| Full name: aldehyde dehydrogenase 3 family member A1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 218 | HGNC ID: HGNC:405 | Ensembl Gene: ENSG00000108602 | OMIM ID: 100660 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH3A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH3A1 | 218 | 205623_at | -2.2563 | 0.1725 | |
| GSE20347 | ALDH3A1 | 218 | 205623_at | -1.6570 | 0.0060 | |
| GSE23400 | ALDH3A1 | 218 | 205623_at | -1.5257 | 0.0001 | |
| GSE26886 | ALDH3A1 | 218 | 205623_at | -2.0388 | 0.0053 | |
| GSE29001 | ALDH3A1 | 218 | 205623_at | -2.5455 | 0.0025 | |
| GSE38129 | ALDH3A1 | 218 | 205623_at | -0.7836 | 0.2706 | |
| GSE45670 | ALDH3A1 | 218 | 205623_at | -1.1745 | 0.1252 | |
| GSE53622 | ALDH3A1 | 218 | 42296 | -1.8858 | 0.0000 | |
| GSE53624 | ALDH3A1 | 218 | 42296 | -1.7632 | 0.0000 | |
| GSE63941 | ALDH3A1 | 218 | 205623_at | 4.2500 | 0.0919 | |
| GSE77861 | ALDH3A1 | 218 | 205623_at | -0.4592 | 0.6760 | |
| GSE97050 | ALDH3A1 | 218 | A_33_P3238433 | -0.8203 | 0.2953 | |
| SRP007169 | ALDH3A1 | 218 | RNAseq | -1.1643 | 0.1545 | |
| SRP008496 | ALDH3A1 | 218 | RNAseq | -0.4375 | 0.5876 | |
| SRP064894 | ALDH3A1 | 218 | RNAseq | -2.3007 | 0.0000 | |
| SRP133303 | ALDH3A1 | 218 | RNAseq | -2.4406 | 0.0029 | |
| SRP159526 | ALDH3A1 | 218 | RNAseq | 0.5139 | 0.6089 | |
| SRP193095 | ALDH3A1 | 218 | RNAseq | -1.0076 | 0.0187 | |
| TCGA | ALDH3A1 | 218 | RNAseq | -0.0264 | 0.9310 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by ALDH3A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH3A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH3A1 | 218 | 3 | 3 | 24 | |
| GSE20123 | ALDH3A1 | 218 | 3 | 4 | 23 | |
| GSE43470 | ALDH3A1 | 218 | 1 | 5 | 37 | |
| GSE46452 | ALDH3A1 | 218 | 34 | 1 | 24 | |
| GSE47630 | ALDH3A1 | 218 | 7 | 1 | 32 | |
| GSE54993 | ALDH3A1 | 218 | 3 | 3 | 64 | |
| GSE54994 | ALDH3A1 | 218 | 7 | 6 | 40 | |
| GSE60625 | ALDH3A1 | 218 | 4 | 0 | 7 | |
| GSE74703 | ALDH3A1 | 218 | 1 | 2 | 33 | |
| GSE74704 | ALDH3A1 | 218 | 2 | 1 | 17 | |
| TCGA | ALDH3A1 | 218 | 18 | 24 | 54 |
Total number of gains: 83; Total number of losses: 50; Total Number of normals: 355.
Somatic mutations of ALDH3A1:
Generating mutation plots.
Highly correlated genes for ALDH3A1:
Showing top 20/657 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH3A1 | CYP4F3 | 0.813706 | 12 | 0 | 12 |
| ALDH3A1 | ADH7 | 0.785767 | 13 | 0 | 13 |
| ALDH3A1 | TALDO1 | 0.776167 | 10 | 0 | 10 |
| ALDH3A1 | ALDH3A2 | 0.740598 | 13 | 0 | 13 |
| ALDH3A1 | PGD | 0.720324 | 13 | 0 | 13 |
| ALDH3A1 | PTGR1 | 0.704792 | 8 | 0 | 7 |
| ALDH3A1 | HK1 | 0.700251 | 11 | 0 | 11 |
| ALDH3A1 | UPK3B | 0.694056 | 3 | 0 | 3 |
| ALDH3A1 | SLC9A3R1 | 0.688005 | 13 | 0 | 13 |
| ALDH3A1 | AKR1B10 | 0.683685 | 11 | 0 | 11 |
| ALDH3A1 | DYNLT3 | 0.677502 | 9 | 0 | 8 |
| ALDH3A1 | TMEM246 | 0.67669 | 10 | 0 | 10 |
| ALDH3A1 | ATP13A4 | 0.669578 | 6 | 0 | 6 |
| ALDH3A1 | CYP4F2 | 0.667064 | 13 | 0 | 12 |
| ALDH3A1 | FAM214A | 0.662727 | 4 | 0 | 4 |
| ALDH3A1 | TMPRSS11B | 0.659184 | 5 | 0 | 5 |
| ALDH3A1 | NQO1 | 0.656344 | 11 | 0 | 10 |
| ALDH3A1 | NIPAL1 | 0.656336 | 3 | 0 | 3 |
| ALDH3A1 | DDX1 | 0.654452 | 3 | 0 | 3 |
| ALDH3A1 | TMPRSS4 | 0.653835 | 11 | 0 | 9 |
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