PIK3CG

 

Full name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Alias Symbol: 
Type: protein-coding gene Cytoband: 7q22.3
Entrez ID: 5294 HGNC ID: HGNC:8978 Ensembl Gene: ENSG00000105851 OMIM ID: 601232
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PIK3CG involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04960Aldosterone-regulated sodium reabsorption
hsa04973Carbohydrate digestion and absorption
hsa05100Bacterial invasion of epithelial cells
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PIK3CG:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PIK3CG 5294 239294_at 0.3868 0.8089
GSE20347 PIK3CG 5294 206369_s_at 0.0069 0.9186
GSE23400 PIK3CG 5294 206369_s_at -0.0470 0.2309
GSE26886 PIK3CG 5294 239294_at -0.1295 0.8084
GSE29001 PIK3CG 5294 206369_s_at -0.0038 0.9822
GSE38129 PIK3CG 5294 206370_at -0.0320 0.6749
GSE45670 PIK3CG 5294 239294_at -0.5451 0.0851
GSE53622 PIK3CG 5294 113099 0.0120 0.9409
GSE53624 PIK3CG 5294 113099 -0.2316 0.1609
GSE63941 PIK3CG 5294 206369_s_at 0.1300 0.2867
GSE77861 PIK3CG 5294 239294_at -0.0235 0.8332
GSE97050 PIK3CG 5294 A_33_P3304170 0.1298 0.8735
SRP007169 PIK3CG 5294 RNAseq 0.9685 0.1425
SRP008496 PIK3CG 5294 RNAseq 0.8974 0.0720
SRP064894 PIK3CG 5294 RNAseq 0.5502 0.0517
SRP133303 PIK3CG 5294 RNAseq -0.0223 0.9014
SRP159526 PIK3CG 5294 RNAseq -0.3154 0.7193
SRP193095 PIK3CG 5294 RNAseq -0.1418 0.5730
SRP219564 PIK3CG 5294 RNAseq 0.8673 0.0735
TCGA PIK3CG 5294 RNAseq -0.1504 0.5000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PIK3CG expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PIK3CG:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PIK3CG 5294 12 0 18
GSE20123 PIK3CG 5294 12 0 18
GSE43470 PIK3CG 5294 6 2 35
GSE46452 PIK3CG 5294 10 1 48
GSE47630 PIK3CG 5294 7 3 30
GSE54993 PIK3CG 5294 2 9 59
GSE54994 PIK3CG 5294 16 3 34
GSE60625 PIK3CG 5294 0 0 11
GSE74703 PIK3CG 5294 6 2 28
GSE74704 PIK3CG 5294 8 0 12
TCGA PIK3CG 5294 51 10 35

Total number of gains: 130; Total number of losses: 30; Total Number of normals: 328.  

 

Somatic mutations of PIK3CG:

 

Generating mutation plots.

 

Highly correlated genes for PIK3CG:

 

Showing top 20/321 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PIK3CGC16orf540.834191505
PIK3CGCD1D0.786169404
PIK3CGIL10RA0.785376706
PIK3CGNCKAP1L0.782256707
PIK3CGSLAMF60.781767404
PIK3CGSNX200.7805504
PIK3CGGNGT20.760482303
PIK3CGARHGAP90.757638605
PIK3CGIRF80.750714707
PIK3CGIFNA70.750691303
PIK3CGCD530.746342505
PIK3CGITK0.741062808
PIK3CGPARVG0.740559505
PIK3CGCD480.73726807
PIK3CGPPP1R16B0.73673404
PIK3CGMPEG10.7352504
PIK3CGGIMAP20.731831605
PIK3CGGMFG0.730497706
PIK3CGGIMAP60.723687706
PIK3CGARHGDIB0.722534706

For details and further investigation, click here