| Full name: WW and C2 domain containing 1 | Alias Symbol: KIBRA|KIAA0869|PPP1R168 | ||
| Type: protein-coding gene | Cytoband: 5q34 | ||
| Entrez ID: 23286 | HGNC ID: HGNC:29435 | Ensembl Gene: ENSG00000113645 | OMIM ID: 610533 |
| Drug and gene relationship at DGIdb | |||
WWC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of WWC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WWC1 | 23286 | 213085_s_at | -0.3998 | 0.6461 | |
| GSE20347 | WWC1 | 23286 | 213085_s_at | -1.3431 | 0.0000 | |
| GSE23400 | WWC1 | 23286 | 213085_s_at | -1.0601 | 0.0000 | |
| GSE26886 | WWC1 | 23286 | 213085_s_at | -1.1373 | 0.0003 | |
| GSE29001 | WWC1 | 23286 | 213085_s_at | -1.4123 | 0.0001 | |
| GSE38129 | WWC1 | 23286 | 213085_s_at | -0.8705 | 0.0004 | |
| GSE45670 | WWC1 | 23286 | 213085_s_at | -0.7859 | 0.0049 | |
| GSE53622 | WWC1 | 23286 | 68128 | -1.0439 | 0.0000 | |
| GSE53624 | WWC1 | 23286 | 68128 | -1.5537 | 0.0000 | |
| GSE63941 | WWC1 | 23286 | 213085_s_at | 2.8196 | 0.0001 | |
| GSE77861 | WWC1 | 23286 | 213085_s_at | -1.0640 | 0.0025 | |
| GSE97050 | WWC1 | 23286 | A_23_P81392 | -0.0669 | 0.9500 | |
| SRP007169 | WWC1 | 23286 | RNAseq | -2.0883 | 0.0016 | |
| SRP008496 | WWC1 | 23286 | RNAseq | -2.0438 | 0.0000 | |
| SRP064894 | WWC1 | 23286 | RNAseq | -2.3533 | 0.0000 | |
| SRP133303 | WWC1 | 23286 | RNAseq | -1.6011 | 0.0000 | |
| SRP159526 | WWC1 | 23286 | RNAseq | -1.6169 | 0.0000 | |
| SRP193095 | WWC1 | 23286 | RNAseq | -1.3909 | 0.0000 | |
| SRP219564 | WWC1 | 23286 | RNAseq | -1.9130 | 0.0240 | |
| TCGA | WWC1 | 23286 | RNAseq | -0.4340 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 14.
Survival by WWC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WWC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WWC1 | 23286 | 1 | 11 | 18 | |
| GSE20123 | WWC1 | 23286 | 1 | 11 | 18 | |
| GSE43470 | WWC1 | 23286 | 2 | 8 | 33 | |
| GSE46452 | WWC1 | 23286 | 0 | 27 | 32 | |
| GSE47630 | WWC1 | 23286 | 0 | 20 | 20 | |
| GSE54993 | WWC1 | 23286 | 9 | 2 | 59 | |
| GSE54994 | WWC1 | 23286 | 2 | 15 | 36 | |
| GSE60625 | WWC1 | 23286 | 1 | 0 | 10 | |
| GSE74703 | WWC1 | 23286 | 2 | 6 | 28 | |
| GSE74704 | WWC1 | 23286 | 0 | 6 | 14 | |
| TCGA | WWC1 | 23286 | 7 | 37 | 52 |
Total number of gains: 25; Total number of losses: 143; Total Number of normals: 320.
Somatic mutations of WWC1:
Generating mutation plots.
Highly correlated genes for WWC1:
Showing top 20/1304 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WWC1 | MARVELD2 | 0.822559 | 4 | 0 | 4 |
| WWC1 | TMOD3 | 0.815596 | 11 | 0 | 11 |
| WWC1 | GRPEL2 | 0.81482 | 7 | 0 | 7 |
| WWC1 | ARHGAP27 | 0.810747 | 8 | 0 | 8 |
| WWC1 | MPZL3 | 0.804511 | 8 | 0 | 8 |
| WWC1 | EPS8L1 | 0.804179 | 12 | 0 | 12 |
| WWC1 | EPS8L2 | 0.800061 | 10 | 0 | 10 |
| WWC1 | GYS2 | 0.797719 | 10 | 0 | 10 |
| WWC1 | CLIC3 | 0.794762 | 9 | 0 | 9 |
| WWC1 | NIPAL1 | 0.792439 | 3 | 0 | 3 |
| WWC1 | ATG9B | 0.790991 | 7 | 0 | 7 |
| WWC1 | RANBP9 | 0.789376 | 11 | 0 | 11 |
| WWC1 | CWH43 | 0.786623 | 10 | 0 | 10 |
| WWC1 | C1orf116 | 0.78586 | 12 | 0 | 12 |
| WWC1 | SH3GL1 | 0.783322 | 11 | 0 | 11 |
| WWC1 | MXD1 | 0.781261 | 11 | 0 | 10 |
| WWC1 | PADI1 | 0.781254 | 9 | 0 | 9 |
| WWC1 | EVPL | 0.78001 | 12 | 0 | 12 |
| WWC1 | TMEM40 | 0.778974 | 12 | 0 | 12 |
| WWC1 | RBM47 | 0.778332 | 12 | 0 | 12 |
For details and further investigation, click here
