| Full name: ankyrin repeat and LEM domain containing 2 | Alias Symbol: LEMD7|Lem4 | ||
| Type: protein-coding gene | Cytoband: 12q24.33 | ||
| Entrez ID: 23141 | HGNC ID: HGNC:29101 | Ensembl Gene: ENSG00000176915 | OMIM ID: 616062 |
| Drug and gene relationship at DGIdb | |||
Expression of ANKLE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANKLE2 | 23141 | 212201_at | 0.4745 | 0.1750 | |
| GSE20347 | ANKLE2 | 23141 | 212201_at | 0.2550 | 0.2445 | |
| GSE23400 | ANKLE2 | 23141 | 212201_at | 0.4061 | 0.0000 | |
| GSE26886 | ANKLE2 | 23141 | 212200_at | -0.0406 | 0.9257 | |
| GSE29001 | ANKLE2 | 23141 | 212200_at | 1.0881 | 0.0014 | |
| GSE38129 | ANKLE2 | 23141 | 212201_at | 0.4073 | 0.0101 | |
| GSE45670 | ANKLE2 | 23141 | 212200_at | 0.7810 | 0.0006 | |
| GSE53622 | ANKLE2 | 23141 | 52288 | 0.7056 | 0.0000 | |
| GSE53624 | ANKLE2 | 23141 | 52288 | 0.7095 | 0.0000 | |
| GSE63941 | ANKLE2 | 23141 | 212201_at | 0.6382 | 0.0455 | |
| GSE77861 | ANKLE2 | 23141 | 212201_at | 0.6088 | 0.0161 | |
| GSE97050 | ANKLE2 | 23141 | A_33_P3329784 | 0.6292 | 0.2372 | |
| SRP007169 | ANKLE2 | 23141 | RNAseq | 0.6358 | 0.0538 | |
| SRP008496 | ANKLE2 | 23141 | RNAseq | 0.7385 | 0.0012 | |
| SRP064894 | ANKLE2 | 23141 | RNAseq | 0.6184 | 0.0014 | |
| SRP133303 | ANKLE2 | 23141 | RNAseq | 0.5575 | 0.0005 | |
| SRP159526 | ANKLE2 | 23141 | RNAseq | 0.1945 | 0.5183 | |
| SRP193095 | ANKLE2 | 23141 | RNAseq | 0.6304 | 0.0000 | |
| SRP219564 | ANKLE2 | 23141 | RNAseq | 0.4339 | 0.3022 | |
| TCGA | ANKLE2 | 23141 | RNAseq | 0.1641 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ANKLE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANKLE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANKLE2 | 23141 | 4 | 5 | 21 | |
| GSE20123 | ANKLE2 | 23141 | 4 | 5 | 21 | |
| GSE43470 | ANKLE2 | 23141 | 3 | 3 | 37 | |
| GSE46452 | ANKLE2 | 23141 | 8 | 3 | 48 | |
| GSE47630 | ANKLE2 | 23141 | 9 | 3 | 28 | |
| GSE54993 | ANKLE2 | 23141 | 0 | 6 | 64 | |
| GSE54994 | ANKLE2 | 23141 | 4 | 8 | 41 | |
| GSE60625 | ANKLE2 | 23141 | 1 | 0 | 10 | |
| GSE74703 | ANKLE2 | 23141 | 2 | 3 | 31 | |
| GSE74704 | ANKLE2 | 23141 | 2 | 3 | 15 | |
| TCGA | ANKLE2 | 23141 | 21 | 15 | 60 |
Total number of gains: 58; Total number of losses: 54; Total Number of normals: 376.
Somatic mutations of ANKLE2:
Generating mutation plots.
Highly correlated genes for ANKLE2:
Showing top 20/1088 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANKLE2 | DCBLD1 | 0.736792 | 6 | 0 | 5 |
| ANKLE2 | RTKN | 0.73438 | 6 | 0 | 6 |
| ANKLE2 | PPP3CA | 0.714316 | 4 | 0 | 4 |
| ANKLE2 | FMNL2 | 0.702044 | 6 | 0 | 6 |
| ANKLE2 | TTYH3 | 0.697265 | 6 | 0 | 6 |
| ANKLE2 | JAGN1 | 0.696997 | 4 | 0 | 3 |
| ANKLE2 | KCNS2 | 0.688876 | 3 | 0 | 3 |
| ANKLE2 | EME1 | 0.681266 | 5 | 0 | 5 |
| ANKLE2 | SLC39A10 | 0.681266 | 4 | 0 | 4 |
| ANKLE2 | ADCY3 | 0.679871 | 4 | 0 | 4 |
| ANKLE2 | PPP1R14C | 0.678903 | 7 | 0 | 6 |
| ANKLE2 | ADSL | 0.678309 | 3 | 0 | 3 |
| ANKLE2 | TMEM158 | 0.674489 | 3 | 0 | 3 |
| ANKLE2 | SPRY4-IT1 | 0.673026 | 3 | 0 | 3 |
| ANKLE2 | C1orf43 | 0.670542 | 4 | 0 | 3 |
| ANKLE2 | CDCP1 | 0.669629 | 4 | 0 | 3 |
| ANKLE2 | PNPT1 | 0.665121 | 6 | 0 | 6 |
| ANKLE2 | SLC19A1 | 0.663894 | 3 | 0 | 3 |
| ANKLE2 | CDCA2 | 0.661284 | 5 | 0 | 4 |
| ANKLE2 | GPR153 | 0.660022 | 6 | 0 | 5 |
For details and further investigation, click here
