| Full name: A-kinase anchoring protein 13 | Alias Symbol: Ht31|BRX|AKAP-Lbc|c-lbc|PROTO-LB|HA-3|ARHGEF13 | ||
| Type: protein-coding gene | Cytoband: 15q25.3 | ||
| Entrez ID: 11214 | HGNC ID: HGNC:371 | Ensembl Gene: ENSG00000170776 | OMIM ID: 604686 |
| Drug and gene relationship at DGIdb | |||
Expression of AKAP13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP13 | 11214 | 221718_s_at | -0.4288 | 0.1460 | |
| GSE20347 | AKAP13 | 11214 | 221718_s_at | -0.1304 | 0.3954 | |
| GSE23400 | AKAP13 | 11214 | 221718_s_at | -0.2316 | 0.0195 | |
| GSE26886 | AKAP13 | 11214 | 221718_s_at | -0.0901 | 0.6611 | |
| GSE29001 | AKAP13 | 11214 | 209534_x_at | -0.2757 | 0.3612 | |
| GSE38129 | AKAP13 | 11214 | 221718_s_at | -0.2812 | 0.0734 | |
| GSE45670 | AKAP13 | 11214 | 209534_x_at | -0.2811 | 0.0253 | |
| GSE53622 | AKAP13 | 11214 | 9628 | -0.2363 | 0.0002 | |
| GSE53624 | AKAP13 | 11214 | 103304 | -0.3158 | 0.0000 | |
| GSE63941 | AKAP13 | 11214 | 221718_s_at | 1.3361 | 0.0090 | |
| GSE77861 | AKAP13 | 11214 | 221718_s_at | 0.2502 | 0.3759 | |
| GSE97050 | AKAP13 | 11214 | A_24_P142095 | -0.2611 | 0.2311 | |
| SRP007169 | AKAP13 | 11214 | RNAseq | 0.6533 | 0.0428 | |
| SRP008496 | AKAP13 | 11214 | RNAseq | 0.5172 | 0.0483 | |
| SRP064894 | AKAP13 | 11214 | RNAseq | -0.2162 | 0.4324 | |
| SRP133303 | AKAP13 | 11214 | RNAseq | 0.0441 | 0.7934 | |
| SRP159526 | AKAP13 | 11214 | RNAseq | -0.3723 | 0.1767 | |
| SRP193095 | AKAP13 | 11214 | RNAseq | 0.0056 | 0.9714 | |
| SRP219564 | AKAP13 | 11214 | RNAseq | 0.1614 | 0.5443 | |
| TCGA | AKAP13 | 11214 | RNAseq | -0.2614 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AKAP13 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP13 | 11214 | 8 | 1 | 21 | |
| GSE20123 | AKAP13 | 11214 | 8 | 1 | 21 | |
| GSE43470 | AKAP13 | 11214 | 4 | 5 | 34 | |
| GSE46452 | AKAP13 | 11214 | 3 | 7 | 49 | |
| GSE47630 | AKAP13 | 11214 | 8 | 10 | 22 | |
| GSE54993 | AKAP13 | 11214 | 5 | 6 | 59 | |
| GSE54994 | AKAP13 | 11214 | 6 | 6 | 41 | |
| GSE60625 | AKAP13 | 11214 | 4 | 0 | 7 | |
| GSE74703 | AKAP13 | 11214 | 4 | 3 | 29 | |
| GSE74704 | AKAP13 | 11214 | 4 | 1 | 15 | |
| TCGA | AKAP13 | 11214 | 16 | 13 | 67 |
Total number of gains: 70; Total number of losses: 53; Total Number of normals: 365.
Somatic mutations of AKAP13:
Generating mutation plots.
Highly correlated genes for AKAP13:
Showing top 20/197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP13 | TRA2A | 0.678685 | 5 | 0 | 4 |
| AKAP13 | WWP1 | 0.675012 | 4 | 0 | 3 |
| AKAP13 | UBXN7 | 0.674822 | 3 | 0 | 3 |
| AKAP13 | RUFY1 | 0.672248 | 3 | 0 | 3 |
| AKAP13 | POU6F1 | 0.663393 | 4 | 0 | 4 |
| AKAP13 | MYCT1 | 0.661155 | 3 | 0 | 3 |
| AKAP13 | ZNF33A | 0.660468 | 3 | 0 | 3 |
| AKAP13 | ASH1L | 0.660249 | 3 | 0 | 3 |
| AKAP13 | CLK3 | 0.653254 | 4 | 0 | 4 |
| AKAP13 | IRF2BP2 | 0.649165 | 4 | 0 | 3 |
| AKAP13 | FEM1C | 0.647855 | 5 | 0 | 3 |
| AKAP13 | AKAP6 | 0.647501 | 4 | 0 | 3 |
| AKAP13 | CNTD1 | 0.642567 | 4 | 0 | 3 |
| AKAP13 | OPHN1 | 0.640116 | 4 | 0 | 3 |
| AKAP13 | RHOU | 0.637221 | 4 | 0 | 3 |
| AKAP13 | UBE4B | 0.634711 | 4 | 0 | 3 |
| AKAP13 | COG1 | 0.634332 | 3 | 0 | 3 |
| AKAP13 | LATS2 | 0.632984 | 6 | 0 | 4 |
| AKAP13 | ZNF565 | 0.632368 | 4 | 0 | 3 |
| AKAP13 | POLK | 0.63087 | 4 | 0 | 3 |
For details and further investigation, click here
