C1QB

 

Full name: complement C1q B chain Alias Symbol: 
Type: protein-coding gene Cytoband: 1p36.12
Entrez ID: 713 HGNC ID: HGNC:1242 Ensembl Gene: ENSG00000173369 OMIM ID: 120570
Drug and gene relationship at DGIdb

 

C1QB involved pathways:

KEGG pathway Description View
hsa04610Complement and coagulation cascades
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05150Staphylococcus aureus infection

 

Expression of C1QB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C1QB 713 202953_at 0.5779 0.6280
GSE20347 C1QB 713 202953_at 0.9023 0.0074
GSE23400 C1QB 713 202953_at 0.9282 0.0000
GSE26886 C1QB 713 202953_at 1.2755 0.0092
GSE29001 C1QB 713 202953_at 1.5293 0.0022
GSE38129 C1QB 713 202953_at 0.9527 0.0082
GSE45670 C1QB 713 202953_at -0.0107 0.9857
GSE53622 C1QB 713 88350 0.8000 0.0000
GSE53624 C1QB 713 88350 1.1986 0.0000
GSE63941 C1QB 713 202953_at 0.0553 0.7324
GSE77861 C1QB 713 202953_at 0.6095 0.0960
GSE97050 C1QB 713 A_23_P137366 0.6432 0.3252
SRP007169 C1QB 713 RNAseq 2.1386 0.0042
SRP008496 C1QB 713 RNAseq 1.7595 0.0003
SRP064894 C1QB 713 RNAseq 1.7310 0.0004
SRP133303 C1QB 713 RNAseq 1.1219 0.0083
SRP159526 C1QB 713 RNAseq 0.8328 0.2249
SRP193095 C1QB 713 RNAseq 0.9129 0.0023
SRP219564 C1QB 713 RNAseq 2.0830 0.0166
TCGA C1QB 713 RNAseq 0.3648 0.0037

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by C1QB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of C1QB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C1QB 713 0 5 25
GSE20123 C1QB 713 0 4 26
GSE43470 C1QB 713 2 6 35
GSE46452 C1QB 713 5 1 53
GSE47630 C1QB 713 8 3 29
GSE54993 C1QB 713 2 1 67
GSE54994 C1QB 713 11 4 38
GSE60625 C1QB 713 0 0 11
GSE74703 C1QB 713 1 4 31
GSE74704 C1QB 713 0 0 20
TCGA C1QB 713 10 23 63

Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.  

 

Somatic mutations of C1QB:

 

Generating mutation plots.

 

Highly correlated genes for C1QB:

 

Showing top 20/1103 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C1QBC1QA0.90868312012
C1QBTYROBP0.89522812012
C1QBFCER1G0.88397111011
C1QBC1QC0.870103808
C1QBCD140.84427112012
C1QBC3AR10.80072411010
C1QBTFEC0.78300410010
C1QBMS4A4A0.77363911011
C1QBRASSF40.766025606
C1QBCD1630.76272613012
C1QBFPR30.761672807
C1QBLAPTM50.75331812011
C1QBAIF10.74371112012
C1QBITGB20.74356911011
C1QBCYBB0.74022211011
C1QBMS4A6A0.737131009
C1QBSLC7A70.73392112011
C1QBPLXNC10.73271009
C1QBFCGR2A0.73190612012
C1QBPLA2G70.73107112012

For details and further investigation, click here