BRCA1

 

Full name: BRCA1 DNA repair associated Alias Symbol: RNF53|BRCC1|PPP1R53|FANCS
Type: protein-coding gene Cytoband: 17q21.31
Entrez ID: 672 HGNC ID: HGNC:1100 Ensembl Gene: ENSG00000012048 OMIM ID: 113705
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 24/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

BRCA1 involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway

 

Expression of BRCA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BRCA1 672 204531_s_at 0.6388 0.1049
GSE20347 BRCA1 672 204531_s_at 0.9195 0.0000
GSE23400 BRCA1 672 211851_x_at 0.2150 0.0000
GSE26886 BRCA1 672 204531_s_at 1.1904 0.0000
GSE29001 BRCA1 672 204531_s_at 1.3376 0.0001
GSE38129 BRCA1 672 204531_s_at 1.2050 0.0000
GSE45670 BRCA1 672 204531_s_at 1.1717 0.0000
GSE53622 BRCA1 672 18388 0.9428 0.0000
GSE53624 BRCA1 672 22790 1.5834 0.0000
GSE63941 BRCA1 672 204531_s_at 1.1582 0.0246
GSE77861 BRCA1 672 204531_s_at 0.8402 0.0020
GSE97050 BRCA1 672 A_23_P207400 0.5032 0.1657
SRP007169 BRCA1 672 RNAseq 2.2612 0.0000
SRP008496 BRCA1 672 RNAseq 2.0310 0.0000
SRP064894 BRCA1 672 RNAseq 1.2856 0.0000
SRP133303 BRCA1 672 RNAseq 1.2376 0.0000
SRP159526 BRCA1 672 RNAseq 1.1683 0.0003
SRP193095 BRCA1 672 RNAseq 0.9642 0.0000
SRP219564 BRCA1 672 RNAseq 1.0623 0.0105
TCGA BRCA1 672 RNAseq 0.6603 0.0000

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by BRCA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BRCA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BRCA1 672 6 2 22
GSE20123 BRCA1 672 6 2 22
GSE43470 BRCA1 672 1 2 40
GSE46452 BRCA1 672 34 0 25
GSE47630 BRCA1 672 8 1 31
GSE54993 BRCA1 672 3 4 63
GSE54994 BRCA1 672 8 5 40
GSE60625 BRCA1 672 4 0 7
GSE74703 BRCA1 672 1 1 34
GSE74704 BRCA1 672 4 1 15
TCGA BRCA1 672 22 7 67

Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.  

 

Somatic mutations of BRCA1:

 

Generating mutation plots.

 

Highly correlated genes for BRCA1:

 

Showing top 20/2093 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BRCA1ALKBH60.818857404
BRCA1USP340.813585303
BRCA1CDCA20.79615606
BRCA1SCNM10.792878303
BRCA1MCM20.77677811011
BRCA1MTFR20.775968707
BRCA1DTL0.77571912011
BRCA1RPL39L0.77256511011
BRCA1MCM60.7722612011
BRCA1SPAG50.77114112012
BRCA1KNSTRN0.769496707
BRCA1PYCR20.769065303
BRCA1EBNA1BP20.767648303
BRCA1PTCD10.767119303
BRCA1MMS22L0.76469303
BRCA1MCM80.76366808
BRCA1A4GALT0.761295303
BRCA1CEP550.76030612012
BRCA1TK10.75795511010
BRCA1SNRNP2000.756783303

For details and further investigation, click here