| Full name: Rho guanine nucleotide exchange factor 40 | Alias Symbol: solo|FLJ10357 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 55701 | HGNC ID: HGNC:25516 | Ensembl Gene: ENSG00000165801 | OMIM ID: 610018 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF40:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF40 | 55701 | 58780_s_at | 0.4707 | 0.3670 | |
| GSE20347 | ARHGEF40 | 55701 | 58780_s_at | 0.6171 | 0.0035 | |
| GSE23400 | ARHGEF40 | 55701 | 220326_s_at | 0.0835 | 0.1416 | |
| GSE26886 | ARHGEF40 | 55701 | 241627_x_at | -0.3802 | 0.0550 | |
| GSE29001 | ARHGEF40 | 55701 | 58780_s_at | 1.3550 | 0.0430 | |
| GSE38129 | ARHGEF40 | 55701 | 220326_s_at | 0.2051 | 0.2919 | |
| GSE45670 | ARHGEF40 | 55701 | 220326_s_at | -0.1315 | 0.4584 | |
| GSE53622 | ARHGEF40 | 55701 | 133150 | 0.3962 | 0.0000 | |
| GSE53624 | ARHGEF40 | 55701 | 133150 | 0.5955 | 0.0000 | |
| GSE63941 | ARHGEF40 | 55701 | 58780_s_at | -1.8158 | 0.0561 | |
| GSE77861 | ARHGEF40 | 55701 | 220326_s_at | 0.0935 | 0.3541 | |
| GSE97050 | ARHGEF40 | 55701 | A_23_P99661 | 0.0576 | 0.8100 | |
| SRP007169 | ARHGEF40 | 55701 | RNAseq | 1.8067 | 0.0001 | |
| SRP008496 | ARHGEF40 | 55701 | RNAseq | 1.7546 | 0.0000 | |
| SRP064894 | ARHGEF40 | 55701 | RNAseq | 0.8722 | 0.0002 | |
| SRP133303 | ARHGEF40 | 55701 | RNAseq | 0.2464 | 0.4211 | |
| SRP159526 | ARHGEF40 | 55701 | RNAseq | 1.8249 | 0.0032 | |
| SRP193095 | ARHGEF40 | 55701 | RNAseq | 0.9353 | 0.0006 | |
| SRP219564 | ARHGEF40 | 55701 | RNAseq | 0.8594 | 0.1072 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ARHGEF40 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ARHGEF40:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF40 | 55701 | 9 | 3 | 18 | |
| GSE20123 | ARHGEF40 | 55701 | 8 | 3 | 19 | |
| GSE43470 | ARHGEF40 | 55701 | 7 | 1 | 35 | |
| GSE46452 | ARHGEF40 | 55701 | 19 | 2 | 38 | |
| GSE47630 | ARHGEF40 | 55701 | 10 | 10 | 20 | |
| GSE54993 | ARHGEF40 | 55701 | 3 | 11 | 56 | |
| GSE54994 | ARHGEF40 | 55701 | 18 | 5 | 30 | |
| GSE60625 | ARHGEF40 | 55701 | 0 | 2 | 9 | |
| GSE74703 | ARHGEF40 | 55701 | 6 | 1 | 29 | |
| GSE74704 | ARHGEF40 | 55701 | 4 | 2 | 14 | |
| TCGA | ARHGEF40 | 55701 | 27 | 16 | 53 |
Total number of gains: 111; Total number of losses: 56; Total Number of normals: 321.
Somatic mutations of ARHGEF40:
Generating mutation plots.
Highly correlated genes for ARHGEF40:
Showing top 20/489 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF40 | GXYLT2 | 0.70461 | 5 | 0 | 5 |
| ARHGEF40 | FKBP7 | 0.687679 | 5 | 0 | 5 |
| ARHGEF40 | ASPH | 0.665207 | 3 | 0 | 3 |
| ARHGEF40 | ECI2 | 0.663462 | 4 | 0 | 3 |
| ARHGEF40 | GJA1 | 0.663307 | 3 | 0 | 3 |
| ARHGEF40 | GPX8 | 0.657839 | 6 | 0 | 6 |
| ARHGEF40 | WTIP | 0.654927 | 4 | 0 | 3 |
| ARHGEF40 | CCDC181 | 0.65433 | 3 | 0 | 3 |
| ARHGEF40 | CTXN1 | 0.653246 | 3 | 0 | 3 |
| ARHGEF40 | LAMB1 | 0.652021 | 8 | 0 | 6 |
| ARHGEF40 | DCHS1 | 0.651823 | 6 | 0 | 5 |
| ARHGEF40 | ZNF827 | 0.651508 | 4 | 0 | 3 |
| ARHGEF40 | COLEC11 | 0.651215 | 4 | 0 | 4 |
| ARHGEF40 | TM9SF1 | 0.648755 | 3 | 0 | 3 |
| ARHGEF40 | NRN1 | 0.637036 | 4 | 0 | 4 |
| ARHGEF40 | EFEMP2 | 0.636395 | 10 | 0 | 9 |
| ARHGEF40 | CXCL5 | 0.636313 | 4 | 0 | 4 |
| ARHGEF40 | NOL4L | 0.632208 | 4 | 0 | 4 |
| ARHGEF40 | RAB13 | 0.630771 | 4 | 0 | 3 |
| ARHGEF40 | CERS5 | 0.627508 | 3 | 0 | 3 |
For details and further investigation, click here
