| Full name: pantothenate kinase 2 | Alias Symbol: HSS|FLJ11729|PKAN|HARP | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 80025 | HGNC ID: HGNC:15894 | Ensembl Gene: ENSG00000125779 | OMIM ID: 606157 |
| Drug and gene relationship at DGIdb | |||
Expression of PANK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PANK2 | 80025 | 218809_at | -0.2118 | 0.7882 | |
| GSE20347 | PANK2 | 80025 | 218809_at | -0.5363 | 0.0004 | |
| GSE23400 | PANK2 | 80025 | 218809_at | -0.1315 | 0.1684 | |
| GSE26886 | PANK2 | 80025 | 218809_at | -0.8182 | 0.0000 | |
| GSE29001 | PANK2 | 80025 | 218809_at | -0.2599 | 0.2404 | |
| GSE38129 | PANK2 | 80025 | 218809_at | -0.1900 | 0.2535 | |
| GSE45670 | PANK2 | 80025 | 218809_at | -0.1379 | 0.5570 | |
| GSE53622 | PANK2 | 80025 | 78389 | -0.1995 | 0.0044 | |
| GSE53624 | PANK2 | 80025 | 62999 | -0.4971 | 0.0000 | |
| GSE63941 | PANK2 | 80025 | 218809_at | -0.6262 | 0.1251 | |
| GSE77861 | PANK2 | 80025 | 218809_at | -0.4050 | 0.0961 | |
| GSE97050 | PANK2 | 80025 | A_23_P79942 | 0.1814 | 0.4241 | |
| SRP007169 | PANK2 | 80025 | RNAseq | -2.3014 | 0.0000 | |
| SRP008496 | PANK2 | 80025 | RNAseq | -1.7636 | 0.0000 | |
| SRP064894 | PANK2 | 80025 | RNAseq | -0.7828 | 0.0000 | |
| SRP133303 | PANK2 | 80025 | RNAseq | -0.4264 | 0.0000 | |
| SRP159526 | PANK2 | 80025 | RNAseq | -0.3999 | 0.0269 | |
| SRP193095 | PANK2 | 80025 | RNAseq | -0.6678 | 0.0000 | |
| SRP219564 | PANK2 | 80025 | RNAseq | -0.9013 | 0.0304 | |
| TCGA | PANK2 | 80025 | RNAseq | 0.1214 | 0.0376 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PANK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PANK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PANK2 | 80025 | 12 | 3 | 15 | |
| GSE20123 | PANK2 | 80025 | 13 | 3 | 14 | |
| GSE43470 | PANK2 | 80025 | 10 | 1 | 32 | |
| GSE46452 | PANK2 | 80025 | 26 | 1 | 32 | |
| GSE47630 | PANK2 | 80025 | 18 | 4 | 18 | |
| GSE54993 | PANK2 | 80025 | 2 | 14 | 54 | |
| GSE54994 | PANK2 | 80025 | 24 | 2 | 27 | |
| GSE60625 | PANK2 | 80025 | 0 | 0 | 11 | |
| GSE74703 | PANK2 | 80025 | 9 | 1 | 26 | |
| GSE74704 | PANK2 | 80025 | 8 | 1 | 11 | |
| TCGA | PANK2 | 80025 | 39 | 11 | 46 |
Total number of gains: 161; Total number of losses: 41; Total Number of normals: 286.
Somatic mutations of PANK2:
Generating mutation plots.
Highly correlated genes for PANK2:
Showing top 20/617 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PANK2 | CYP4F22 | 0.751131 | 3 | 0 | 3 |
| PANK2 | ARF4 | 0.743494 | 3 | 0 | 3 |
| PANK2 | RNFT1 | 0.713464 | 3 | 0 | 3 |
| PANK2 | FAM95B1 | 0.711163 | 3 | 0 | 3 |
| PANK2 | ANKRD22 | 0.696384 | 5 | 0 | 5 |
| PANK2 | HDHD2 | 0.691868 | 4 | 0 | 4 |
| PANK2 | DNAJC5 | 0.684076 | 6 | 0 | 6 |
| PANK2 | C15orf48 | 0.66636 | 5 | 0 | 5 |
| PANK2 | SLC10A7 | 0.665823 | 4 | 0 | 3 |
| PANK2 | BEX4 | 0.664923 | 4 | 0 | 4 |
| PANK2 | TBC1D20 | 0.664517 | 6 | 0 | 4 |
| PANK2 | PCBP1-AS1 | 0.662562 | 3 | 0 | 3 |
| PANK2 | SDR9C7 | 0.658123 | 4 | 0 | 3 |
| PANK2 | SLC25A51 | 0.647763 | 4 | 0 | 4 |
| PANK2 | ATP6V1C2 | 0.644814 | 4 | 0 | 3 |
| PANK2 | MIEF2 | 0.642602 | 3 | 0 | 3 |
| PANK2 | STK35 | 0.642144 | 6 | 0 | 6 |
| PANK2 | CGNL1 | 0.634237 | 4 | 0 | 3 |
| PANK2 | SPNS2 | 0.63133 | 4 | 0 | 3 |
| PANK2 | ABHD12 | 0.630274 | 5 | 0 | 5 |
For details and further investigation, click here
