| Full name: islet amyloid polypeptide | Alias Symbol: AMYLIN|DAP|IAP | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 3375 | HGNC ID: HGNC:5329 | Ensembl Gene: ENSG00000121351 | OMIM ID: 147940 |
| Drug and gene relationship at DGIdb | |||
IAPP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of IAPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IAPP | 3375 | 207062_at | 0.0154 | 0.9513 | |
| GSE20347 | IAPP | 3375 | 207062_at | -0.0560 | 0.3974 | |
| GSE23400 | IAPP | 3375 | 207062_at | -0.0404 | 0.3236 | |
| GSE26886 | IAPP | 3375 | 207062_at | 0.1403 | 0.5485 | |
| GSE29001 | IAPP | 3375 | 207062_at | 0.0455 | 0.8512 | |
| GSE38129 | IAPP | 3375 | 207062_at | 0.0571 | 0.6490 | |
| GSE45670 | IAPP | 3375 | 207062_at | 0.0278 | 0.7667 | |
| GSE53622 | IAPP | 3375 | 83175 | 0.4436 | 0.0001 | |
| GSE53624 | IAPP | 3375 | 83175 | -0.0226 | 0.8560 | |
| GSE63941 | IAPP | 3375 | 207062_at | 0.0650 | 0.6402 | |
| GSE77861 | IAPP | 3375 | 207062_at | -0.0186 | 0.8742 | |
| SRP133303 | IAPP | 3375 | RNAseq | 0.6653 | 0.0031 | |
| SRP193095 | IAPP | 3375 | RNAseq | 0.5427 | 0.0045 | |
| TCGA | IAPP | 3375 | RNAseq | 2.5385 | 0.0064 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by IAPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IAPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IAPP | 3375 | 9 | 2 | 19 | |
| GSE20123 | IAPP | 3375 | 9 | 2 | 19 | |
| GSE43470 | IAPP | 3375 | 9 | 4 | 30 | |
| GSE46452 | IAPP | 3375 | 10 | 1 | 48 | |
| GSE47630 | IAPP | 3375 | 14 | 1 | 25 | |
| GSE54993 | IAPP | 3375 | 1 | 9 | 60 | |
| GSE54994 | IAPP | 3375 | 11 | 2 | 40 | |
| GSE60625 | IAPP | 3375 | 0 | 1 | 10 | |
| GSE74703 | IAPP | 3375 | 9 | 3 | 24 | |
| GSE74704 | IAPP | 3375 | 6 | 1 | 13 | |
| TCGA | IAPP | 3375 | 42 | 6 | 48 |
Total number of gains: 120; Total number of losses: 32; Total Number of normals: 336.
Somatic mutations of IAPP:
Generating mutation plots.
Highly correlated genes for IAPP:
Showing top 20/124 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IAPP | INSL5 | 0.722489 | 3 | 0 | 3 |
| IAPP | MYT1L | 0.682532 | 4 | 0 | 4 |
| IAPP | COL4A3 | 0.681473 | 3 | 0 | 3 |
| IAPP | OR6A2 | 0.676782 | 3 | 0 | 3 |
| IAPP | RIT2 | 0.675852 | 4 | 0 | 4 |
| IAPP | GCNT4 | 0.666634 | 3 | 0 | 3 |
| IAPP | MAG | 0.658482 | 3 | 0 | 3 |
| IAPP | CPA2 | 0.655022 | 3 | 0 | 3 |
| IAPP | SPACA1 | 0.650837 | 4 | 0 | 4 |
| IAPP | BRS3 | 0.650564 | 3 | 0 | 3 |
| IAPP | PEX5L | 0.649044 | 3 | 0 | 3 |
| IAPP | OR7E24 | 0.645874 | 4 | 0 | 4 |
| IAPP | GH1 | 0.643682 | 4 | 0 | 4 |
| IAPP | CST8 | 0.642144 | 3 | 0 | 3 |
| IAPP | AKR1D1 | 0.642077 | 3 | 0 | 3 |
| IAPP | LUZP4 | 0.641439 | 3 | 0 | 3 |
| IAPP | USH1C | 0.640074 | 3 | 0 | 3 |
| IAPP | STXBP5L | 0.637647 | 3 | 0 | 3 |
| IAPP | GYPA | 0.635664 | 3 | 0 | 3 |
| IAPP | DGCR6L | 0.629456 | 3 | 0 | 3 |
For details and further investigation, click here
