| Full name: angiopoietin 2 | Alias Symbol: Ang2 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 285 | HGNC ID: HGNC:485 | Ensembl Gene: ENSG00000091879 | OMIM ID: 601922 |
| Related drugs: BEVACIZUMAB, MEDI-3617, NESVACUMAB, REGN-910, RIBAVIRIN, TREBANANIB... [more] | |||
ANGPT2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04066 | HIF-1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of ANGPT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANGPT2 | 285 | 205572_at | 1.0858 | 0.2303 | |
| GSE20347 | ANGPT2 | 285 | 211148_s_at | 0.0633 | 0.3889 | |
| GSE23400 | ANGPT2 | 285 | 211148_s_at | 0.0742 | 0.0139 | |
| GSE26886 | ANGPT2 | 285 | 211148_s_at | 0.1254 | 0.4469 | |
| GSE29001 | ANGPT2 | 285 | 205572_at | 0.7707 | 0.0020 | |
| GSE38129 | ANGPT2 | 285 | 211148_s_at | 0.1695 | 0.1784 | |
| GSE45670 | ANGPT2 | 285 | 205572_at | 0.9203 | 0.0430 | |
| GSE53622 | ANGPT2 | 285 | 44995 | 1.5588 | 0.0000 | |
| GSE53624 | ANGPT2 | 285 | 44995 | 1.6818 | 0.0000 | |
| GSE63941 | ANGPT2 | 285 | 211148_s_at | 0.1532 | 0.3299 | |
| GSE77861 | ANGPT2 | 285 | 211148_s_at | -0.0069 | 0.9593 | |
| GSE97050 | ANGPT2 | 285 | A_23_P60079 | 0.6586 | 0.1413 | |
| SRP007169 | ANGPT2 | 285 | RNAseq | 2.6972 | 0.0002 | |
| SRP008496 | ANGPT2 | 285 | RNAseq | 3.0924 | 0.0000 | |
| SRP064894 | ANGPT2 | 285 | RNAseq | 1.7796 | 0.0000 | |
| SRP133303 | ANGPT2 | 285 | RNAseq | 0.4486 | 0.0226 | |
| SRP159526 | ANGPT2 | 285 | RNAseq | 1.2056 | 0.0008 | |
| SRP193095 | ANGPT2 | 285 | RNAseq | 1.4689 | 0.0000 | |
| SRP219564 | ANGPT2 | 285 | RNAseq | 0.1932 | 0.7256 | |
| TCGA | ANGPT2 | 285 | RNAseq | 0.5169 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by ANGPT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANGPT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANGPT2 | 285 | 4 | 11 | 15 | |
| GSE20123 | ANGPT2 | 285 | 4 | 11 | 15 | |
| GSE43470 | ANGPT2 | 285 | 4 | 10 | 29 | |
| GSE46452 | ANGPT2 | 285 | 12 | 14 | 33 | |
| GSE47630 | ANGPT2 | 285 | 9 | 7 | 24 | |
| GSE54993 | ANGPT2 | 285 | 3 | 14 | 53 | |
| GSE54994 | ANGPT2 | 285 | 9 | 19 | 25 | |
| GSE60625 | ANGPT2 | 285 | 3 | 0 | 8 | |
| GSE74703 | ANGPT2 | 285 | 4 | 8 | 24 | |
| GSE74704 | ANGPT2 | 285 | 3 | 7 | 10 | |
| TCGA | ANGPT2 | 285 | 13 | 40 | 43 |
Total number of gains: 68; Total number of losses: 141; Total Number of normals: 279.
Somatic mutations of ANGPT2:
Generating mutation plots.
Highly correlated genes for ANGPT2:
Showing top 20/1316 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANGPT2 | WDR54 | 0.802192 | 5 | 0 | 5 |
| ANGPT2 | FAM89A | 0.787477 | 3 | 0 | 3 |
| ANGPT2 | NONO | 0.781606 | 3 | 0 | 3 |
| ANGPT2 | HELB | 0.773156 | 3 | 0 | 3 |
| ANGPT2 | SPON2 | 0.765138 | 3 | 0 | 3 |
| ANGPT2 | LRRC8C | 0.764405 | 3 | 0 | 3 |
| ANGPT2 | FCGR3A | 0.759198 | 3 | 0 | 3 |
| ANGPT2 | FADS1 | 0.747807 | 3 | 0 | 3 |
| ANGPT2 | RAB34 | 0.746367 | 3 | 0 | 3 |
| ANGPT2 | PYCR2 | 0.739263 | 3 | 0 | 3 |
| ANGPT2 | ALPK2 | 0.735733 | 3 | 0 | 3 |
| ANGPT2 | SMARCD1 | 0.735632 | 3 | 0 | 3 |
| ANGPT2 | LHFPL2 | 0.735347 | 7 | 0 | 7 |
| ANGPT2 | EDEM1 | 0.730824 | 3 | 0 | 3 |
| ANGPT2 | ABL2 | 0.726331 | 5 | 0 | 4 |
| ANGPT2 | SLC35B2 | 0.724192 | 3 | 0 | 3 |
| ANGPT2 | GNPDA1 | 0.72138 | 6 | 0 | 6 |
| ANGPT2 | TMSB10 | 0.719626 | 5 | 0 | 5 |
| ANGPT2 | GPR84 | 0.718233 | 4 | 0 | 4 |
| ANGPT2 | ZNF707 | 0.71785 | 3 | 0 | 3 |
For details and further investigation, click here
