| Full name: anaphase promoting complex subunit 11 | Alias Symbol: HSPC214|APC11|Apc11p|MGC882 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 51529 | HGNC ID: HGNC:14452 | Ensembl Gene: ENSG00000141552 | OMIM ID: 614534 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ANAPC11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation | |
| hsa05166 | HTLV-I infection |
Expression of ANAPC11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANAPC11 | 51529 | 226414_s_at | 0.4264 | 0.3169 | |
| GSE26886 | ANAPC11 | 51529 | 226414_s_at | 0.0992 | 0.4980 | |
| GSE45670 | ANAPC11 | 51529 | 226414_s_at | 0.1384 | 0.3521 | |
| GSE53622 | ANAPC11 | 51529 | 69928 | 0.1783 | 0.0004 | |
| GSE53624 | ANAPC11 | 51529 | 69928 | 0.4964 | 0.0000 | |
| GSE63941 | ANAPC11 | 51529 | 226414_s_at | 0.3109 | 0.4860 | |
| GSE77861 | ANAPC11 | 51529 | 226414_s_at | 0.1137 | 0.5043 | |
| GSE97050 | ANAPC11 | 51529 | A_23_P27147 | 0.1099 | 0.6668 | |
| SRP007169 | ANAPC11 | 51529 | RNAseq | -0.4759 | 0.1859 | |
| SRP008496 | ANAPC11 | 51529 | RNAseq | -0.5302 | 0.0143 | |
| SRP064894 | ANAPC11 | 51529 | RNAseq | 0.9628 | 0.0164 | |
| SRP133303 | ANAPC11 | 51529 | RNAseq | 0.4168 | 0.0005 | |
| SRP159526 | ANAPC11 | 51529 | RNAseq | 0.6531 | 0.0182 | |
| SRP193095 | ANAPC11 | 51529 | RNAseq | -0.2233 | 0.1017 | |
| SRP219564 | ANAPC11 | 51529 | RNAseq | 0.1358 | 0.7434 | |
| TCGA | ANAPC11 | 51529 | RNAseq | 0.1269 | 0.0183 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ANAPC11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANAPC11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANAPC11 | 51529 | 4 | 4 | 22 | |
| GSE20123 | ANAPC11 | 51529 | 4 | 4 | 22 | |
| GSE43470 | ANAPC11 | 51529 | 3 | 5 | 35 | |
| GSE46452 | ANAPC11 | 51529 | 34 | 0 | 25 | |
| GSE47630 | ANAPC11 | 51529 | 9 | 2 | 29 | |
| GSE54993 | ANAPC11 | 51529 | 2 | 5 | 63 | |
| GSE54994 | ANAPC11 | 51529 | 10 | 6 | 37 | |
| GSE60625 | ANAPC11 | 51529 | 6 | 0 | 5 | |
| GSE74703 | ANAPC11 | 51529 | 3 | 3 | 30 | |
| GSE74704 | ANAPC11 | 51529 | 4 | 3 | 13 | |
| TCGA | ANAPC11 | 51529 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of ANAPC11:
Generating mutation plots.
Highly correlated genes for ANAPC11:
Showing top 20/706 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANAPC11 | RFNG | 0.78164 | 3 | 0 | 3 |
| ANAPC11 | MCMBP | 0.742284 | 3 | 0 | 3 |
| ANAPC11 | C5orf51 | 0.740037 | 3 | 0 | 3 |
| ANAPC11 | CLN6 | 0.737087 | 4 | 0 | 4 |
| ANAPC11 | LSM4 | 0.73602 | 4 | 0 | 4 |
| ANAPC11 | DUS3L | 0.729877 | 3 | 0 | 3 |
| ANAPC11 | ZNF628 | 0.728464 | 4 | 0 | 4 |
| ANAPC11 | MRPL12 | 0.720229 | 6 | 0 | 6 |
| ANAPC11 | METTL23 | 0.714197 | 6 | 0 | 6 |
| ANAPC11 | POLRMT | 0.712131 | 4 | 0 | 3 |
| ANAPC11 | SNF8 | 0.710381 | 4 | 0 | 4 |
| ANAPC11 | MYPOP | 0.698473 | 3 | 0 | 3 |
| ANAPC11 | CHMP7 | 0.6953 | 4 | 0 | 4 |
| ANAPC11 | ELAVL1 | 0.693763 | 4 | 0 | 3 |
| ANAPC11 | BRCA1 | 0.69241 | 6 | 0 | 6 |
| ANAPC11 | ZC3HC1 | 0.691185 | 5 | 0 | 5 |
| ANAPC11 | SLC25A10 | 0.688363 | 5 | 0 | 4 |
| ANAPC11 | MAD2L2 | 0.68655 | 4 | 0 | 3 |
| ANAPC11 | NADSYN1 | 0.684771 | 3 | 0 | 3 |
| ANAPC11 | NASP | 0.682715 | 3 | 0 | 3 |
For details and further investigation, click here
