| Full name: C-X-C motif chemokine ligand 10 | Alias Symbol: IFI10|IP-10|crg-2|mob-1|C7|gIP-10 | ||
| Type: protein-coding gene | Cytoband: 4q21.1 | ||
| Entrez ID: 3627 | HGNC ID: HGNC:10637 | Ensembl Gene: ENSG00000169245 | OMIM ID: 147310 |
| Drug and gene relationship at DGIdb | |||
CXCL10 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa04620 | Toll-like receptor signaling pathway |
Expression of CXCL10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXCL10 | 3627 | 204533_at | 1.4672 | 0.5181 | |
| GSE20347 | CXCL10 | 3627 | 204533_at | 1.8754 | 0.0013 | |
| GSE23400 | CXCL10 | 3627 | 204533_at | 0.9555 | 0.0000 | |
| GSE26886 | CXCL10 | 3627 | 204533_at | 0.3225 | 0.7760 | |
| GSE29001 | CXCL10 | 3627 | 204533_at | 2.5573 | 0.0014 | |
| GSE38129 | CXCL10 | 3627 | 204533_at | 1.9451 | 0.0000 | |
| GSE45670 | CXCL10 | 3627 | 204533_at | 2.4537 | 0.0066 | |
| GSE53622 | CXCL10 | 3627 | 80540 | 2.8232 | 0.0000 | |
| GSE53624 | CXCL10 | 3627 | 80540 | 2.4326 | 0.0000 | |
| GSE63941 | CXCL10 | 3627 | 204533_at | 0.1885 | 0.8712 | |
| GSE77861 | CXCL10 | 3627 | 204533_at | 0.7210 | 0.1485 | |
| GSE97050 | CXCL10 | 3627 | A_33_P3343175 | 2.1092 | 0.2308 | |
| SRP007169 | CXCL10 | 3627 | RNAseq | 2.0548 | 0.0012 | |
| SRP064894 | CXCL10 | 3627 | RNAseq | 2.2786 | 0.0000 | |
| SRP133303 | CXCL10 | 3627 | RNAseq | 3.8442 | 0.0000 | |
| SRP159526 | CXCL10 | 3627 | RNAseq | 0.4848 | 0.5807 | |
| TCGA | CXCL10 | 3627 | RNAseq | 1.5833 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by CXCL10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CXCL10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXCL10 | 3627 | 2 | 9 | 19 | |
| GSE20123 | CXCL10 | 3627 | 2 | 9 | 19 | |
| GSE43470 | CXCL10 | 3627 | 0 | 13 | 30 | |
| GSE46452 | CXCL10 | 3627 | 1 | 36 | 22 | |
| GSE47630 | CXCL10 | 3627 | 1 | 19 | 20 | |
| GSE54993 | CXCL10 | 3627 | 7 | 0 | 63 | |
| GSE54994 | CXCL10 | 3627 | 0 | 9 | 44 | |
| GSE60625 | CXCL10 | 3627 | 0 | 0 | 11 | |
| GSE74703 | CXCL10 | 3627 | 0 | 11 | 25 | |
| GSE74704 | CXCL10 | 3627 | 2 | 5 | 13 | |
| TCGA | CXCL10 | 3627 | 17 | 30 | 49 |
Total number of gains: 32; Total number of losses: 141; Total Number of normals: 315.
Somatic mutations of CXCL10:
Generating mutation plots.
Highly correlated genes for CXCL10:
Showing top 20/952 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXCL10 | CXCL11 | 0.8973 | 13 | 0 | 13 |
| CXCL10 | CXCL9 | 0.87177 | 12 | 0 | 12 |
| CXCL10 | USP41 | 0.831532 | 3 | 0 | 3 |
| CXCL10 | EPSTI1 | 0.824928 | 7 | 0 | 7 |
| CXCL10 | TAP1 | 0.756553 | 11 | 0 | 10 |
| CXCL10 | GBP1 | 0.743252 | 13 | 0 | 12 |
| CXCL10 | TFEC | 0.73568 | 10 | 0 | 10 |
| CXCL10 | UBE2L6 | 0.730486 | 12 | 0 | 11 |
| CXCL10 | PLA2G7 | 0.709256 | 11 | 0 | 10 |
| CXCL10 | APOBEC3D | 0.705451 | 3 | 0 | 3 |
| CXCL10 | GBP4 | 0.701905 | 8 | 0 | 8 |
| CXCL10 | OAS2 | 0.70152 | 12 | 0 | 11 |
| CXCL10 | ZCCHC7 | 0.700745 | 3 | 0 | 3 |
| CXCL10 | GZMB | 0.699522 | 12 | 0 | 12 |
| CXCL10 | IFI44 | 0.697958 | 13 | 0 | 11 |
| CXCL10 | RSAD2 | 0.69589 | 13 | 0 | 12 |
| CXCL10 | RNF213 | 0.694448 | 5 | 0 | 4 |
| CXCL10 | PARP14 | 0.694055 | 9 | 0 | 8 |
| CXCL10 | IDO1 | 0.693505 | 12 | 0 | 11 |
| CXCL10 | FCGR3A | 0.693026 | 3 | 0 | 3 |
For details and further investigation, click here
