| Full name: deltex E3 ubiquitin ligase 3L | Alias Symbol: BBAP|RNF143 | ||
| Type: protein-coding gene | Cytoband: 3q21.1 | ||
| Entrez ID: 151636 | HGNC ID: HGNC:30323 | Ensembl Gene: ENSG00000163840 | OMIM ID: 613143 |
| Drug and gene relationship at DGIdb | |||
DTX3L involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of DTX3L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DTX3L | 151636 | 225415_at | 0.8266 | 0.1636 | |
| GSE26886 | DTX3L | 151636 | 225415_at | 0.6617 | 0.0034 | |
| GSE45670 | DTX3L | 151636 | 225415_at | 1.3247 | 0.0000 | |
| GSE53622 | DTX3L | 151636 | 22974 | 0.9470 | 0.0000 | |
| GSE53624 | DTX3L | 151636 | 22974 | 0.8617 | 0.0000 | |
| GSE63941 | DTX3L | 151636 | 225415_at | 0.4517 | 0.5809 | |
| GSE77861 | DTX3L | 151636 | 225415_at | 0.1744 | 0.7645 | |
| GSE97050 | DTX3L | 151636 | A_24_P941912 | 0.8890 | 0.0733 | |
| SRP007169 | DTX3L | 151636 | RNAseq | 2.3217 | 0.0002 | |
| SRP008496 | DTX3L | 151636 | RNAseq | 1.7175 | 0.0000 | |
| SRP064894 | DTX3L | 151636 | RNAseq | 1.3415 | 0.0000 | |
| SRP133303 | DTX3L | 151636 | RNAseq | 1.1561 | 0.0000 | |
| SRP159526 | DTX3L | 151636 | RNAseq | 0.0545 | 0.9042 | |
| SRP193095 | DTX3L | 151636 | RNAseq | 1.0061 | 0.0000 | |
| SRP219564 | DTX3L | 151636 | RNAseq | 0.9338 | 0.0234 | |
| TCGA | DTX3L | 151636 | RNAseq | 0.2397 | 0.0002 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by DTX3L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DTX3L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DTX3L | 151636 | 18 | 0 | 12 | |
| GSE20123 | DTX3L | 151636 | 18 | 0 | 12 | |
| GSE43470 | DTX3L | 151636 | 20 | 0 | 23 | |
| GSE46452 | DTX3L | 151636 | 14 | 5 | 40 | |
| GSE47630 | DTX3L | 151636 | 17 | 4 | 19 | |
| GSE54993 | DTX3L | 151636 | 2 | 6 | 62 | |
| GSE54994 | DTX3L | 151636 | 30 | 4 | 19 | |
| GSE60625 | DTX3L | 151636 | 0 | 6 | 5 | |
| GSE74703 | DTX3L | 151636 | 16 | 0 | 20 | |
| GSE74704 | DTX3L | 151636 | 13 | 0 | 7 | |
| TCGA | DTX3L | 151636 | 54 | 6 | 36 |
Total number of gains: 202; Total number of losses: 31; Total Number of normals: 255.
Somatic mutations of DTX3L:
Generating mutation plots.
Highly correlated genes for DTX3L:
Showing top 20/1212 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DTX3L | PARP9 | 0.815236 | 9 | 0 | 9 |
| DTX3L | PARP14 | 0.809278 | 9 | 0 | 8 |
| DTX3L | USP41 | 0.771732 | 3 | 0 | 3 |
| DTX3L | PSME2 | 0.76961 | 3 | 0 | 3 |
| DTX3L | ADAR | 0.760207 | 7 | 0 | 6 |
| DTX3L | HNRNPUL1 | 0.758246 | 3 | 0 | 3 |
| DTX3L | PLXNA1 | 0.754048 | 6 | 0 | 6 |
| DTX3L | XPR1 | 0.752398 | 5 | 0 | 5 |
| DTX3L | AGRN | 0.75094 | 6 | 0 | 6 |
| DTX3L | DNMT1 | 0.746201 | 6 | 0 | 6 |
| DTX3L | MSN | 0.739862 | 5 | 0 | 5 |
| DTX3L | PARP12 | 0.732869 | 8 | 0 | 7 |
| DTX3L | CALR | 0.727322 | 3 | 0 | 3 |
| DTX3L | CKAP2 | 0.726531 | 5 | 0 | 5 |
| DTX3L | XAF1 | 0.724958 | 7 | 0 | 6 |
| DTX3L | SP140 | 0.723348 | 3 | 0 | 3 |
| DTX3L | NMI | 0.720723 | 8 | 0 | 8 |
| DTX3L | ZBTB9 | 0.718985 | 4 | 0 | 4 |
| DTX3L | STAT2 | 0.717068 | 5 | 0 | 4 |
| DTX3L | TAPBP | 0.716711 | 8 | 0 | 7 |
For details and further investigation, click here
