| Full name: CLN6 transmembrane ER protein | Alias Symbol: FLJ20561|HsT18960|nclf | ||
| Type: protein-coding gene | Cytoband: 15q23 | ||
| Entrez ID: 54982 | HGNC ID: HGNC:2077 | Ensembl Gene: ENSG00000128973 | OMIM ID: 606725 |
| Drug and gene relationship at DGIdb | |||
Expression of CLN6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLN6 | 54982 | 1567080_s_at | 0.4461 | 0.3390 | |
| GSE20347 | CLN6 | 54982 | 218161_s_at | 0.4644 | 0.0003 | |
| GSE23400 | CLN6 | 54982 | 218161_s_at | 0.1921 | 0.0003 | |
| GSE26886 | CLN6 | 54982 | 1567080_s_at | -0.8464 | 0.0065 | |
| GSE29001 | CLN6 | 54982 | 218161_s_at | 0.4470 | 0.0331 | |
| GSE38129 | CLN6 | 54982 | 218161_s_at | 0.6177 | 0.0000 | |
| GSE45670 | CLN6 | 54982 | 1567079_at | 0.0010 | 0.9937 | |
| GSE53622 | CLN6 | 54982 | 20268 | 0.6561 | 0.0000 | |
| GSE53624 | CLN6 | 54982 | 20268 | 0.8948 | 0.0000 | |
| GSE63941 | CLN6 | 54982 | 1567080_s_at | 1.0521 | 0.0042 | |
| GSE77861 | CLN6 | 54982 | 1567079_at | -0.2175 | 0.0766 | |
| GSE97050 | CLN6 | 54982 | A_23_P117797 | 0.3578 | 0.2903 | |
| SRP007169 | CLN6 | 54982 | RNAseq | 1.4976 | 0.0085 | |
| SRP008496 | CLN6 | 54982 | RNAseq | 1.6449 | 0.0004 | |
| SRP064894 | CLN6 | 54982 | RNAseq | 1.1271 | 0.0000 | |
| SRP133303 | CLN6 | 54982 | RNAseq | 0.6219 | 0.0009 | |
| SRP159526 | CLN6 | 54982 | RNAseq | 0.7429 | 0.0010 | |
| SRP193095 | CLN6 | 54982 | RNAseq | 0.5122 | 0.0000 | |
| SRP219564 | CLN6 | 54982 | RNAseq | 1.1756 | 0.0039 | |
| TCGA | CLN6 | 54982 | RNAseq | 0.2795 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CLN6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLN6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLN6 | 54982 | 7 | 1 | 22 | |
| GSE20123 | CLN6 | 54982 | 7 | 1 | 22 | |
| GSE43470 | CLN6 | 54982 | 4 | 6 | 33 | |
| GSE46452 | CLN6 | 54982 | 3 | 7 | 49 | |
| GSE47630 | CLN6 | 54982 | 8 | 10 | 22 | |
| GSE54993 | CLN6 | 54982 | 5 | 6 | 59 | |
| GSE54994 | CLN6 | 54982 | 5 | 7 | 41 | |
| GSE60625 | CLN6 | 54982 | 4 | 0 | 7 | |
| GSE74703 | CLN6 | 54982 | 4 | 3 | 29 | |
| GSE74704 | CLN6 | 54982 | 3 | 1 | 16 | |
| TCGA | CLN6 | 54982 | 10 | 16 | 70 |
Total number of gains: 60; Total number of losses: 58; Total Number of normals: 370.
Somatic mutations of CLN6:
Generating mutation plots.
Highly correlated genes for CLN6:
Showing top 20/419 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLN6 | KTI12 | 0.799186 | 3 | 0 | 3 |
| CLN6 | ZDHHC16 | 0.74338 | 4 | 0 | 4 |
| CLN6 | ANAPC1 | 0.737691 | 3 | 0 | 3 |
| CLN6 | ANAPC11 | 0.737087 | 4 | 0 | 4 |
| CLN6 | SLC35B2 | 0.735199 | 3 | 0 | 3 |
| CLN6 | UBR7 | 0.726688 | 3 | 0 | 3 |
| CLN6 | MYCN | 0.720933 | 3 | 0 | 3 |
| CLN6 | MRPL38 | 0.720274 | 4 | 0 | 4 |
| CLN6 | CDC37 | 0.712172 | 4 | 0 | 3 |
| CLN6 | EBNA1BP2 | 0.704126 | 3 | 0 | 3 |
| CLN6 | DKC1 | 0.701925 | 3 | 0 | 3 |
| CLN6 | MAD2L2 | 0.699474 | 5 | 0 | 5 |
| CLN6 | ZNF740 | 0.697949 | 4 | 0 | 3 |
| CLN6 | CDC14B | 0.69536 | 3 | 0 | 3 |
| CLN6 | ZNF837 | 0.694447 | 4 | 0 | 4 |
| CLN6 | KRT18 | 0.692137 | 3 | 0 | 3 |
| CLN6 | PMS2 | 0.691798 | 3 | 0 | 3 |
| CLN6 | ZNF707 | 0.689916 | 3 | 0 | 3 |
| CLN6 | DHX57 | 0.68887 | 4 | 0 | 3 |
| CLN6 | C7orf50 | 0.688127 | 3 | 0 | 3 |
For details and further investigation, click here
