| Full name: phosphodiesterase 4A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 5141 | HGNC ID: HGNC:8780 | Ensembl Gene: ENSG00000065989 | OMIM ID: 600126 |
| Drug and gene relationship at DGIdb | |||
PDE4A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway |
Expression of PDE4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE4A | 5141 | 204735_at | 0.4136 | 0.2917 | |
| GSE20347 | PDE4A | 5141 | 204735_at | 0.6733 | 0.0000 | |
| GSE23400 | PDE4A | 5141 | 204735_at | 0.4338 | 0.0000 | |
| GSE26886 | PDE4A | 5141 | 204735_at | 2.0353 | 0.0000 | |
| GSE29001 | PDE4A | 5141 | 204735_at | 0.7149 | 0.0211 | |
| GSE38129 | PDE4A | 5141 | 204735_at | 0.2681 | 0.3362 | |
| GSE45670 | PDE4A | 5141 | 204735_at | -0.1969 | 0.5609 | |
| GSE63941 | PDE4A | 5141 | 204735_at | -2.2952 | 0.0022 | |
| GSE77861 | PDE4A | 5141 | 211901_s_at | -0.0226 | 0.9311 | |
| GSE97050 | PDE4A | 5141 | A_33_P3395876 | 0.4294 | 0.1807 | |
| SRP007169 | PDE4A | 5141 | RNAseq | 2.2487 | 0.0021 | |
| SRP008496 | PDE4A | 5141 | RNAseq | 3.5041 | 0.0000 | |
| SRP064894 | PDE4A | 5141 | RNAseq | 0.5753 | 0.0118 | |
| SRP133303 | PDE4A | 5141 | RNAseq | 0.4296 | 0.0925 | |
| SRP159526 | PDE4A | 5141 | RNAseq | 0.7141 | 0.1311 | |
| SRP193095 | PDE4A | 5141 | RNAseq | 1.2145 | 0.0000 | |
| SRP219564 | PDE4A | 5141 | RNAseq | 1.3473 | 0.0045 | |
| TCGA | PDE4A | 5141 | RNAseq | -0.3164 | 0.0033 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by PDE4A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PDE4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE4A | 5141 | 4 | 3 | 23 | |
| GSE20123 | PDE4A | 5141 | 3 | 1 | 26 | |
| GSE43470 | PDE4A | 5141 | 3 | 6 | 34 | |
| GSE46452 | PDE4A | 5141 | 47 | 1 | 11 | |
| GSE47630 | PDE4A | 5141 | 4 | 7 | 29 | |
| GSE54993 | PDE4A | 5141 | 16 | 3 | 51 | |
| GSE54994 | PDE4A | 5141 | 7 | 13 | 33 | |
| GSE60625 | PDE4A | 5141 | 9 | 0 | 2 | |
| GSE74703 | PDE4A | 5141 | 3 | 4 | 29 | |
| GSE74704 | PDE4A | 5141 | 0 | 1 | 19 | |
| TCGA | PDE4A | 5141 | 14 | 15 | 67 |
Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.
Somatic mutations of PDE4A:
Generating mutation plots.
Highly correlated genes for PDE4A:
Showing top 20/915 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE4A | SLC9A3R2 | 0.771764 | 3 | 0 | 3 |
| PDE4A | SDK1 | 0.741809 | 3 | 0 | 3 |
| PDE4A | PLXND1 | 0.718972 | 9 | 0 | 9 |
| PDE4A | TMEM263 | 0.716145 | 4 | 0 | 4 |
| PDE4A | TP53I13 | 0.713141 | 3 | 0 | 3 |
| PDE4A | TIMP1 | 0.704595 | 9 | 0 | 8 |
| PDE4A | CTRB2 | 0.700157 | 3 | 0 | 3 |
| PDE4A | FNDC3B | 0.699153 | 7 | 0 | 6 |
| PDE4A | CHSY3 | 0.699047 | 3 | 0 | 3 |
| PDE4A | LBH | 0.693953 | 9 | 0 | 9 |
| PDE4A | CEP120 | 0.691323 | 3 | 0 | 3 |
| PDE4A | GRAMD1A | 0.686 | 4 | 0 | 3 |
| PDE4A | MMD | 0.684749 | 9 | 0 | 9 |
| PDE4A | CTHRC1 | 0.681413 | 5 | 0 | 4 |
| PDE4A | SPOCK1 | 0.680526 | 9 | 0 | 8 |
| PDE4A | NEK6 | 0.67732 | 3 | 0 | 3 |
| PDE4A | ALKBH4 | 0.677199 | 3 | 0 | 3 |
| PDE4A | GDF11 | 0.675929 | 3 | 0 | 3 |
| PDE4A | LGALS1 | 0.675244 | 8 | 0 | 8 |
| PDE4A | GPX8 | 0.674664 | 5 | 0 | 5 |
For details and further investigation, click here
