | AGAP3 | 116988 | RNAseq | -0.0840 | 0.5002 | |
| SRP219564 | AGAP3 | 116988 | RNAseq | -0.0013 | 0.9960 | |
| TCGA | AGAP3 | 116988 | RNAseq | 0.0485 | 0.3838 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AGAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGAP3 | 116988 | 2 | 4 | 24 | |
| GSE20123 | AGAP3 | 116988 | 2 | 4 | 24 | |
| GSE43470 | AGAP3 | 116988 | 2 | 5 | 36 | |
| GSE46452 | AGAP3 | 116988 | 7 | 2 | 50 | |
| GSE47630 | AGAP3 | 116988 | 5 | 9 | 26 | |
| GSE54993 | AGAP3 | 116988 | 3 | 3 | 64 | |
| GSE54994 | AGAP3 | 116988 | 5 | 8 | 40 | |
| GSE60625 | AGAP3 | 116988 | 0 | 0 | 11 | |
| GSE74703 | AGAP3 | 116988 | 2 | 4 | 30 | |
| GSE74704 | AGAP3 | 116988 | 1 | 4 | 15 | |
| TCGA | AGAP3 | 116988 | 28 | 25 | 43 |
Total number of gains: 57; Total number of losses: 68; Total Number of normals: 363.
Somatic mutations of AGAP3:
Generating mutation plots.
Highly correlated genes for AGAP3:
Showing top 20/48 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGAP3 | HEPACAM2 | 0.7434 | 3 | 0 | 3 |
| AGAP3 | LYPLA2 | 0.728019 | 3 | 0 | 3 |
| AGAP3 | HES2 | 0.705026 | 3 | 0 | 3 |
| AGAP3 | NHP2 | 0.677891 | 3 | 0 | 3 |
| AGAP3 | MRPL23 | 0.666915 | 4 | 0 | 3 |
| AGAP3 | ZNF786 | 0.638505 | 4 | 0 | 3 |
| AGAP3 | DNAJB12 | 0.636624 | 3 | 0 | 3 |
| AGAP3 | SAMD10 | 0.631513 | 3 | 0 | 3 |
| AGAP3 | NCLN | 0.620094 | 3 | 0 | 3 |
| AGAP3 | HSPB1 | 0.616374 | 3 | 0 | 3 |
| AGAP3 | AKR7A3 | 0.612135 | 3 | 0 | 3 |
| AGAP3 | PAOX | 0.611669 | 4 | 0 | 4 |
| AGAP3 | ACTL8 | 0.609466 | 3 | 0 | 3 |
| AGAP3 | KIF1C | 0.608656 | 3 | 0 | 3 |
| AGAP3 | ADAM15 | 0.602566 | 3 | 0 | 3 |
| AGAP3 | NDUFB2-AS1 | 0.599356 | 4 | 0 | 3 |
| AGAP3 | TMEM120A | 0.597842 | 3 | 0 | 3 |
| AGAP3 | ZBTB42 | 0.594302 | 4 | 0 | 3 |
| AGAP3 | HRAS | 0.592897 | 4 | 0 | 3 |
| AGAP3 | TSSC4 | 0.590812 | 3 | 0 | 3 |
For details and further investigation, click here
