| Full name: ADP dependent glucokinase | Alias Symbol: DKFZp434B195|ADP-GK | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 83440 | HGNC ID: HGNC:25250 | Ensembl Gene: ENSG00000159322 | OMIM ID: 611861 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ADPGK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADPGK | 83440 | 220980_s_at | 0.5898 | 0.0336 | |
| GSE20347 | ADPGK | 83440 | 220980_s_at | 0.8762 | 0.0000 | |
| GSE23400 | ADPGK | 83440 | 220980_s_at | 0.5206 | 0.0000 | |
| GSE26886 | ADPGK | 83440 | 220980_s_at | 0.7346 | 0.0000 | |
| GSE29001 | ADPGK | 83440 | 220980_s_at | 0.5906 | 0.0026 | |
| GSE38129 | ADPGK | 83440 | 220980_s_at | 0.8565 | 0.0000 | |
| GSE45670 | ADPGK | 83440 | 220980_s_at | 0.4532 | 0.0002 | |
| GSE53622 | ADPGK | 83440 | 138152 | 0.9265 | 0.0000 | |
| GSE53624 | ADPGK | 83440 | 112912 | 0.7849 | 0.0000 | |
| GSE63941 | ADPGK | 83440 | 220980_s_at | -0.4836 | 0.1198 | |
| GSE77861 | ADPGK | 83440 | 220980_s_at | 0.5807 | 0.0496 | |
| GSE97050 | ADPGK | 83440 | A_23_P14716 | 0.8077 | 0.1162 | |
| SRP007169 | ADPGK | 83440 | RNAseq | 1.0417 | 0.0067 | |
| SRP008496 | ADPGK | 83440 | RNAseq | 1.0696 | 0.0001 | |
| SRP064894 | ADPGK | 83440 | RNAseq | 0.7237 | 0.0000 | |
| SRP133303 | ADPGK | 83440 | RNAseq | 0.7244 | 0.0000 | |
| SRP159526 | ADPGK | 83440 | RNAseq | 0.2480 | 0.3260 | |
| SRP193095 | ADPGK | 83440 | RNAseq | 0.5757 | 0.0000 | |
| SRP219564 | ADPGK | 83440 | RNAseq | 0.9965 | 0.0052 | |
| TCGA | ADPGK | 83440 | RNAseq | 0.1662 | 0.0012 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ADPGK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADPGK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADPGK | 83440 | 8 | 0 | 22 | |
| GSE20123 | ADPGK | 83440 | 8 | 0 | 22 | |
| GSE43470 | ADPGK | 83440 | 4 | 6 | 33 | |
| GSE46452 | ADPGK | 83440 | 3 | 7 | 49 | |
| GSE47630 | ADPGK | 83440 | 8 | 10 | 22 | |
| GSE54993 | ADPGK | 83440 | 5 | 6 | 59 | |
| GSE54994 | ADPGK | 83440 | 5 | 8 | 40 | |
| GSE60625 | ADPGK | 83440 | 4 | 4 | 3 | |
| GSE74703 | ADPGK | 83440 | 4 | 3 | 29 | |
| GSE74704 | ADPGK | 83440 | 4 | 0 | 16 | |
| TCGA | ADPGK | 83440 | 12 | 15 | 69 |
Total number of gains: 65; Total number of losses: 59; Total Number of normals: 364.
Somatic mutations of ADPGK:
Generating mutation plots.
Highly correlated genes for ADPGK:
Showing top 20/1228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADPGK | KNSTRN | 0.767235 | 6 | 0 | 6 |
| ADPGK | CASC4 | 0.715672 | 3 | 0 | 3 |
| ADPGK | FANCI | 0.706994 | 11 | 0 | 11 |
| ADPGK | BLM | 0.704193 | 10 | 0 | 10 |
| ADPGK | CABLES2 | 0.703402 | 3 | 0 | 3 |
| ADPGK | FOXM1 | 0.698262 | 11 | 0 | 11 |
| ADPGK | BCAS4 | 0.696772 | 3 | 0 | 3 |
| ADPGK | SIX4 | 0.691614 | 6 | 0 | 6 |
| ADPGK | UHRF1 | 0.689535 | 7 | 0 | 6 |
| ADPGK | FMNL2 | 0.686745 | 6 | 0 | 5 |
| ADPGK | CCT5 | 0.685357 | 7 | 0 | 7 |
| ADPGK | WDR54 | 0.684862 | 6 | 0 | 6 |
| ADPGK | LPCAT1 | 0.684624 | 10 | 0 | 9 |
| ADPGK | BUB1B | 0.68371 | 9 | 0 | 9 |
| ADPGK | HIBADH | 0.682942 | 4 | 0 | 4 |
| ADPGK | ASPM | 0.682317 | 9 | 0 | 9 |
| ADPGK | WDR66 | 0.681791 | 7 | 0 | 6 |
| ADPGK | ACLY | 0.678868 | 9 | 0 | 9 |
| ADPGK | STEAP2 | 0.678597 | 3 | 0 | 3 |
| ADPGK | PLAU | 0.677234 | 10 | 0 | 10 |
For details and further investigation, click here
