Full name: protein phosphatase 3 catalytic subunit alpha	Alias Symbol: CNA1|PPP2B
Type: protein-coding gene	Cytoband: 4q24
Entrez ID: 5530	HGNC ID: HGNC:9314	Ensembl Gene: ENSG00000138814	OMIM ID: 114105
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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PPP3CA involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04020	Calcium signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04310	Wnt signaling pathway	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04720	Long-term potentiation	View
hsa04724	Glutamatergic synapse	View
hsa04728	Dopaminergic synapse	View
hsa04921	Oxytocin signaling pathway	View
hsa04922	Glucagon signaling pathway	View
hsa04924	Renin secretion	View
hsa05010	Alzheimer's disease	View
hsa05014	Amyotrophic lateral sclerosis (ALS)	View
hsa05031	Amphetamine addiction	View
hsa05152	Tuberculosis	View
hsa05166	HTLV-I infection	View

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Expression of PPP3CA:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	PPP3CA	5530	202429_s_at	0.1435	0.7134	Show
GSE20347	PPP3CA	5530	202425_x_at	0.0758	0.5654	Show
GSE23400	PPP3CA	5530	202425_x_at	0.2596	0.0000	Show
GSE26886	PPP3CA	5530	202425_x_at	0.3209	0.2453	Show
GSE29001	PPP3CA	5530	202425_x_at	0.3365	0.1616	Show
GSE38129	PPP3CA	5530	202425_x_at	0.0137	0.9205	Show
GSE45670	PPP3CA	5530	202429_s_at	-0.2083	0.3086	Show
GSE53622	PPP3CA	5530	43299	0.1015	0.0926	Show
GSE53624	PPP3CA	5530	43299	-0.0246	0.7753	Show
GSE63941	PPP3CA	5530	202457_s_at	-0.1966	0.6023	Show
GSE77861	PPP3CA	5530	202457_s_at	0.4949	0.1789	Show
GSE97050	PPP3CA	5530	A_24_P414371	0.4555	0.2187	Show
SRP007169	PPP3CA	5530	RNAseq	1.1057	0.0054	Show
SRP008496	PPP3CA	5530	RNAseq	1.0035	0.0001	Show
SRP064894	PPP3CA	5530	RNAseq	0.3982	0.0609	Show
SRP133303	PPP3CA	5530	RNAseq	0.4346	0.0339	Show
SRP159526	PPP3CA	5530	RNAseq	0.3900	0.1681	Show
SRP193095	PPP3CA	5530	RNAseq	0.3808	0.0178	Show
SRP219564	PPP3CA	5530	RNAseq	0.2610	0.4515	Show
TCGA	PPP3CA	5530	RNAseq	-0.1163	0.0185	Show

Upregulated datasets: 2; Downregulated datasets: 0.  Download Data

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Survival by PPP3CA expression:

 

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Copy number change of PPP3CA:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	PPP3CA	5530	1	12	17	Show
GSE20123	PPP3CA	5530	1	12	17	Show
GSE43470	PPP3CA	5530	0	13	30	Show
GSE46452	PPP3CA	5530	1	36	22	Show
GSE47630	PPP3CA	5530	0	20	20	Show
GSE54993	PPP3CA	5530	9	0	61	Show
GSE54994	PPP3CA	5530	1	11	41	Show
GSE60625	PPP3CA	5530	0	3	8	Show
GSE74703	PPP3CA	5530	0	11	25	Show
GSE74704	PPP3CA	5530	0	6	14	Show
TCGA	PPP3CA	5530	8	40	48	Show

Total number of gains: 21; Total number of losses: 164; Total Number of normals: 303.  Download Data

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Somatic mutations of PPP3CA:

 

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Highly correlated genes for PPP3CA:

 

Showing top 20/152 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
PPP3CA	HK2	0.729315	3	0	3
PPP3CA	RCC2	0.728525	3	0	3
PPP3CA	PPP1R14C	0.718707	3	0	3
PPP3CA	IRX2	0.718601	3	0	3
PPP3CA	ANKLE2	0.714316	4	0	4
PPP3CA	GTF3C4	0.702283	3	0	3
PPP3CA	CDC45	0.701599	3	0	3
PPP3CA	GTSE1	0.687604	4	0	3
PPP3CA	AP1S3	0.683047	3	0	3
PPP3CA	PRKDC	0.673142	3	0	3
PPP3CA	CLCN5	0.653493	3	0	3
PPP3CA	ENTPD7	0.652511	3	0	3
PPP3CA	MIS18BP1	0.651191	4	0	4
PPP3CA	UHRF1	0.64769	4	0	4
PPP3CA	PRPF4	0.629273	4	0	3
PPP3CA	CASP2	0.621841	3	0	3
PPP3CA	NLN	0.616805	3	0	3
PPP3CA	LIMK2	0.615363	4	0	4
PPP3CA	STEAP1	0.613265	4	0	3
PPP3CA	TM2D2	0.612825	3	0	3

For details and further investigation, click here