| Full name: aldo-keto reductase family 1 member D1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 6718 | HGNC ID: HGNC:388 | Ensembl Gene: ENSG00000122787 | OMIM ID: 604741 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AKR1D1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR1D1 | 6718 | 207102_at | 0.0516 | 0.8005 | |
| GSE20347 | AKR1D1 | 6718 | 207102_at | 0.0253 | 0.6126 | |
| GSE23400 | AKR1D1 | 6718 | 207102_at | -0.0504 | 0.0384 | |
| GSE26886 | AKR1D1 | 6718 | 207102_at | -0.0278 | 0.7157 | |
| GSE29001 | AKR1D1 | 6718 | 207102_at | -0.0387 | 0.7948 | |
| GSE38129 | AKR1D1 | 6718 | 207102_at | 0.0266 | 0.5492 | |
| GSE45670 | AKR1D1 | 6718 | 207102_at | 0.0250 | 0.7536 | |
| GSE53622 | AKR1D1 | 6718 | 58886 | 0.2802 | 0.0340 | |
| GSE53624 | AKR1D1 | 6718 | 58886 | 0.5360 | 0.0000 | |
| GSE63941 | AKR1D1 | 6718 | 207102_at | -0.0204 | 0.9068 | |
| GSE77861 | AKR1D1 | 6718 | 207102_at | -0.0347 | 0.6489 | |
| SRP133303 | AKR1D1 | 6718 | RNAseq | -0.0847 | 0.7596 | |
| TCGA | AKR1D1 | 6718 | RNAseq | 1.8635 | 0.2466 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AKR1D1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR1D1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1D1 | 6718 | 4 | 2 | 24 | |
| GSE20123 | AKR1D1 | 6718 | 4 | 2 | 24 | |
| GSE43470 | AKR1D1 | 6718 | 2 | 3 | 38 | |
| GSE46452 | AKR1D1 | 6718 | 7 | 2 | 50 | |
| GSE47630 | AKR1D1 | 6718 | 7 | 4 | 29 | |
| GSE54993 | AKR1D1 | 6718 | 3 | 5 | 62 | |
| GSE54994 | AKR1D1 | 6718 | 6 | 8 | 39 | |
| GSE60625 | AKR1D1 | 6718 | 0 | 0 | 11 | |
| GSE74703 | AKR1D1 | 6718 | 2 | 3 | 31 | |
| GSE74704 | AKR1D1 | 6718 | 1 | 2 | 17 | |
| TCGA | AKR1D1 | 6718 | 28 | 23 | 45 |
Total number of gains: 64; Total number of losses: 54; Total Number of normals: 370.
Somatic mutations of AKR1D1:
Generating mutation plots.
Highly correlated genes for AKR1D1:
Showing top 20/89 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1D1 | LINC01281 | 0.728265 | 3 | 0 | 3 |
| AKR1D1 | TMCC1-AS1 | 0.655258 | 4 | 0 | 4 |
| AKR1D1 | CHRNB4 | 0.651968 | 3 | 0 | 3 |
| AKR1D1 | IAPP | 0.642077 | 3 | 0 | 3 |
| AKR1D1 | NUMBL | 0.638928 | 3 | 0 | 3 |
| AKR1D1 | KCNE2 | 0.623167 | 5 | 0 | 4 |
| AKR1D1 | PKLR | 0.614108 | 4 | 0 | 4 |
| AKR1D1 | KRTAP4-7 | 0.613154 | 4 | 0 | 3 |
| AKR1D1 | PDE6C | 0.613057 | 5 | 0 | 4 |
| AKR1D1 | IFNA7 | 0.612813 | 3 | 0 | 3 |
| AKR1D1 | DSCAM-AS1 | 0.60848 | 4 | 0 | 3 |
| AKR1D1 | CLEC1B | 0.602303 | 4 | 0 | 4 |
| AKR1D1 | SPTA1 | 0.601636 | 4 | 0 | 3 |
| AKR1D1 | DMC1 | 0.600636 | 4 | 0 | 3 |
| AKR1D1 | LGALS14 | 0.599279 | 5 | 0 | 5 |
| AKR1D1 | CGA | 0.596987 | 3 | 0 | 3 |
| AKR1D1 | ELOVL3 | 0.595028 | 3 | 0 | 3 |
| AKR1D1 | AQP8 | 0.589164 | 4 | 0 | 4 |
| AKR1D1 | EDDM3A | 0.588062 | 4 | 0 | 3 |
| AKR1D1 | CLDN9 | 0.585724 | 4 | 0 | 3 |
For details and further investigation, click here
