| Full name: ribosomal protein L27a | Alias Symbol: L27A | ||
| Type: protein-coding gene | Cytoband: 11p15 | ||
| Entrez ID: 6157 | HGNC ID: HGNC:10329 | Ensembl Gene: ENSG00000166441 | OMIM ID: 603637 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RPL27A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPL27A | 6157 | 212044_s_at | -0.2656 | 0.6424 | |
| GSE20347 | RPL27A | 6157 | 212044_s_at | -0.4921 | 0.0044 | |
| GSE23400 | RPL27A | 6157 | 212044_s_at | -0.1994 | 0.0029 | |
| GSE26886 | RPL27A | 6157 | 212044_s_at | 0.1393 | 0.7446 | |
| GSE29001 | RPL27A | 6157 | 212044_s_at | -0.5697 | 0.1874 | |
| GSE38129 | RPL27A | 6157 | 212044_s_at | -0.5089 | 0.1851 | |
| GSE45670 | RPL27A | 6157 | 212044_s_at | 0.2201 | 0.1394 | |
| GSE53622 | RPL27A | 6157 | 27815 | -0.5737 | 0.0004 | |
| GSE53624 | RPL27A | 6157 | 27815 | -0.4818 | 0.0001 | |
| GSE63941 | RPL27A | 6157 | 212044_s_at | 0.5906 | 0.0167 | |
| GSE77861 | RPL27A | 6157 | 212044_s_at | -0.0775 | 0.5911 | |
| GSE97050 | RPL27A | 6157 | A_23_P416305 | -0.5309 | 0.1084 | |
| SRP007169 | RPL27A | 6157 | RNAseq | -1.2762 | 0.0003 | |
| SRP008496 | RPL27A | 6157 | RNAseq | -1.0496 | 0.0000 | |
| SRP064894 | RPL27A | 6157 | RNAseq | -0.7832 | 0.0152 | |
| SRP133303 | RPL27A | 6157 | RNAseq | -0.7013 | 0.0000 | |
| SRP159526 | RPL27A | 6157 | RNAseq | -1.0187 | 0.0007 | |
| SRP193095 | RPL27A | 6157 | RNAseq | -1.1181 | 0.0000 | |
| SRP219564 | RPL27A | 6157 | RNAseq | -0.3288 | 0.3855 | |
| TCGA | RPL27A | 6157 | RNAseq | 0.0087 | 0.8726 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RPL27A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPL27A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPL27A | 6157 | 0 | 10 | 20 | |
| GSE20123 | RPL27A | 6157 | 0 | 10 | 20 | |
| GSE43470 | RPL27A | 6157 | 1 | 7 | 35 | |
| GSE46452 | RPL27A | 6157 | 7 | 5 | 47 | |
| GSE47630 | RPL27A | 6157 | 2 | 12 | 26 | |
| GSE54993 | RPL27A | 6157 | 3 | 1 | 66 | |
| GSE54994 | RPL27A | 6157 | 2 | 12 | 39 | |
| GSE60625 | RPL27A | 6157 | 0 | 0 | 11 | |
| GSE74703 | RPL27A | 6157 | 1 | 5 | 30 | |
| GSE74704 | RPL27A | 6157 | 0 | 8 | 12 | |
| TCGA | RPL27A | 6157 | 11 | 34 | 51 |
Total number of gains: 27; Total number of losses: 104; Total Number of normals: 357.
Somatic mutations of RPL27A:
Generating mutation plots.
Highly correlated genes for RPL27A:
Showing top 20/314 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPL27A | MRPL39 | 0.800122 | 3 | 0 | 3 |
| RPL27A | RPLP2 | 0.774951 | 10 | 0 | 9 |
| RPL27A | RPS11 | 0.768853 | 10 | 0 | 10 |
| RPL27A | HERPUD2 | 0.754246 | 3 | 0 | 3 |
| RPL27A | SRSF11 | 0.753206 | 3 | 0 | 3 |
| RPL27A | WIPF2 | 0.750074 | 3 | 0 | 3 |
| RPL27A | BARD1 | 0.747509 | 3 | 0 | 3 |
| RPL27A | TUB | 0.739676 | 3 | 0 | 3 |
| RPL27A | RAB9A | 0.712079 | 3 | 0 | 3 |
| RPL27A | MRPL52 | 0.710208 | 4 | 0 | 4 |
| RPL27A | DYNC1I2 | 0.703222 | 3 | 0 | 3 |
| RPL27A | ALDH7A1 | 0.702481 | 4 | 0 | 4 |
| RPL27A | MAP4K5 | 0.702323 | 3 | 0 | 3 |
| RPL27A | HHLA1 | 0.699116 | 3 | 0 | 3 |
| RPL27A | MATR3 | 0.695213 | 4 | 0 | 4 |
| RPL27A | MITD1 | 0.692469 | 4 | 0 | 4 |
| RPL27A | MRPS25 | 0.687361 | 4 | 0 | 3 |
| RPL27A | PDXDC1 | 0.684311 | 3 | 0 | 3 |
| RPL27A | TBCA | 0.683771 | 5 | 0 | 4 |
| RPL27A | PNP | 0.683536 | 3 | 0 | 3 |
For details and further investigation, click here
