| Full name: carnitine palmitoyltransferase 1C | Alias Symbol: FLJ23809|CPTIC|CPT1P | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 126129 | HGNC ID: HGNC:18540 | Ensembl Gene: ENSG00000169169 | OMIM ID: 608846 |
| Drug and gene relationship at DGIdb | |||
CPT1C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04152 | AMPK signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway | |
| hsa04922 | Glucagon signaling pathway |
Expression of CPT1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPT1C | 126129 | 227468_at | 0.2530 | 0.1928 | |
| GSE26886 | CPT1C | 126129 | 227468_at | 0.8738 | 0.0003 | |
| GSE45670 | CPT1C | 126129 | 227468_at | 0.2188 | 0.3421 | |
| GSE53622 | CPT1C | 126129 | 12184 | 0.7135 | 0.0000 | |
| GSE53624 | CPT1C | 126129 | 109009 | 1.3391 | 0.0000 | |
| GSE63941 | CPT1C | 126129 | 227468_at | -0.9225 | 0.2755 | |
| GSE77861 | CPT1C | 126129 | 227468_at | 0.0343 | 0.8429 | |
| GSE97050 | CPT1C | 126129 | A_33_P3392391 | 0.6530 | 0.1321 | |
| SRP064894 | CPT1C | 126129 | RNAseq | 1.7115 | 0.0000 | |
| SRP133303 | CPT1C | 126129 | RNAseq | -0.2765 | 0.2138 | |
| SRP159526 | CPT1C | 126129 | RNAseq | 1.3744 | 0.0009 | |
| SRP193095 | CPT1C | 126129 | RNAseq | 0.7400 | 0.0012 | |
| SRP219564 | CPT1C | 126129 | RNAseq | 0.9056 | 0.1132 | |
| TCGA | CPT1C | 126129 | RNAseq | 0.3724 | 0.0458 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CPT1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPT1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPT1C | 126129 | 4 | 4 | 22 | |
| GSE20123 | CPT1C | 126129 | 4 | 3 | 23 | |
| GSE43470 | CPT1C | 126129 | 5 | 11 | 27 | |
| GSE46452 | CPT1C | 126129 | 45 | 1 | 13 | |
| GSE47630 | CPT1C | 126129 | 10 | 6 | 24 | |
| GSE54993 | CPT1C | 126129 | 17 | 4 | 49 | |
| GSE54994 | CPT1C | 126129 | 4 | 14 | 35 | |
| GSE60625 | CPT1C | 126129 | 9 | 0 | 2 | |
| GSE74703 | CPT1C | 126129 | 5 | 7 | 24 | |
| GSE74704 | CPT1C | 126129 | 4 | 1 | 15 | |
| TCGA | CPT1C | 126129 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of CPT1C:
Generating mutation plots.
Highly correlated genes for CPT1C:
Showing top 20/959 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPT1C | FARS2 | 0.80226 | 3 | 0 | 3 |
| CPT1C | LSM6 | 0.779624 | 3 | 0 | 3 |
| CPT1C | PLAGL2 | 0.775196 | 3 | 0 | 3 |
| CPT1C | SLC9A1 | 0.766035 | 3 | 0 | 3 |
| CPT1C | SEC22A | 0.763661 | 3 | 0 | 3 |
| CPT1C | SFR1 | 0.763071 | 3 | 0 | 3 |
| CPT1C | SNAPC2 | 0.762501 | 3 | 0 | 3 |
| CPT1C | CRISPLD2 | 0.757041 | 3 | 0 | 3 |
| CPT1C | PAPPA | 0.754148 | 3 | 0 | 3 |
| CPT1C | CARD10 | 0.752226 | 3 | 0 | 3 |
| CPT1C | CASK | 0.749082 | 3 | 0 | 3 |
| CPT1C | METTL23 | 0.748299 | 4 | 0 | 4 |
| CPT1C | TMC7 | 0.740217 | 4 | 0 | 4 |
| CPT1C | MAD2L2 | 0.739318 | 4 | 0 | 3 |
| CPT1C | MRM1 | 0.738977 | 3 | 0 | 3 |
| CPT1C | AKR1B1 | 0.738676 | 3 | 0 | 3 |
| CPT1C | ACY1 | 0.73858 | 3 | 0 | 3 |
| CPT1C | EME1 | 0.738383 | 3 | 0 | 3 |
| CPT1C | PLEKHA4 | 0.737067 | 4 | 0 | 4 |
| CPT1C | AGO1 | 0.736861 | 3 | 0 | 3 |
For details and further investigation, click here
