| Full name: nuclear transcription factor Y subunit gamma | Alias Symbol: CBF-C|NF-YC | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 4802 | HGNC ID: HGNC:7806 | Ensembl Gene: ENSG00000066136 | OMIM ID: 605344 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
NFYC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of NFYC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NFYC | 4802 | 202215_s_at | 0.0388 | 0.9545 | |
| GSE20347 | NFYC | 4802 | 202215_s_at | -0.2156 | 0.1902 | |
| GSE23400 | NFYC | 4802 | 202215_s_at | -0.0301 | 0.7763 | |
| GSE26886 | NFYC | 4802 | 202215_s_at | -1.0299 | 0.0000 | |
| GSE29001 | NFYC | 4802 | 202215_s_at | -0.0031 | 0.9918 | |
| GSE38129 | NFYC | 4802 | 202215_s_at | -0.1599 | 0.1993 | |
| GSE45670 | NFYC | 4802 | 202216_x_at | -0.0274 | 0.8447 | |
| GSE53622 | NFYC | 4802 | 72203 | -0.0236 | 0.6821 | |
| GSE53624 | NFYC | 4802 | 72203 | -0.0030 | 0.9605 | |
| GSE63941 | NFYC | 4802 | 211251_x_at | 1.4952 | 0.0001 | |
| GSE77861 | NFYC | 4802 | 202216_x_at | -0.1733 | 0.4150 | |
| GSE97050 | NFYC | 4802 | A_23_P22994 | -0.0486 | 0.8816 | |
| SRP007169 | NFYC | 4802 | RNAseq | -1.0189 | 0.0077 | |
| SRP008496 | NFYC | 4802 | RNAseq | -0.9807 | 0.0000 | |
| SRP064894 | NFYC | 4802 | RNAseq | -0.0420 | 0.7859 | |
| SRP133303 | NFYC | 4802 | RNAseq | -0.1763 | 0.2084 | |
| SRP159526 | NFYC | 4802 | RNAseq | 0.2249 | 0.5840 | |
| SRP193095 | NFYC | 4802 | RNAseq | -0.0751 | 0.4677 | |
| SRP219564 | NFYC | 4802 | RNAseq | 0.1845 | 0.4944 | |
| TCGA | NFYC | 4802 | RNAseq | 0.0525 | 0.3327 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by NFYC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NFYC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NFYC | 4802 | 3 | 4 | 23 | |
| GSE20123 | NFYC | 4802 | 2 | 3 | 25 | |
| GSE43470 | NFYC | 4802 | 7 | 2 | 34 | |
| GSE46452 | NFYC | 4802 | 3 | 1 | 55 | |
| GSE47630 | NFYC | 4802 | 9 | 2 | 29 | |
| GSE54993 | NFYC | 4802 | 0 | 1 | 69 | |
| GSE54994 | NFYC | 4802 | 13 | 2 | 38 | |
| GSE60625 | NFYC | 4802 | 0 | 0 | 11 | |
| GSE74703 | NFYC | 4802 | 6 | 1 | 29 | |
| GSE74704 | NFYC | 4802 | 1 | 0 | 19 | |
| TCGA | NFYC | 4802 | 16 | 16 | 64 |
Total number of gains: 60; Total number of losses: 32; Total Number of normals: 396.
Somatic mutations of NFYC:
Generating mutation plots.
Highly correlated genes for NFYC:
Showing top 20/338 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NFYC | DNAJB1 | 0.787019 | 3 | 0 | 3 |
| NFYC | FAM122A | 0.747914 | 3 | 0 | 3 |
| NFYC | FRMD4B | 0.729023 | 3 | 0 | 3 |
| NFYC | BCAS1 | 0.72503 | 3 | 0 | 3 |
| NFYC | DBI | 0.714374 | 3 | 0 | 3 |
| NFYC | C5orf51 | 0.697205 | 3 | 0 | 3 |
| NFYC | TOPORS | 0.684714 | 3 | 0 | 3 |
| NFYC | STK11IP | 0.684175 | 3 | 0 | 3 |
| NFYC | TMEM79 | 0.684152 | 3 | 0 | 3 |
| NFYC | RNFT2 | 0.681499 | 4 | 0 | 4 |
| NFYC | AKT1S1 | 0.680296 | 4 | 0 | 4 |
| NFYC | CHCHD1 | 0.676226 | 3 | 0 | 3 |
| NFYC | PIK3CB | 0.674006 | 4 | 0 | 4 |
| NFYC | TRMT1 | 0.667921 | 3 | 0 | 3 |
| NFYC | PPL | 0.66187 | 3 | 0 | 3 |
| NFYC | ITGB7 | 0.661196 | 4 | 0 | 4 |
| NFYC | RPS24 | 0.659789 | 3 | 0 | 3 |
| NFYC | RPRD2 | 0.659154 | 3 | 0 | 3 |
| NFYC | SIAH2 | 0.6575 | 4 | 0 | 4 |
| NFYC | HERPUD1 | 0.657385 | 3 | 0 | 3 |
For details and further investigation, click here
