| Full name: polo like kinase 5 | Alias Symbol: SgK384ps | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 126520 | HGNC ID: HGNC:27001 | Ensembl Gene: ENSG00000185988 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PLK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLK5 | 126520 | 1558897_at | -0.2348 | 0.3287 | |
| GSE26886 | PLK5 | 126520 | 1558897_at | 0.0494 | 0.6575 | |
| GSE45670 | PLK5 | 126520 | 1558897_at | -0.0844 | 0.2862 | |
| GSE53622 | PLK5 | 126520 | 152946 | -0.4166 | 0.0041 | |
| GSE53624 | PLK5 | 126520 | 152946 | -1.4055 | 0.0000 | |
| GSE63941 | PLK5 | 126520 | 1558897_at | 0.2395 | 0.1283 | |
| GSE77861 | PLK5 | 126520 | 1558897_at | -0.1446 | 0.2970 | |
| SRP064894 | PLK5 | 126520 | RNAseq | -1.0629 | 0.0000 | |
| SRP133303 | PLK5 | 126520 | RNAseq | -0.2332 | 0.2137 | |
| SRP159526 | PLK5 | 126520 | RNAseq | -0.4113 | 0.4634 | |
| SRP193095 | PLK5 | 126520 | RNAseq | -0.2064 | 0.1778 | |
| SRP219564 | PLK5 | 126520 | RNAseq | -0.8698 | 0.0133 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PLK5 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of PLK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLK5 | 126520 | 4 | 6 | 20 | |
| GSE20123 | PLK5 | 126520 | 4 | 5 | 21 | |
| GSE43470 | PLK5 | 126520 | 1 | 11 | 31 | |
| GSE46452 | PLK5 | 126520 | 47 | 1 | 11 | |
| GSE47630 | PLK5 | 126520 | 5 | 7 | 28 | |
| GSE54993 | PLK5 | 126520 | 16 | 3 | 51 | |
| GSE54994 | PLK5 | 126520 | 8 | 15 | 30 | |
| GSE60625 | PLK5 | 126520 | 9 | 0 | 2 | |
| GSE74703 | PLK5 | 126520 | 1 | 8 | 27 | |
| GSE74704 | PLK5 | 126520 | 3 | 3 | 14 | |
| TCGA | PLK5 | 126520 | 6 | 25 | 65 |
Total number of gains: 104; Total number of losses: 84; Total Number of normals: 300.
Somatic mutations of PLK5:
Generating mutation plots.
Highly correlated genes for PLK5:
Showing top 20/90 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLK5 | PAX3 | 0.746715 | 3 | 0 | 3 |
| PLK5 | AGXT | 0.696102 | 3 | 0 | 3 |
| PLK5 | CIB4 | 0.689751 | 3 | 0 | 3 |
| PLK5 | SPATA3 | 0.665024 | 3 | 0 | 3 |
| PLK5 | INSRR | 0.66379 | 3 | 0 | 3 |
| PLK5 | EPHA10 | 0.661063 | 3 | 0 | 3 |
| PLK5 | KCNQ1DN | 0.653237 | 3 | 0 | 3 |
| PLK5 | AVPR2 | 0.650355 | 3 | 0 | 3 |
| PLK5 | ARHGDIG | 0.649264 | 4 | 0 | 3 |
| PLK5 | TMPRSS6 | 0.63895 | 3 | 0 | 3 |
| PLK5 | AMZ1 | 0.637141 | 3 | 0 | 3 |
| PLK5 | CSNK1G2-AS1 | 0.629698 | 3 | 0 | 3 |
| PLK5 | PTH2 | 0.626356 | 3 | 0 | 3 |
| PLK5 | KIF25-AS1 | 0.622301 | 4 | 0 | 3 |
| PLK5 | CRTC1 | 0.620984 | 4 | 0 | 3 |
| PLK5 | PRX | 0.612939 | 4 | 0 | 3 |
| PLK5 | PAX4 | 0.609698 | 3 | 0 | 3 |
| PLK5 | GJB1 | 0.609581 | 3 | 0 | 3 |
| PLK5 | SCN2B | 0.608312 | 4 | 0 | 3 |
| PLK5 | EVPLL | 0.607143 | 3 | 0 | 3 |
For details and further investigation, click here
