| Full name: arachidonate 12-lipoxygenase, 12S type | Alias Symbol: 12S-LOX | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 239 | HGNC ID: HGNC:429 | Ensembl Gene: ENSG00000108839 | OMIM ID: 152391 |
| Drug and gene relationship at DGIdb | |||
Expression of ALOX12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALOX12 | 239 | 207206_s_at | -1.3371 | 0.3932 | |
| GSE20347 | ALOX12 | 239 | 207206_s_at | -2.8801 | 0.0000 | |
| GSE23400 | ALOX12 | 239 | 207206_s_at | -2.7294 | 0.0000 | |
| GSE26886 | ALOX12 | 239 | 207206_s_at | -2.7457 | 0.0003 | |
| GSE29001 | ALOX12 | 239 | 207206_s_at | -3.0001 | 0.0001 | |
| GSE38129 | ALOX12 | 239 | 207206_s_at | -2.1667 | 0.0003 | |
| GSE45670 | ALOX12 | 239 | 207206_s_at | -2.3276 | 0.0011 | |
| GSE53622 | ALOX12 | 239 | 63794 | -1.2499 | 0.0000 | |
| GSE53624 | ALOX12 | 239 | 63794 | -1.6669 | 0.0000 | |
| GSE63941 | ALOX12 | 239 | 207206_s_at | 0.7239 | 0.5083 | |
| GSE77861 | ALOX12 | 239 | 207206_s_at | -2.1313 | 0.0231 | |
| GSE97050 | ALOX12 | 239 | A_23_P152906 | -1.6829 | 0.1453 | |
| SRP007169 | ALOX12 | 239 | RNAseq | -6.0931 | 0.0000 | |
| SRP008496 | ALOX12 | 239 | RNAseq | -4.8651 | 0.0000 | |
| SRP064894 | ALOX12 | 239 | RNAseq | -5.4348 | 0.0000 | |
| SRP133303 | ALOX12 | 239 | RNAseq | -3.2522 | 0.0000 | |
| SRP159526 | ALOX12 | 239 | RNAseq | -2.6138 | 0.0001 | |
| SRP193095 | ALOX12 | 239 | RNAseq | -3.9785 | 0.0000 | |
| SRP219564 | ALOX12 | 239 | RNAseq | -4.3557 | 0.0000 | |
| TCGA | ALOX12 | 239 | RNAseq | 0.5440 | 0.0569 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by ALOX12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALOX12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALOX12 | 239 | 4 | 2 | 24 | |
| GSE20123 | ALOX12 | 239 | 4 | 3 | 23 | |
| GSE43470 | ALOX12 | 239 | 1 | 4 | 38 | |
| GSE46452 | ALOX12 | 239 | 34 | 1 | 24 | |
| GSE47630 | ALOX12 | 239 | 7 | 1 | 32 | |
| GSE54993 | ALOX12 | 239 | 4 | 3 | 63 | |
| GSE54994 | ALOX12 | 239 | 5 | 8 | 40 | |
| GSE60625 | ALOX12 | 239 | 4 | 0 | 7 | |
| GSE74703 | ALOX12 | 239 | 1 | 2 | 33 | |
| GSE74704 | ALOX12 | 239 | 2 | 1 | 17 | |
| TCGA | ALOX12 | 239 | 18 | 20 | 58 |
Total number of gains: 84; Total number of losses: 45; Total Number of normals: 359.
Somatic mutations of ALOX12:
Generating mutation plots.
Highly correlated genes for ALOX12:
Showing top 20/1364 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALOX12 | CLIC3 | 0.823522 | 9 | 0 | 9 |
| ALOX12 | GYS2 | 0.813457 | 10 | 0 | 10 |
| ALOX12 | ENDOU | 0.809838 | 11 | 0 | 11 |
| ALOX12 | CRISP3 | 0.800218 | 11 | 0 | 11 |
| ALOX12 | EPS8L1 | 0.797431 | 11 | 0 | 11 |
| ALOX12 | ECM1 | 0.796635 | 11 | 0 | 11 |
| ALOX12 | KRT78 | 0.796194 | 7 | 0 | 7 |
| ALOX12 | FLG | 0.793862 | 11 | 0 | 11 |
| ALOX12 | PRSS3 | 0.792768 | 10 | 0 | 10 |
| ALOX12 | EPS8L2 | 0.792416 | 10 | 0 | 10 |
| ALOX12 | GDPD3 | 0.790861 | 11 | 0 | 11 |
| ALOX12 | EVPL | 0.790071 | 11 | 0 | 11 |
| ALOX12 | TRIP10 | 0.787629 | 11 | 0 | 11 |
| ALOX12 | PADI1 | 0.787614 | 8 | 0 | 8 |
| ALOX12 | PRSS2 | 0.786733 | 8 | 0 | 8 |
| ALOX12 | EHD3 | 0.786553 | 11 | 0 | 11 |
| ALOX12 | CYSRT1 | 0.786495 | 6 | 0 | 6 |
| ALOX12 | UPK1A | 0.786106 | 11 | 0 | 11 |
| ALOX12 | SLURP1 | 0.783491 | 11 | 0 | 11 |
| ALOX12 | ZNRF1 | 0.779044 | 4 | 0 | 4 |
For details and further investigation, click here
