| Full name: mitochondrial ribosomal protein L12 | Alias Symbol: MRPL7/L12|MRPL7 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 6182 | HGNC ID: HGNC:10378 | Ensembl Gene: ENSG00000262814 | OMIM ID: 602375 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL12 | 6182 | 203931_s_at | 0.6129 | 0.2250 | |
| GSE20347 | MRPL12 | 6182 | 203931_s_at | 0.2281 | 0.1593 | |
| GSE23400 | MRPL12 | 6182 | 203931_s_at | 0.2015 | 0.0067 | |
| GSE26886 | MRPL12 | 6182 | 203931_s_at | -0.0402 | 0.8293 | |
| GSE29001 | MRPL12 | 6182 | 203931_s_at | 0.1844 | 0.7662 | |
| GSE38129 | MRPL12 | 6182 | 203931_s_at | 0.4381 | 0.0048 | |
| GSE45670 | MRPL12 | 6182 | 203931_s_at | 0.3090 | 0.1125 | |
| GSE63941 | MRPL12 | 6182 | 203931_s_at | 0.8610 | 0.0741 | |
| GSE77861 | MRPL12 | 6182 | 203931_s_at | 0.1135 | 0.6493 | |
| GSE97050 | MRPL12 | 6182 | A_23_P170352 | 0.5084 | 0.1095 | |
| SRP007169 | MRPL12 | 6182 | RNAseq | 0.1762 | 0.6031 | |
| SRP008496 | MRPL12 | 6182 | RNAseq | 0.0199 | 0.9264 | |
| SRP064894 | MRPL12 | 6182 | RNAseq | 0.6582 | 0.0557 | |
| SRP133303 | MRPL12 | 6182 | RNAseq | 0.3030 | 0.0994 | |
| SRP159526 | MRPL12 | 6182 | RNAseq | 0.2669 | 0.1663 | |
| SRP193095 | MRPL12 | 6182 | RNAseq | -0.3273 | 0.0793 | |
| SRP219564 | MRPL12 | 6182 | RNAseq | 0.2038 | 0.6310 | |
| TCGA | MRPL12 | 6182 | RNAseq | 0.1844 | 0.0068 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL12 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRPL12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL12 | 6182 | 4 | 4 | 22 | |
| GSE20123 | MRPL12 | 6182 | 4 | 4 | 22 | |
| GSE43470 | MRPL12 | 6182 | 3 | 5 | 35 | |
| GSE46452 | MRPL12 | 6182 | 34 | 0 | 25 | |
| GSE47630 | MRPL12 | 6182 | 9 | 2 | 29 | |
| GSE54993 | MRPL12 | 6182 | 2 | 5 | 63 | |
| GSE54994 | MRPL12 | 6182 | 10 | 6 | 37 | |
| GSE60625 | MRPL12 | 6182 | 6 | 0 | 5 | |
| GSE74703 | MRPL12 | 6182 | 3 | 3 | 30 | |
| GSE74704 | MRPL12 | 6182 | 4 | 3 | 13 | |
| TCGA | MRPL12 | 6182 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of MRPL12:
Generating mutation plots.
Highly correlated genes for MRPL12:
Showing top 20/555 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL12 | NR2C2AP | 0.747029 | 3 | 0 | 3 |
| MRPL12 | DUS1L | 0.746973 | 8 | 0 | 8 |
| MRPL12 | OTX1 | 0.735015 | 3 | 0 | 3 |
| MRPL12 | ATAD3B | 0.734438 | 3 | 0 | 3 |
| MRPL12 | ANAPC11 | 0.720229 | 6 | 0 | 6 |
| MRPL12 | TUBGCP2 | 0.712571 | 4 | 0 | 4 |
| MRPL12 | ANAPC5 | 0.708117 | 3 | 0 | 3 |
| MRPL12 | CCDC137 | 0.688738 | 5 | 0 | 4 |
| MRPL12 | WDR89 | 0.682463 | 3 | 0 | 3 |
| MRPL12 | SLC39A7 | 0.680473 | 4 | 0 | 4 |
| MRPL12 | DDA1 | 0.677868 | 3 | 0 | 3 |
| MRPL12 | SPC24 | 0.675086 | 4 | 0 | 3 |
| MRPL12 | GPS1 | 0.665785 | 9 | 0 | 8 |
| MRPL12 | MAGOHB | 0.664455 | 5 | 0 | 5 |
| MRPL12 | KIF20B | 0.65972 | 4 | 0 | 3 |
| MRPL12 | STX10 | 0.659247 | 4 | 0 | 3 |
| MRPL12 | CTPS1 | 0.657676 | 3 | 0 | 3 |
| MRPL12 | OXLD1 | 0.655868 | 7 | 0 | 7 |
| MRPL12 | PPIL1 | 0.654788 | 3 | 0 | 3 |
| MRPL12 | ARHGDIA | 0.653365 | 7 | 0 | 6 |
For details and further investigation, click here
