| Full name: absent in melanoma 2 | Alias Symbol: PYHIN4 | ||
| Type: protein-coding gene | Cytoband: 1q23.1-q23.2 | ||
| Entrez ID: 9447 | HGNC ID: HGNC:357 | Ensembl Gene: ENSG00000163568 | OMIM ID: 604578 |
| Drug and gene relationship at DGIdb | |||
Expression of AIM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AIM2 | 9447 | 206513_at | 1.4777 | 0.2251 | |
| GSE20347 | AIM2 | 9447 | 206513_at | 1.1680 | 0.0212 | |
| GSE23400 | AIM2 | 9447 | 206513_at | 0.5704 | 0.0000 | |
| GSE26886 | AIM2 | 9447 | 206513_at | 0.5372 | 0.3628 | |
| GSE29001 | AIM2 | 9447 | 206513_at | 2.6186 | 0.0009 | |
| GSE38129 | AIM2 | 9447 | 206513_at | 1.0208 | 0.0057 | |
| GSE45670 | AIM2 | 9447 | 206513_at | 2.3528 | 0.0001 | |
| GSE53622 | AIM2 | 9447 | 30861 | 1.4649 | 0.0000 | |
| GSE53624 | AIM2 | 9447 | 30861 | 1.8140 | 0.0000 | |
| GSE63941 | AIM2 | 9447 | 206513_at | 1.1497 | 0.4453 | |
| GSE77861 | AIM2 | 9447 | 206513_at | 0.6260 | 0.2945 | |
| GSE97050 | AIM2 | 9447 | A_32_P44394 | 1.9383 | 0.1711 | |
| SRP007169 | AIM2 | 9447 | RNAseq | 1.2235 | 0.2270 | |
| SRP064894 | AIM2 | 9447 | RNAseq | 3.2481 | 0.0000 | |
| SRP133303 | AIM2 | 9447 | RNAseq | 1.8453 | 0.0009 | |
| SRP159526 | AIM2 | 9447 | RNAseq | 0.4700 | 0.7756 | |
| SRP193095 | AIM2 | 9447 | RNAseq | 2.6523 | 0.0000 | |
| TCGA | AIM2 | 9447 | RNAseq | 1.4265 | 0.0001 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by AIM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AIM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AIM2 | 9447 | 9 | 0 | 21 | |
| GSE20123 | AIM2 | 9447 | 9 | 0 | 21 | |
| GSE43470 | AIM2 | 9447 | 7 | 2 | 34 | |
| GSE46452 | AIM2 | 9447 | 2 | 1 | 56 | |
| GSE47630 | AIM2 | 9447 | 14 | 0 | 26 | |
| GSE54993 | AIM2 | 9447 | 0 | 5 | 65 | |
| GSE54994 | AIM2 | 9447 | 16 | 0 | 37 | |
| GSE60625 | AIM2 | 9447 | 0 | 0 | 11 | |
| GSE74703 | AIM2 | 9447 | 7 | 2 | 27 | |
| GSE74704 | AIM2 | 9447 | 3 | 0 | 17 | |
| TCGA | AIM2 | 9447 | 42 | 4 | 50 |
Total number of gains: 109; Total number of losses: 14; Total Number of normals: 365.
Somatic mutations of AIM2:
Generating mutation plots.
Highly correlated genes for AIM2:
Showing top 20/595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AIM2 | RBM12B | 0.783408 | 3 | 0 | 3 |
| AIM2 | HELZ2 | 0.744603 | 4 | 0 | 4 |
| AIM2 | TAP1 | 0.718014 | 11 | 0 | 10 |
| AIM2 | C6orf62 | 0.710102 | 3 | 0 | 3 |
| AIM2 | MICALCL | 0.709781 | 3 | 0 | 3 |
| AIM2 | OCIAD2 | 0.704492 | 4 | 0 | 3 |
| AIM2 | USP41 | 0.702934 | 3 | 0 | 3 |
| AIM2 | GBP1 | 0.693825 | 12 | 0 | 10 |
| AIM2 | PARP14 | 0.691444 | 9 | 0 | 8 |
| AIM2 | RNF213 | 0.691195 | 4 | 0 | 3 |
| AIM2 | CXCL9 | 0.688732 | 11 | 0 | 11 |
| AIM2 | RNF166 | 0.688442 | 3 | 0 | 3 |
| AIM2 | CXCL10 | 0.687997 | 13 | 0 | 12 |
| AIM2 | LRIF1 | 0.686669 | 3 | 0 | 3 |
| AIM2 | NMI | 0.677822 | 10 | 0 | 10 |
| AIM2 | PARVG | 0.671626 | 3 | 0 | 3 |
| AIM2 | CCDC14 | 0.66523 | 3 | 0 | 3 |
| AIM2 | DTX3L | 0.660112 | 8 | 0 | 7 |
| AIM2 | DDX60 | 0.658566 | 12 | 0 | 11 |
| AIM2 | UBE2L6 | 0.657124 | 13 | 0 | 11 |
For details and further investigation, click here
