UBE2L6

 

Full name: ubiquitin conjugating enzyme E2 L6 Alias Symbol: UBCH8
Type: protein-coding gene Cytoband: 11q12.1
Entrez ID: 9246 HGNC ID: HGNC:12490 Ensembl Gene: ENSG00000156587 OMIM ID: 603890
Drug and gene relationship at DGIdb

 

Expression of UBE2L6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UBE2L6 9246 201649_at 0.7166 0.2830
GSE20347 UBE2L6 9246 201649_at 0.8154 0.0017
GSE23400 UBE2L6 9246 201649_at 0.9219 0.0000
GSE26886 UBE2L6 9246 201649_at 0.5427 0.2135
GSE29001 UBE2L6 9246 201649_at 1.2761 0.0001
GSE38129 UBE2L6 9246 201649_at 0.7152 0.0001
GSE45670 UBE2L6 9246 201649_at 1.2450 0.0002
GSE53622 UBE2L6 9246 112248 0.9623 0.0000
GSE53624 UBE2L6 9246 112248 0.9721 0.0000
GSE63941 UBE2L6 9246 201649_at 0.3882 0.7624
GSE77861 UBE2L6 9246 201649_at 0.5180 0.0244
GSE97050 UBE2L6 9246 A_23_P75741 0.6478 0.2533
SRP007169 UBE2L6 9246 RNAseq 1.2847 0.0097
SRP008496 UBE2L6 9246 RNAseq 0.8771 0.0338
SRP064894 UBE2L6 9246 RNAseq 1.2472 0.0000
SRP133303 UBE2L6 9246 RNAseq 1.2211 0.0002
SRP159526 UBE2L6 9246 RNAseq 0.6233 0.1814
SRP193095 UBE2L6 9246 RNAseq 1.2311 0.0000
SRP219564 UBE2L6 9246 RNAseq 1.3469 0.0150
TCGA UBE2L6 9246 RNAseq 0.4169 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by UBE2L6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UBE2L6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UBE2L6 9246 2 3 25
GSE20123 UBE2L6 9246 2 3 25
GSE43470 UBE2L6 9246 1 5 37
GSE46452 UBE2L6 9246 9 4 46
GSE47630 UBE2L6 9246 3 8 29
GSE54993 UBE2L6 9246 3 0 67
GSE54994 UBE2L6 9246 5 6 42
GSE60625 UBE2L6 9246 0 3 8
GSE74703 UBE2L6 9246 1 3 32
GSE74704 UBE2L6 9246 2 3 15
TCGA UBE2L6 9246 14 10 72

Total number of gains: 42; Total number of losses: 48; Total Number of normals: 398.  

 

Somatic mutations of UBE2L6:

 

Generating mutation plots.

 

Highly correlated genes for UBE2L6:

 

Showing top 20/670 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UBE2L6IFI350.80250913013
UBE2L6PSMB90.78869813013
UBE2L6CMPK20.762886706
UBE2L6HLA-F0.75998213013
UBE2L6PARP140.749675908
UBE2L6STAT10.74899112011
UBE2L6HLA-B0.74733313013
UBE2L6TAP10.7472111109
UBE2L6USP410.746044303
UBE2L6DDX600.74210313013
UBE2L6IFI440.74185713013
UBE2L6HLA-C0.73703613012
UBE2L6ISG150.73401113011
UBE2L6PSMB80.73357112010
UBE2L6IFIT30.73325613011
UBE2L6CXCL100.73048612011
UBE2L6EPSTI10.721387807
UBE2L6PARP120.72095512011
UBE2L6OAS20.71998612011
UBE2L6OAS30.71196613012

For details and further investigation, click here