| Full name: ALK receptor tyrosine kinase | Alias Symbol: CD246 | ||
| Type: protein-coding gene | Cytoband: 2p23.2-p23.1 | ||
| Entrez ID: 238 | HGNC ID: HGNC:427 | Ensembl Gene: ENSG00000171094 | OMIM ID: 105590 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ALK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05223 | Non-small cell lung cancer |
Expression of ALK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALK | 238 | 208212_s_at | -0.6840 | 0.0696 | |
| GSE20347 | ALK | 238 | 208212_s_at | -0.1750 | 0.0179 | |
| GSE23400 | ALK | 238 | 208212_s_at | -0.1269 | 0.0136 | |
| GSE26886 | ALK | 238 | 208212_s_at | -0.0417 | 0.8291 | |
| GSE29001 | ALK | 238 | 208212_s_at | -0.3289 | 0.1372 | |
| GSE38129 | ALK | 238 | 208212_s_at | -0.2424 | 0.0039 | |
| GSE45670 | ALK | 238 | 208212_s_at | -0.0458 | 0.8076 | |
| GSE53622 | ALK | 238 | 107522 | -0.5009 | 0.0036 | |
| GSE53624 | ALK | 238 | 107522 | -0.1218 | 0.2687 | |
| GSE63941 | ALK | 238 | 208212_s_at | 0.1636 | 0.8407 | |
| GSE77861 | ALK | 238 | 208212_s_at | -0.3160 | 0.0614 | |
| SRP133303 | ALK | 238 | RNAseq | -1.3904 | 0.0012 | |
| TCGA | ALK | 238 | RNAseq | -1.1422 | 0.0405 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ALK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALK | 238 | 11 | 2 | 17 | |
| GSE20123 | ALK | 238 | 11 | 2 | 17 | |
| GSE43470 | ALK | 238 | 3 | 1 | 39 | |
| GSE46452 | ALK | 238 | 2 | 4 | 53 | |
| GSE47630 | ALK | 238 | 8 | 0 | 32 | |
| GSE54993 | ALK | 238 | 0 | 6 | 64 | |
| GSE54994 | ALK | 238 | 10 | 0 | 43 | |
| GSE60625 | ALK | 238 | 0 | 3 | 8 | |
| GSE74703 | ALK | 238 | 3 | 0 | 33 | |
| GSE74704 | ALK | 238 | 9 | 1 | 10 | |
| TCGA | ALK | 238 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 21; Total Number of normals: 374.
Somatic mutations of ALK:
Generating mutation plots.
Highly correlated genes for ALK:
Showing top 20/474 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALK | FAM95B1 | 0.714896 | 3 | 0 | 3 |
| ALK | EVPLL | 0.692159 | 3 | 0 | 3 |
| ALK | LIPF | 0.679469 | 3 | 0 | 3 |
| ALK | DCTN2 | 0.674489 | 4 | 0 | 3 |
| ALK | TRIM15 | 0.671911 | 6 | 0 | 5 |
| ALK | ONECUT3 | 0.670769 | 3 | 0 | 3 |
| ALK | EZR | 0.665713 | 4 | 0 | 3 |
| ALK | SFTA2 | 0.663099 | 3 | 0 | 3 |
| ALK | ZNF536 | 0.656882 | 3 | 0 | 3 |
| ALK | VRTN | 0.655749 | 5 | 0 | 5 |
| ALK | C5orf66-AS1 | 0.645529 | 3 | 0 | 3 |
| ALK | CACFD1 | 0.645314 | 4 | 0 | 4 |
| ALK | TAS2R9 | 0.642563 | 3 | 0 | 3 |
| ALK | CIITA | 0.640257 | 3 | 0 | 3 |
| ALK | ACTL6B | 0.638777 | 3 | 0 | 3 |
| ALK | SPINK7 | 0.637679 | 3 | 0 | 3 |
| ALK | KNG1 | 0.636489 | 3 | 0 | 3 |
| ALK | GAB2 | 0.636272 | 4 | 0 | 4 |
| ALK | TP53INP2 | 0.635227 | 3 | 0 | 3 |
| ALK | A2ML1 | 0.633767 | 3 | 0 | 3 |
For details and further investigation, click here
