| Full name: aldehyde dehydrogenase 4 family member A1 | Alias Symbol: P5CDh | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 8659 | HGNC ID: HGNC:406 | Ensembl Gene: ENSG00000159423 | OMIM ID: 606811 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH4A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH4A1 | 8659 | 203722_at | -0.2842 | 0.6305 | |
| GSE20347 | ALDH4A1 | 8659 | 203722_at | -0.8402 | 0.0000 | |
| GSE23400 | ALDH4A1 | 8659 | 203722_at | -0.5322 | 0.0000 | |
| GSE26886 | ALDH4A1 | 8659 | 211552_s_at | -0.5095 | 0.0009 | |
| GSE29001 | ALDH4A1 | 8659 | 203722_at | -0.3453 | 0.2909 | |
| GSE38129 | ALDH4A1 | 8659 | 203722_at | -0.6689 | 0.0004 | |
| GSE45670 | ALDH4A1 | 8659 | 203722_at | -0.1136 | 0.5685 | |
| GSE53622 | ALDH4A1 | 8659 | 12788 | -0.3403 | 0.0000 | |
| GSE53624 | ALDH4A1 | 8659 | 12788 | -0.6157 | 0.0000 | |
| GSE63941 | ALDH4A1 | 8659 | 203722_at | 0.0459 | 0.9353 | |
| GSE77861 | ALDH4A1 | 8659 | 211552_s_at | -0.4355 | 0.0290 | |
| GSE97050 | ALDH4A1 | 8659 | A_23_P170337 | -0.3131 | 0.2773 | |
| SRP007169 | ALDH4A1 | 8659 | RNAseq | -1.8460 | 0.0000 | |
| SRP008496 | ALDH4A1 | 8659 | RNAseq | -1.6639 | 0.0000 | |
| SRP064894 | ALDH4A1 | 8659 | RNAseq | -0.3875 | 0.1002 | |
| SRP133303 | ALDH4A1 | 8659 | RNAseq | -1.3700 | 0.0000 | |
| SRP159526 | ALDH4A1 | 8659 | RNAseq | -1.2395 | 0.0004 | |
| SRP193095 | ALDH4A1 | 8659 | RNAseq | -0.8742 | 0.0004 | |
| SRP219564 | ALDH4A1 | 8659 | RNAseq | -1.2154 | 0.0004 | |
| TCGA | ALDH4A1 | 8659 | RNAseq | -0.1478 | 0.0428 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by ALDH4A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH4A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH4A1 | 8659 | 0 | 5 | 25 | |
| GSE20123 | ALDH4A1 | 8659 | 0 | 4 | 26 | |
| GSE43470 | ALDH4A1 | 8659 | 0 | 8 | 35 | |
| GSE46452 | ALDH4A1 | 8659 | 5 | 1 | 53 | |
| GSE47630 | ALDH4A1 | 8659 | 8 | 3 | 29 | |
| GSE54993 | ALDH4A1 | 8659 | 3 | 1 | 66 | |
| GSE54994 | ALDH4A1 | 8659 | 11 | 4 | 38 | |
| GSE60625 | ALDH4A1 | 8659 | 0 | 0 | 11 | |
| GSE74703 | ALDH4A1 | 8659 | 0 | 5 | 31 | |
| GSE74704 | ALDH4A1 | 8659 | 0 | 0 | 20 | |
| TCGA | ALDH4A1 | 8659 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of ALDH4A1:
Generating mutation plots.
Highly correlated genes for ALDH4A1:
Showing top 20/615 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH4A1 | SOCS6 | 0.688346 | 5 | 0 | 5 |
| ALDH4A1 | UTF1 | 0.676621 | 4 | 0 | 4 |
| ALDH4A1 | KRTAP6-3 | 0.673311 | 3 | 0 | 3 |
| ALDH4A1 | LANCL3 | 0.669205 | 3 | 0 | 3 |
| ALDH4A1 | C8orf58 | 0.662131 | 3 | 0 | 3 |
| ALDH4A1 | TTC7A | 0.66144 | 3 | 0 | 3 |
| ALDH4A1 | TMEM9B | 0.651839 | 8 | 0 | 8 |
| ALDH4A1 | ZNF169 | 0.643531 | 3 | 0 | 3 |
| ALDH4A1 | COPZ1 | 0.643428 | 3 | 0 | 3 |
| ALDH4A1 | AKR7A2 | 0.643363 | 7 | 0 | 6 |
| ALDH4A1 | CAPZB | 0.63731 | 8 | 0 | 7 |
| ALDH4A1 | OSBPL8 | 0.637299 | 5 | 0 | 4 |
| ALDH4A1 | DALRD3 | 0.637132 | 7 | 0 | 6 |
| ALDH4A1 | GALK1 | 0.63692 | 4 | 0 | 4 |
| ALDH4A1 | AKR7A3 | 0.633558 | 8 | 0 | 5 |
| ALDH4A1 | IQCF1 | 0.63341 | 3 | 0 | 3 |
| ALDH4A1 | RARG | 0.631185 | 9 | 0 | 7 |
| ALDH4A1 | PLEKHA7 | 0.630186 | 3 | 0 | 3 |
| ALDH4A1 | DEGS2 | 0.628658 | 5 | 0 | 3 |
| ALDH4A1 | ALOX12 | 0.62854 | 8 | 0 | 7 |
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