MYL9

 

Full name: myosin light chain 9 Alias Symbol: MYRL2|MLC2|LC20|MRLC1
Type: protein-coding gene Cytoband: 20q11.23
Entrez ID: 10398 HGNC ID: HGNC:15754 Ensembl Gene: ENSG00000101335 OMIM ID: 609905
Drug and gene relationship at DGIdb

 

MYL9 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04510Focal adhesion
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04921Oxytocin signaling pathway

 

Expression of MYL9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MYL9 10398 201058_s_at -1.6098 0.3636
GSE20347 MYL9 10398 201058_s_at -0.3975 0.4918
GSE23400 MYL9 10398 201058_s_at -1.2767 0.0000
GSE26886 MYL9 10398 244149_at 0.1362 0.2674
GSE29001 MYL9 10398 201058_s_at -0.4264 0.3656
GSE38129 MYL9 10398 201058_s_at -1.0292 0.1156
GSE45670 MYL9 10398 201058_s_at -3.2446 0.0000
GSE53622 MYL9 10398 37930 -1.4783 0.0000
GSE53624 MYL9 10398 37930 -1.2801 0.0000
GSE63941 MYL9 10398 244149_at -0.1931 0.4716
GSE77861 MYL9 10398 244149_at -0.1534 0.1054
GSE97050 MYL9 10398 A_23_P210425 -1.3393 0.1148
SRP007169 MYL9 10398 RNAseq 3.2674 0.0000
SRP008496 MYL9 10398 RNAseq 4.2477 0.0000
SRP064894 MYL9 10398 RNAseq -1.3314 0.0009
SRP133303 MYL9 10398 RNAseq -1.8142 0.0000
SRP159526 MYL9 10398 RNAseq -1.6061 0.0014
SRP193095 MYL9 10398 RNAseq 0.6477 0.1423
SRP219564 MYL9 10398 RNAseq -1.6887 0.1580
TCGA MYL9 10398 RNAseq -0.4520 0.0008

Upregulated datasets: 2; Downregulated datasets: 7.  

 

Survival by MYL9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MYL9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MYL9 10398 14 2 14
GSE20123 MYL9 10398 14 2 14
GSE43470 MYL9 10398 12 0 31
GSE46452 MYL9 10398 29 0 30
GSE47630 MYL9 10398 24 0 16
GSE54993 MYL9 10398 0 17 53
GSE54994 MYL9 10398 24 0 29
GSE60625 MYL9 10398 0 0 11
GSE74703 MYL9 10398 11 0 25
GSE74704 MYL9 10398 10 1 9
TCGA MYL9 10398 49 3 44

Total number of gains: 187; Total number of losses: 25; Total Number of normals: 276.  

 

Somatic mutations of MYL9:

 

Generating mutation plots.

 

Highly correlated genes for MYL9:

 

Showing top 20/1035 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MYL9MYL50.872915404
MYL9ACTBL20.845606303
MYL9TAGLN0.8393313012
MYL9DES0.82871311011
MYL9AOC30.82510911010
MYL9LMOD10.806812011
MYL9XKR40.806188505
MYL9CYP21A20.805397303
MYL9ATP1A20.8018621009
MYL9FLNC0.79759612012
MYL9PRUNE20.79459511010
MYL9CFL20.791559505
MYL9NCAM10.789679808
MYL9MYOCD0.787914605
MYL9ADAMTS9-AS20.784408404
MYL9ITGA70.784162909
MYL9CHRDL10.783503908
MYL9KANK20.77683412011
MYL9CLEC3B0.776559303
MYL9NEGR10.776045605

For details and further investigation, click here