| Full name: protein tyrosine phosphatase non-receptor type 18 | Alias Symbol: BDP1 | ||
| Type: protein-coding gene | Cytoband: 2q21.1 | ||
| Entrez ID: 26469 | HGNC ID: HGNC:9649 | Ensembl Gene: ENSG00000072135 | OMIM ID: 606587 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPN18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN18 | 26469 | 213521_at | -0.0355 | 0.9559 | |
| GSE20347 | PTPN18 | 26469 | 203555_at | -0.0661 | 0.5395 | |
| GSE23400 | PTPN18 | 26469 | 213521_at | 0.1424 | 0.0115 | |
| GSE26886 | PTPN18 | 26469 | 213521_at | -0.1996 | 0.2412 | |
| GSE29001 | PTPN18 | 26469 | 213521_at | 0.0639 | 0.8275 | |
| GSE38129 | PTPN18 | 26469 | 203555_at | -0.1507 | 0.0864 | |
| GSE45670 | PTPN18 | 26469 | 213521_at | -0.0718 | 0.5686 | |
| GSE53622 | PTPN18 | 26469 | 81314 | -0.0065 | 0.9385 | |
| GSE53624 | PTPN18 | 26469 | 81314 | -0.0171 | 0.8017 | |
| GSE63941 | PTPN18 | 26469 | 203555_at | 1.3398 | 0.0081 | |
| GSE77861 | PTPN18 | 26469 | 203555_at | -0.0086 | 0.9712 | |
| GSE97050 | PTPN18 | 26469 | A_23_P210015 | 0.3043 | 0.2539 | |
| SRP007169 | PTPN18 | 26469 | RNAseq | 0.1022 | 0.7914 | |
| SRP008496 | PTPN18 | 26469 | RNAseq | 0.0525 | 0.8450 | |
| SRP064894 | PTPN18 | 26469 | RNAseq | 0.3928 | 0.0844 | |
| SRP133303 | PTPN18 | 26469 | RNAseq | -0.4004 | 0.0004 | |
| SRP159526 | PTPN18 | 26469 | RNAseq | -0.1988 | 0.4880 | |
| SRP193095 | PTPN18 | 26469 | RNAseq | -0.2916 | 0.0914 | |
| SRP219564 | PTPN18 | 26469 | RNAseq | 0.2314 | 0.4664 | |
| TCGA | PTPN18 | 26469 | RNAseq | -0.2323 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PTPN18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN18 | 26469 | 5 | 3 | 22 | |
| GSE20123 | PTPN18 | 26469 | 5 | 3 | 22 | |
| GSE43470 | PTPN18 | 26469 | 2 | 2 | 39 | |
| GSE46452 | PTPN18 | 26469 | 1 | 3 | 55 | |
| GSE47630 | PTPN18 | 26469 | 5 | 0 | 35 | |
| GSE54993 | PTPN18 | 26469 | 0 | 6 | 64 | |
| GSE54994 | PTPN18 | 26469 | 11 | 0 | 42 | |
| GSE60625 | PTPN18 | 26469 | 0 | 3 | 8 | |
| GSE74703 | PTPN18 | 26469 | 2 | 1 | 33 | |
| GSE74704 | PTPN18 | 26469 | 3 | 1 | 16 | |
| TCGA | PTPN18 | 26469 | 22 | 9 | 65 |
Total number of gains: 56; Total number of losses: 31; Total Number of normals: 401.
Somatic mutations of PTPN18:
Generating mutation plots.
Highly correlated genes for PTPN18:
Showing top 20/69 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN18 | AGPAT1 | 0.710326 | 3 | 0 | 3 |
| PTPN18 | SIRT3 | 0.662048 | 5 | 0 | 4 |
| PTPN18 | SNX32 | 0.657214 | 3 | 0 | 3 |
| PTPN18 | WDR34 | 0.655827 | 3 | 0 | 3 |
| PTPN18 | OTUD5 | 0.652751 | 3 | 0 | 3 |
| PTPN18 | LRTOMT | 0.648799 | 3 | 0 | 3 |
| PTPN18 | ST14 | 0.635914 | 3 | 0 | 3 |
| PTPN18 | RBM14 | 0.629372 | 3 | 0 | 3 |
| PTPN18 | RAD9A | 0.620519 | 3 | 0 | 3 |
| PTPN18 | ZNF384 | 0.619064 | 4 | 0 | 3 |
| PTPN18 | RPARP-AS1 | 0.618712 | 3 | 0 | 3 |
| PTPN18 | ATP2A3 | 0.617179 | 5 | 0 | 4 |
| PTPN18 | C15orf39 | 0.615918 | 5 | 0 | 4 |
| PTPN18 | CCDC151 | 0.612369 | 4 | 0 | 3 |
| PTPN18 | B3GNTL1 | 0.602696 | 4 | 0 | 3 |
| PTPN18 | SMPDL3B | 0.602412 | 4 | 0 | 3 |
| PTPN18 | FIZ1 | 0.59857 | 4 | 0 | 4 |
| PTPN18 | OR7E24 | 0.597434 | 3 | 0 | 3 |
| PTPN18 | ELK1 | 0.597404 | 4 | 0 | 3 |
| PTPN18 | ARHGEF16 | 0.586285 | 4 | 0 | 3 |
For details and further investigation, click here
