| Full name: ER degradation enhancing alpha-mannosidase like protein 1 | Alias Symbol: KIAA0212|EDEM | ||
| Type: protein-coding gene | Cytoband: 3p26.1 | ||
| Entrez ID: 9695 | HGNC ID: HGNC:18967 | Ensembl Gene: ENSG00000134109 | OMIM ID: 607673 |
| Drug and gene relationship at DGIdb | |||
Expression of EDEM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDEM1 | 9695 | 203279_at | 0.4213 | 0.3581 | |
| GSE20347 | EDEM1 | 9695 | 203279_at | -0.2989 | 0.0098 | |
| GSE23400 | EDEM1 | 9695 | 203279_at | -0.1922 | 0.0016 | |
| GSE26886 | EDEM1 | 9695 | 203279_at | -1.0426 | 0.0000 | |
| GSE29001 | EDEM1 | 9695 | 203279_at | -0.3567 | 0.1951 | |
| GSE38129 | EDEM1 | 9695 | 203279_at | -0.1209 | 0.3339 | |
| GSE45670 | EDEM1 | 9695 | 203279_at | 0.1373 | 0.2035 | |
| GSE53622 | EDEM1 | 9695 | 16547 | -0.1595 | 0.0969 | |
| GSE53624 | EDEM1 | 9695 | 16547 | -0.4300 | 0.0000 | |
| GSE63941 | EDEM1 | 9695 | 203279_at | -0.6916 | 0.1493 | |
| GSE77861 | EDEM1 | 9695 | 203279_at | -0.0951 | 0.5187 | |
| GSE97050 | EDEM1 | 9695 | A_24_P285768 | 0.5016 | 0.2382 | |
| SRP007169 | EDEM1 | 9695 | RNAseq | -0.0811 | 0.8847 | |
| SRP008496 | EDEM1 | 9695 | RNAseq | -0.4802 | 0.1528 | |
| SRP064894 | EDEM1 | 9695 | RNAseq | -0.3250 | 0.1240 | |
| SRP133303 | EDEM1 | 9695 | RNAseq | 0.0347 | 0.8546 | |
| SRP159526 | EDEM1 | 9695 | RNAseq | -0.4982 | 0.1282 | |
| SRP193095 | EDEM1 | 9695 | RNAseq | -0.6487 | 0.0000 | |
| SRP219564 | EDEM1 | 9695 | RNAseq | -0.6449 | 0.1614 | |
| TCGA | EDEM1 | 9695 | RNAseq | -0.0707 | 0.1798 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EDEM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDEM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDEM1 | 9695 | 1 | 18 | 11 | |
| GSE20123 | EDEM1 | 9695 | 1 | 18 | 11 | |
| GSE43470 | EDEM1 | 9695 | 0 | 21 | 22 | |
| GSE46452 | EDEM1 | 9695 | 2 | 18 | 39 | |
| GSE47630 | EDEM1 | 9695 | 1 | 24 | 15 | |
| GSE54993 | EDEM1 | 9695 | 6 | 1 | 63 | |
| GSE54994 | EDEM1 | 9695 | 1 | 32 | 20 | |
| GSE60625 | EDEM1 | 9695 | 5 | 0 | 6 | |
| GSE74703 | EDEM1 | 9695 | 0 | 18 | 18 | |
| GSE74704 | EDEM1 | 9695 | 1 | 11 | 8 | |
| TCGA | EDEM1 | 9695 | 1 | 68 | 27 |
Total number of gains: 19; Total number of losses: 229; Total Number of normals: 240.
Somatic mutations of EDEM1:
Generating mutation plots.
Highly correlated genes for EDEM1:
Showing top 20/429 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDEM1 | SSH2 | 0.757965 | 3 | 0 | 3 |
| EDEM1 | LMAN1 | 0.755073 | 3 | 0 | 3 |
| EDEM1 | STK38 | 0.738487 | 3 | 0 | 3 |
| EDEM1 | ANGPT2 | 0.730824 | 3 | 0 | 3 |
| EDEM1 | HECW2 | 0.711103 | 3 | 0 | 3 |
| EDEM1 | ATP6V1B2 | 0.711094 | 5 | 0 | 4 |
| EDEM1 | SPATS2L | 0.705427 | 3 | 0 | 3 |
| EDEM1 | ARHGAP27 | 0.702731 | 3 | 0 | 3 |
| EDEM1 | ACTR3 | 0.701512 | 4 | 0 | 3 |
| EDEM1 | CEPT1 | 0.693286 | 5 | 0 | 4 |
| EDEM1 | APOBR | 0.693123 | 3 | 0 | 3 |
| EDEM1 | LPIN2 | 0.68721 | 4 | 0 | 3 |
| EDEM1 | FAM155A | 0.686409 | 3 | 0 | 3 |
| EDEM1 | RNASEK | 0.685633 | 3 | 0 | 3 |
| EDEM1 | NCBP1 | 0.680642 | 3 | 0 | 3 |
| EDEM1 | PFKP | 0.680432 | 3 | 0 | 3 |
| EDEM1 | XPO6 | 0.676814 | 3 | 0 | 3 |
| EDEM1 | UBE2F | 0.674508 | 3 | 0 | 3 |
| EDEM1 | TAGAP | 0.673373 | 4 | 0 | 3 |
| EDEM1 | CD63 | 0.673075 | 3 | 0 | 3 |
For details and further investigation, click here
