| Full name: mitochondrial ribosomal protein L23 | Alias Symbol: L23MRP | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 6150 | HGNC ID: HGNC:10322 | Ensembl Gene: ENSG00000214026 | OMIM ID: 600789 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL23 | 6150 | 213897_s_at | -0.1250 | 0.7591 | |
| GSE20347 | MRPL23 | 6150 | 213897_s_at | -0.5603 | 0.0005 | |
| GSE23400 | MRPL23 | 6150 | 213897_s_at | 0.0409 | 0.6998 | |
| GSE26886 | MRPL23 | 6150 | 213897_s_at | 0.4886 | 0.0402 | |
| GSE29001 | MRPL23 | 6150 | 213897_s_at | -0.5095 | 0.2912 | |
| GSE38129 | MRPL23 | 6150 | 213897_s_at | -0.2508 | 0.0982 | |
| GSE45670 | MRPL23 | 6150 | 213897_s_at | -0.1077 | 0.4775 | |
| GSE53622 | MRPL23 | 6150 | 91794 | -0.4565 | 0.0000 | |
| GSE53624 | MRPL23 | 6150 | 91794 | -0.3334 | 0.0000 | |
| GSE63941 | MRPL23 | 6150 | 213897_s_at | 0.1473 | 0.8125 | |
| GSE77861 | MRPL23 | 6150 | 213897_s_at | -0.3197 | 0.5066 | |
| GSE97050 | MRPL23 | 6150 | A_23_P105044 | -0.1136 | 0.7057 | |
| SRP007169 | MRPL23 | 6150 | RNAseq | -1.0009 | 0.0087 | |
| SRP008496 | MRPL23 | 6150 | RNAseq | -0.6619 | 0.0070 | |
| SRP064894 | MRPL23 | 6150 | RNAseq | 0.2259 | 0.5851 | |
| SRP133303 | MRPL23 | 6150 | RNAseq | -0.2589 | 0.1518 | |
| SRP159526 | MRPL23 | 6150 | RNAseq | -0.4866 | 0.0107 | |
| SRP193095 | MRPL23 | 6150 | RNAseq | -0.6574 | 0.0000 | |
| SRP219564 | MRPL23 | 6150 | RNAseq | 0.2343 | 0.5676 | |
| TCGA | MRPL23 | 6150 | RNAseq | 0.0070 | 0.9217 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MRPL23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL23 | 6150 | 1 | 11 | 18 | |
| GSE20123 | MRPL23 | 6150 | 1 | 12 | 17 | |
| GSE43470 | MRPL23 | 6150 | 1 | 9 | 33 | |
| GSE46452 | MRPL23 | 6150 | 7 | 8 | 44 | |
| GSE47630 | MRPL23 | 6150 | 4 | 12 | 24 | |
| GSE54993 | MRPL23 | 6150 | 3 | 1 | 66 | |
| GSE54994 | MRPL23 | 6150 | 1 | 12 | 40 | |
| GSE60625 | MRPL23 | 6150 | 0 | 0 | 11 | |
| GSE74703 | MRPL23 | 6150 | 1 | 7 | 28 | |
| GSE74704 | MRPL23 | 6150 | 0 | 8 | 12 | |
| TCGA | MRPL23 | 6150 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 119; Total Number of normals: 342.
Somatic mutations of MRPL23:
Generating mutation plots.
Highly correlated genes for MRPL23:
Showing top 20/257 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL23 | EAPP | 0.695639 | 4 | 0 | 3 |
| MRPL23 | DYNLL1 | 0.684114 | 5 | 0 | 5 |
| MRPL23 | SAMD10 | 0.679813 | 3 | 0 | 3 |
| MRPL23 | AGAP3 | 0.666915 | 4 | 0 | 3 |
| MRPL23 | RETSAT | 0.658429 | 4 | 0 | 3 |
| MRPL23 | MCM9 | 0.655183 | 3 | 0 | 3 |
| MRPL23 | ARCN1 | 0.650943 | 3 | 0 | 3 |
| MRPL23 | PNPLA4 | 0.638634 | 5 | 0 | 4 |
| MRPL23 | WDR47 | 0.628714 | 4 | 0 | 3 |
| MRPL23 | HRAS | 0.627367 | 11 | 0 | 8 |
| MRPL23 | ENDOG | 0.627019 | 5 | 0 | 3 |
| MRPL23 | RPL29 | 0.622624 | 8 | 0 | 5 |
| MRPL23 | TOLLIP | 0.619799 | 7 | 0 | 6 |
| MRPL23 | MUC20 | 0.617463 | 3 | 0 | 3 |
| MRPL23 | MYL12B | 0.61741 | 3 | 0 | 3 |
| MRPL23 | ANKRD31 | 0.615608 | 3 | 0 | 3 |
| MRPL23 | CELSR2 | 0.610637 | 4 | 0 | 4 |
| MRPL23 | RPUSD1 | 0.610178 | 3 | 0 | 3 |
| MRPL23 | CYB5R2 | 0.608522 | 4 | 0 | 4 |
| MRPL23 | TAF10 | 0.606421 | 13 | 0 | 8 |
For details and further investigation, click here
