HRAS

 

Full name: HRas proto-oncogene, GTPase Alias Symbol: 
Type: protein-coding gene Cytoband: 11p15.5
Entrez ID: 3265 HGNC ID: HGNC:5173 Ensembl Gene: ENSG00000174775 OMIM ID: 190020
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

HRAS involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04062Chemokine signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04540Gap junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05034Alcoholism
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of HRAS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HRAS 3265 212983_at 0.0425 0.9471
GSE20347 HRAS 3265 212983_at -0.4223 0.0068
GSE23400 HRAS 3265 212983_at -0.0743 0.5371
GSE26886 HRAS 3265 212983_at -0.3943 0.0381
GSE29001 HRAS 3265 212983_at -0.3463 0.3440
GSE38129 HRAS 3265 212983_at -0.1055 0.5212
GSE45670 HRAS 3265 212983_at 0.3061 0.0660
GSE53622 HRAS 3265 8197 -0.1132 0.2434
GSE53624 HRAS 3265 8197 -0.1014 0.1404
GSE63941 HRAS 3265 212983_at 0.2505 0.5941
GSE77861 HRAS 3265 212983_at 0.0234 0.9475
GSE97050 HRAS 3265 A_23_P98183 -0.0847 0.7555
SRP007169 HRAS 3265 RNAseq -0.6947 0.0310
SRP008496 HRAS 3265 RNAseq -0.4685 0.0307
SRP064894 HRAS 3265 RNAseq 0.5284 0.1222
SRP133303 HRAS 3265 RNAseq 0.0003 0.9985
SRP159526 HRAS 3265 RNAseq -0.3235 0.3511
SRP193095 HRAS 3265 RNAseq -0.2204 0.2731
SRP219564 HRAS 3265 RNAseq 0.0005 0.9991
TCGA HRAS 3265 RNAseq 0.3336 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by HRAS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HRAS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HRAS 3265 1 11 18
GSE20123 HRAS 3265 1 12 17
GSE43470 HRAS 3265 1 10 32
GSE46452 HRAS 3265 7 8 44
GSE47630 HRAS 3265 4 12 24
GSE54993 HRAS 3265 3 2 65
GSE54994 HRAS 3265 1 12 40
GSE60625 HRAS 3265 0 0 11
GSE74703 HRAS 3265 1 8 27
GSE74704 HRAS 3265 0 8 12
TCGA HRAS 3265 8 38 50

Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.  

 

Somatic mutations of HRAS:

 

Generating mutation plots.

 

Highly correlated genes for HRAS:

 

Showing top 20/198 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HRASNHSL10.663418303
HRASFDXR0.634117404
HRASPGLYRP30.634106303
HRASMRPL230.6273671108
HRASRUSC10.622013604
HRASRNF60.617255505
HRASZDHHC120.605664605
HRASPKP30.6032881108
HRASTALDO10.602254705
HRASAGAP30.592897403
HRASKRT50.5906971008
HRASZNF385A0.589433303
HRASFAM83G0.589224604
HRASHM130.5875505
HRASDGKA0.5819381006
HRASLAD10.5817131109
HRASRNH10.580951907
HRASGSTP10.577312908
HRASPGAP20.576324806
HRASESPN0.576044503

For details and further investigation, click here