| Full name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | Alias Symbol: FLJ21065|DRAG1 | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 64411 | HGNC ID: HGNC:24097 | Ensembl Gene: ENSG00000120318 | OMIM ID: 606647 |
| Drug and gene relationship at DGIdb | |||
ARAP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04024 | cAMP signaling pathway |
Expression of ARAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARAP3 | 64411 | 218950_at | 0.6118 | 0.1885 | |
| GSE20347 | ARAP3 | 64411 | 218950_at | 0.5340 | 0.0152 | |
| GSE23400 | ARAP3 | 64411 | 218950_at | 0.1880 | 0.0032 | |
| GSE26886 | ARAP3 | 64411 | 218950_at | 1.0840 | 0.0002 | |
| GSE29001 | ARAP3 | 64411 | 218950_at | 0.2983 | 0.1635 | |
| GSE38129 | ARAP3 | 64411 | 218950_at | 0.3341 | 0.1066 | |
| GSE45670 | ARAP3 | 64411 | 218950_at | 0.3472 | 0.1057 | |
| GSE53622 | ARAP3 | 64411 | 94628 | 0.4647 | 0.0000 | |
| GSE53624 | ARAP3 | 64411 | 94628 | 0.7984 | 0.0000 | |
| GSE63941 | ARAP3 | 64411 | 218950_at | 1.0554 | 0.1795 | |
| GSE77861 | ARAP3 | 64411 | 218950_at | 0.6921 | 0.0125 | |
| GSE97050 | ARAP3 | 64411 | A_23_P167389 | 0.3972 | 0.2206 | |
| SRP007169 | ARAP3 | 64411 | RNAseq | 1.5715 | 0.0199 | |
| SRP064894 | ARAP3 | 64411 | RNAseq | 0.8607 | 0.0000 | |
| SRP133303 | ARAP3 | 64411 | RNAseq | 0.3734 | 0.1807 | |
| SRP159526 | ARAP3 | 64411 | RNAseq | 1.1320 | 0.0030 | |
| SRP193095 | ARAP3 | 64411 | RNAseq | 1.3075 | 0.0000 | |
| SRP219564 | ARAP3 | 64411 | RNAseq | 0.8714 | 0.0279 | |
| TCGA | ARAP3 | 64411 | RNAseq | -0.0755 | 0.4135 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ARAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARAP3 | 64411 | 2 | 11 | 17 | |
| GSE20123 | ARAP3 | 64411 | 3 | 11 | 16 | |
| GSE43470 | ARAP3 | 64411 | 2 | 10 | 31 | |
| GSE46452 | ARAP3 | 64411 | 0 | 27 | 32 | |
| GSE47630 | ARAP3 | 64411 | 1 | 19 | 20 | |
| GSE54993 | ARAP3 | 64411 | 9 | 1 | 60 | |
| GSE54994 | ARAP3 | 64411 | 2 | 14 | 37 | |
| GSE60625 | ARAP3 | 64411 | 0 | 0 | 11 | |
| GSE74703 | ARAP3 | 64411 | 2 | 7 | 27 | |
| GSE74704 | ARAP3 | 64411 | 2 | 5 | 13 | |
| TCGA | ARAP3 | 64411 | 3 | 38 | 55 |
Total number of gains: 26; Total number of losses: 143; Total Number of normals: 319.
Somatic mutations of ARAP3:
Generating mutation plots.
Highly correlated genes for ARAP3:
Showing top 20/242 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARAP3 | LURAP1L | 0.708223 | 3 | 0 | 3 |
| ARAP3 | TYMP | 0.702577 | 4 | 0 | 3 |
| ARAP3 | PHLDB2 | 0.663312 | 3 | 0 | 3 |
| ARAP3 | INPP5F | 0.657032 | 4 | 0 | 4 |
| ARAP3 | SIPA1L3 | 0.650037 | 4 | 0 | 3 |
| ARAP3 | BFAR | 0.643049 | 7 | 0 | 6 |
| ARAP3 | COPRS | 0.638066 | 4 | 0 | 3 |
| ARAP3 | ANXA10 | 0.63722 | 3 | 0 | 3 |
| ARAP3 | KLHDC4 | 0.636391 | 4 | 0 | 4 |
| ARAP3 | WRAP73 | 0.635344 | 3 | 0 | 3 |
| ARAP3 | TNS4 | 0.630839 | 5 | 0 | 3 |
| ARAP3 | STIM2 | 0.624376 | 6 | 0 | 5 |
| ARAP3 | ADAMTSL2 | 0.619547 | 4 | 0 | 4 |
| ARAP3 | ADPGK | 0.613764 | 6 | 0 | 4 |
| ARAP3 | TMEM163 | 0.61219 | 4 | 0 | 3 |
| ARAP3 | DPM3 | 0.605597 | 3 | 0 | 3 |
| ARAP3 | ALDH16A1 | 0.603655 | 3 | 0 | 3 |
| ARAP3 | UTP6 | 0.60302 | 4 | 0 | 3 |
| ARAP3 | HS1BP3 | 0.602682 | 3 | 0 | 3 |
| ARAP3 | LRFN1 | 0.600931 | 3 | 0 | 3 |
For details and further investigation, click here
