| Full name: pleckstrin homology like domain family B member 2 | Alias Symbol: LL5beta|FLJ21791|LL5b | ||
| Type: protein-coding gene | Cytoband: 3q13.2 | ||
| Entrez ID: 90102 | HGNC ID: HGNC:29573 | Ensembl Gene: ENSG00000144824 | OMIM ID: 610298 |
| Drug and gene relationship at DGIdb | |||
Expression of PHLDB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHLDB2 | 90102 | 225688_s_at | 0.5917 | 0.5707 | |
| GSE26886 | PHLDB2 | 90102 | 225688_s_at | 3.3822 | 0.0000 | |
| GSE45670 | PHLDB2 | 90102 | 225688_s_at | 0.7354 | 0.0680 | |
| GSE53622 | PHLDB2 | 90102 | 41700 | 1.5471 | 0.0000 | |
| GSE53624 | PHLDB2 | 90102 | 41700 | 1.8541 | 0.0000 | |
| GSE63941 | PHLDB2 | 90102 | 225688_s_at | -0.2060 | 0.8363 | |
| GSE77861 | PHLDB2 | 90102 | 225688_s_at | 3.4888 | 0.0003 | |
| GSE97050 | PHLDB2 | 90102 | A_24_P178065 | 0.9566 | 0.1450 | |
| SRP007169 | PHLDB2 | 90102 | RNAseq | 4.3533 | 0.0000 | |
| SRP008496 | PHLDB2 | 90102 | RNAseq | 4.5004 | 0.0000 | |
| SRP064894 | PHLDB2 | 90102 | RNAseq | 1.2002 | 0.0000 | |
| SRP133303 | PHLDB2 | 90102 | RNAseq | 1.7365 | 0.0000 | |
| SRP159526 | PHLDB2 | 90102 | RNAseq | 1.5293 | 0.0140 | |
| SRP193095 | PHLDB2 | 90102 | RNAseq | 2.6109 | 0.0000 | |
| SRP219564 | PHLDB2 | 90102 | RNAseq | 0.6048 | 0.2828 | |
| TCGA | PHLDB2 | 90102 | RNAseq | 0.1010 | 0.3376 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by PHLDB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHLDB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHLDB2 | 90102 | 19 | 1 | 10 | |
| GSE20123 | PHLDB2 | 90102 | 19 | 1 | 10 | |
| GSE43470 | PHLDB2 | 90102 | 20 | 1 | 22 | |
| GSE46452 | PHLDB2 | 90102 | 12 | 6 | 41 | |
| GSE47630 | PHLDB2 | 90102 | 16 | 6 | 18 | |
| GSE54993 | PHLDB2 | 90102 | 2 | 5 | 63 | |
| GSE54994 | PHLDB2 | 90102 | 29 | 4 | 20 | |
| GSE60625 | PHLDB2 | 90102 | 0 | 6 | 5 | |
| GSE74703 | PHLDB2 | 90102 | 16 | 1 | 19 | |
| GSE74704 | PHLDB2 | 90102 | 13 | 1 | 6 | |
| TCGA | PHLDB2 | 90102 | 52 | 9 | 35 |
Total number of gains: 198; Total number of losses: 41; Total Number of normals: 249.
Somatic mutations of PHLDB2:
Generating mutation plots.
Highly correlated genes for PHLDB2:
Showing top 20/1344 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHLDB2 | DPYSL2 | 0.78691 | 3 | 0 | 3 |
| PHLDB2 | CCDC102B | 0.736653 | 3 | 0 | 3 |
| PHLDB2 | SLC4A2 | 0.735043 | 3 | 0 | 3 |
| PHLDB2 | AKR1B1 | 0.734629 | 5 | 0 | 5 |
| PHLDB2 | KLHL13 | 0.732101 | 6 | 0 | 5 |
| PHLDB2 | SLC20A1 | 0.731901 | 3 | 0 | 3 |
| PHLDB2 | C1orf216 | 0.731128 | 4 | 0 | 4 |
| PHLDB2 | MRC1 | 0.730511 | 3 | 0 | 3 |
| PHLDB2 | GHDC | 0.723052 | 3 | 0 | 3 |
| PHLDB2 | ALKBH6 | 0.720533 | 4 | 0 | 4 |
| PHLDB2 | C1R | 0.72009 | 3 | 0 | 3 |
| PHLDB2 | MFHAS1 | 0.719724 | 7 | 0 | 6 |
| PHLDB2 | SDHAF2 | 0.718243 | 3 | 0 | 3 |
| PHLDB2 | KLF13 | 0.712694 | 4 | 0 | 4 |
| PHLDB2 | PTPRM | 0.712258 | 3 | 0 | 3 |
| PHLDB2 | CD276 | 0.709351 | 4 | 0 | 4 |
| PHLDB2 | FEN1 | 0.707905 | 3 | 0 | 3 |
| PHLDB2 | UGGT1 | 0.707874 | 3 | 0 | 3 |
| PHLDB2 | HOMER3 | 0.706816 | 5 | 0 | 4 |
| PHLDB2 | TMEM132A | 0.704817 | 4 | 0 | 4 |
For details and further investigation, click here
