| Full name: adenosylhomocysteinase like 2 | Alias Symbol: KIAA0828|long-IRBIT|IRBIT2 | ||
| Type: protein-coding gene | Cytoband: 7q32.1 | ||
| Entrez ID: 23382 | HGNC ID: HGNC:22204 | Ensembl Gene: ENSG00000158467 | OMIM ID: 616520 |
| Drug and gene relationship at DGIdb | |||
Expression of AHCYL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AHCYL2 | 23382 | 212814_at | 0.0206 | 0.9750 | |
| GSE20347 | AHCYL2 | 23382 | 212814_at | -0.3507 | 0.0095 | |
| GSE23400 | AHCYL2 | 23382 | 215672_s_at | -0.1547 | 0.0000 | |
| GSE26886 | AHCYL2 | 23382 | 212814_at | -1.1104 | 0.0001 | |
| GSE29001 | AHCYL2 | 23382 | 212814_at | 0.1498 | 0.7176 | |
| GSE38129 | AHCYL2 | 23382 | 212814_at | -0.3609 | 0.0009 | |
| GSE45670 | AHCYL2 | 23382 | 212814_at | -0.3069 | 0.1963 | |
| GSE53622 | AHCYL2 | 23382 | 55041 | -0.7511 | 0.0000 | |
| GSE53624 | AHCYL2 | 23382 | 55041 | -0.8545 | 0.0000 | |
| GSE63941 | AHCYL2 | 23382 | 212814_at | 0.2016 | 0.5811 | |
| GSE77861 | AHCYL2 | 23382 | 212814_at | -0.3753 | 0.0640 | |
| GSE97050 | AHCYL2 | 23382 | A_24_P72518 | -0.1304 | 0.7088 | |
| SRP007169 | AHCYL2 | 23382 | RNAseq | -0.7768 | 0.0507 | |
| SRP008496 | AHCYL2 | 23382 | RNAseq | -0.2331 | 0.4760 | |
| SRP064894 | AHCYL2 | 23382 | RNAseq | -0.3865 | 0.1231 | |
| SRP133303 | AHCYL2 | 23382 | RNAseq | -0.5658 | 0.0023 | |
| SRP159526 | AHCYL2 | 23382 | RNAseq | -0.6945 | 0.0234 | |
| SRP193095 | AHCYL2 | 23382 | RNAseq | -1.2093 | 0.0000 | |
| SRP219564 | AHCYL2 | 23382 | RNAseq | -0.4432 | 0.3015 | |
| TCGA | AHCYL2 | 23382 | RNAseq | -0.6069 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by AHCYL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AHCYL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AHCYL2 | 23382 | 8 | 1 | 21 | |
| GSE20123 | AHCYL2 | 23382 | 8 | 1 | 21 | |
| GSE43470 | AHCYL2 | 23382 | 2 | 3 | 38 | |
| GSE46452 | AHCYL2 | 23382 | 7 | 2 | 50 | |
| GSE47630 | AHCYL2 | 23382 | 7 | 4 | 29 | |
| GSE54993 | AHCYL2 | 23382 | 3 | 5 | 62 | |
| GSE54994 | AHCYL2 | 23382 | 8 | 7 | 38 | |
| GSE60625 | AHCYL2 | 23382 | 0 | 0 | 11 | |
| GSE74703 | AHCYL2 | 23382 | 2 | 3 | 31 | |
| GSE74704 | AHCYL2 | 23382 | 4 | 1 | 15 | |
| TCGA | AHCYL2 | 23382 | 29 | 22 | 45 |
Total number of gains: 78; Total number of losses: 49; Total Number of normals: 361.
Somatic mutations of AHCYL2:
Generating mutation plots.
Highly correlated genes for AHCYL2:
Showing top 20/527 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AHCYL2 | C2CD2 | 0.776646 | 3 | 0 | 3 |
| AHCYL2 | DUSP18 | 0.767566 | 3 | 0 | 3 |
| AHCYL2 | ANO8 | 0.767097 | 3 | 0 | 3 |
| AHCYL2 | ZFP3 | 0.763016 | 3 | 0 | 3 |
| AHCYL2 | TMEM117 | 0.746214 | 3 | 0 | 3 |
| AHCYL2 | CCNYL1 | 0.743998 | 4 | 0 | 4 |
| AHCYL2 | CNOT4 | 0.743667 | 3 | 0 | 3 |
| AHCYL2 | ZNF70 | 0.739213 | 3 | 0 | 3 |
| AHCYL2 | VPS26B | 0.734901 | 3 | 0 | 3 |
| AHCYL2 | CYB5R1 | 0.721104 | 3 | 0 | 3 |
| AHCYL2 | ZNF547 | 0.718443 | 3 | 0 | 3 |
| AHCYL2 | ZNF607 | 0.715655 | 3 | 0 | 3 |
| AHCYL2 | SIKE1 | 0.709295 | 4 | 0 | 4 |
| AHCYL2 | TBC1D20 | 0.707694 | 3 | 0 | 3 |
| AHCYL2 | PPP1R3D | 0.706127 | 4 | 0 | 3 |
| AHCYL2 | PALB2 | 0.701501 | 3 | 0 | 3 |
| AHCYL2 | LTN1 | 0.699329 | 3 | 0 | 3 |
| AHCYL2 | COPG2 | 0.694357 | 5 | 0 | 4 |
| AHCYL2 | RWDD2B | 0.693222 | 4 | 0 | 3 |
| AHCYL2 | KCTD21 | 0.691213 | 3 | 0 | 3 |
For details and further investigation, click here
