| Full name: phosphoinositide-3-kinase regulatory subunit 4 | Alias Symbol: VPS15|p150 | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 30849 | HGNC ID: HGNC:8982 | Ensembl Gene: ENSG00000196455 | OMIM ID: 602610 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PIK3R4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIK3R4 | 30849 | 212740_at | 0.6462 | 0.1215 | |
| GSE20347 | PIK3R4 | 30849 | 212740_at | 0.7377 | 0.0000 | |
| GSE23400 | PIK3R4 | 30849 | 212740_at | 0.7381 | 0.0000 | |
| GSE26886 | PIK3R4 | 30849 | 212740_at | 0.9165 | 0.0001 | |
| GSE29001 | PIK3R4 | 30849 | 212740_at | 0.8735 | 0.0161 | |
| GSE38129 | PIK3R4 | 30849 | 212740_at | 0.6691 | 0.0000 | |
| GSE45670 | PIK3R4 | 30849 | 212740_at | 0.3260 | 0.0083 | |
| GSE53622 | PIK3R4 | 30849 | 70203 | 0.6535 | 0.0000 | |
| GSE53624 | PIK3R4 | 30849 | 70203 | 0.6503 | 0.0000 | |
| GSE63941 | PIK3R4 | 30849 | 212740_at | 0.0194 | 0.9620 | |
| GSE77861 | PIK3R4 | 30849 | 212740_at | 0.5945 | 0.0169 | |
| GSE97050 | PIK3R4 | 30849 | A_23_P132526 | 0.7470 | 0.0672 | |
| SRP007169 | PIK3R4 | 30849 | RNAseq | 2.1125 | 0.0001 | |
| SRP008496 | PIK3R4 | 30849 | RNAseq | 1.9063 | 0.0000 | |
| SRP064894 | PIK3R4 | 30849 | RNAseq | 0.3706 | 0.0923 | |
| SRP133303 | PIK3R4 | 30849 | RNAseq | 0.7228 | 0.0006 | |
| SRP159526 | PIK3R4 | 30849 | RNAseq | 0.3273 | 0.2173 | |
| SRP193095 | PIK3R4 | 30849 | RNAseq | 0.5332 | 0.0000 | |
| SRP219564 | PIK3R4 | 30849 | RNAseq | 0.0772 | 0.7269 | |
| TCGA | PIK3R4 | 30849 | RNAseq | 0.1329 | 0.0140 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PIK3R4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PIK3R4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIK3R4 | 30849 | 16 | 0 | 14 | |
| GSE20123 | PIK3R4 | 30849 | 16 | 0 | 14 | |
| GSE43470 | PIK3R4 | 30849 | 20 | 0 | 23 | |
| GSE46452 | PIK3R4 | 30849 | 15 | 4 | 40 | |
| GSE47630 | PIK3R4 | 30849 | 18 | 3 | 19 | |
| GSE54993 | PIK3R4 | 30849 | 2 | 8 | 60 | |
| GSE54994 | PIK3R4 | 30849 | 32 | 4 | 17 | |
| GSE60625 | PIK3R4 | 30849 | 0 | 6 | 5 | |
| GSE74703 | PIK3R4 | 30849 | 18 | 0 | 18 | |
| GSE74704 | PIK3R4 | 30849 | 12 | 0 | 8 | |
| TCGA | PIK3R4 | 30849 | 59 | 5 | 32 |
Total number of gains: 208; Total number of losses: 30; Total Number of normals: 250.
Somatic mutations of PIK3R4:
Generating mutation plots.
Highly correlated genes for PIK3R4:
Showing top 20/1518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIK3R4 | SDCCAG8 | 0.83809 | 3 | 0 | 3 |
| PIK3R4 | TOPBP1 | 0.780807 | 12 | 0 | 11 |
| PIK3R4 | ATP2C1 | 0.769415 | 12 | 0 | 12 |
| PIK3R4 | HMCES | 0.756915 | 11 | 0 | 10 |
| PIK3R4 | HLTF | 0.753111 | 11 | 0 | 11 |
| PIK3R4 | MRPL3 | 0.753031 | 12 | 0 | 11 |
| PIK3R4 | ATR | 0.745676 | 11 | 0 | 11 |
| PIK3R4 | RUVBL1 | 0.737154 | 13 | 0 | 11 |
| PIK3R4 | LRRC58 | 0.735491 | 5 | 0 | 4 |
| PIK3R4 | UMPS | 0.735112 | 11 | 0 | 9 |
| PIK3R4 | GTF2E1 | 0.731206 | 12 | 0 | 11 |
| PIK3R4 | U2SURP | 0.722614 | 9 | 0 | 9 |
| PIK3R4 | MCM2 | 0.722034 | 12 | 0 | 11 |
| PIK3R4 | ACTL6A | 0.71944 | 12 | 0 | 11 |
| PIK3R4 | ISY1 | 0.717122 | 5 | 0 | 5 |
| PIK3R4 | NAA50 | 0.716256 | 10 | 0 | 9 |
| PIK3R4 | SPNS1 | 0.707348 | 3 | 0 | 3 |
| PIK3R4 | RFC4 | 0.703689 | 12 | 0 | 11 |
| PIK3R4 | PLXNA1 | 0.701932 | 11 | 0 | 10 |
| PIK3R4 | DHX9 | 0.696671 | 9 | 0 | 8 |
For details and further investigation, click here
