| Full name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | Alias Symbol: PAP|KIAA1249|ZG14P|CENTB4 | ||
| Type: protein-coding gene | Cytoband: 8q24.21-q24.22 | ||
| Entrez ID: 50807 | HGNC ID: HGNC:2720 | Ensembl Gene: ENSG00000153317 | OMIM ID: 605953 |
| Drug and gene relationship at DGIdb | |||
ASAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis |
Expression of ASAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASAP1 | 50807 | 224796_at | 0.7969 | 0.0641 | |
| GSE20347 | ASAP1 | 50807 | 221039_s_at | 0.8164 | 0.0003 | |
| GSE23400 | ASAP1 | 50807 | 221039_s_at | 0.5206 | 0.0000 | |
| GSE26886 | ASAP1 | 50807 | 224796_at | 1.6538 | 0.0000 | |
| GSE29001 | ASAP1 | 50807 | 221039_s_at | 0.3391 | 0.0028 | |
| GSE38129 | ASAP1 | 50807 | 221039_s_at | 0.7222 | 0.0000 | |
| GSE45670 | ASAP1 | 50807 | 224791_at | 0.4772 | 0.0770 | |
| GSE53622 | ASAP1 | 50807 | 82990 | 1.0287 | 0.0000 | |
| GSE53624 | ASAP1 | 50807 | 82990 | 1.0611 | 0.0000 | |
| GSE63941 | ASAP1 | 50807 | 224791_at | -1.7232 | 0.0213 | |
| GSE77861 | ASAP1 | 50807 | 224796_at | 1.2037 | 0.0026 | |
| GSE97050 | ASAP1 | 50807 | A_33_P3775007 | 0.6602 | 0.1785 | |
| SRP007169 | ASAP1 | 50807 | RNAseq | 2.0907 | 0.0000 | |
| SRP008496 | ASAP1 | 50807 | RNAseq | 1.9957 | 0.0000 | |
| SRP064894 | ASAP1 | 50807 | RNAseq | 1.0462 | 0.0002 | |
| SRP133303 | ASAP1 | 50807 | RNAseq | 0.7351 | 0.0000 | |
| SRP159526 | ASAP1 | 50807 | RNAseq | 0.6371 | 0.0119 | |
| SRP193095 | ASAP1 | 50807 | RNAseq | 1.1613 | 0.0000 | |
| SRP219564 | ASAP1 | 50807 | RNAseq | 0.3550 | 0.1866 | |
| TCGA | ASAP1 | 50807 | RNAseq | 0.2374 | 0.0001 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by ASAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASAP1 | 50807 | 17 | 0 | 13 | |
| GSE20123 | ASAP1 | 50807 | 17 | 0 | 13 | |
| GSE43470 | ASAP1 | 50807 | 21 | 1 | 21 | |
| GSE46452 | ASAP1 | 50807 | 27 | 0 | 32 | |
| GSE47630 | ASAP1 | 50807 | 24 | 0 | 16 | |
| GSE54993 | ASAP1 | 50807 | 0 | 24 | 46 | |
| GSE54994 | ASAP1 | 50807 | 39 | 1 | 13 | |
| GSE60625 | ASAP1 | 50807 | 0 | 7 | 4 | |
| GSE74703 | ASAP1 | 50807 | 18 | 1 | 17 | |
| GSE74704 | ASAP1 | 50807 | 11 | 0 | 9 | |
| TCGA | ASAP1 | 50807 | 68 | 2 | 26 |
Total number of gains: 242; Total number of losses: 36; Total Number of normals: 210.
Somatic mutations of ASAP1:
Generating mutation plots.
Highly correlated genes for ASAP1:
Showing top 20/1679 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASAP1 | TFDP2 | 0.768818 | 3 | 0 | 3 |
| ASAP1 | FADS1 | 0.766334 | 3 | 0 | 3 |
| ASAP1 | GNG10 | 0.763686 | 3 | 0 | 3 |
| ASAP1 | LPCAT1 | 0.760367 | 11 | 0 | 11 |
| ASAP1 | ENAH | 0.757685 | 12 | 0 | 12 |
| ASAP1 | CD276 | 0.756757 | 4 | 0 | 4 |
| ASAP1 | FNDC3B | 0.749244 | 11 | 0 | 11 |
| ASAP1 | CPT1A | 0.7396 | 3 | 0 | 3 |
| ASAP1 | RAB34 | 0.73927 | 3 | 0 | 3 |
| ASAP1 | RAI14 | 0.732207 | 12 | 0 | 12 |
| ASAP1 | MSN | 0.731131 | 11 | 0 | 11 |
| ASAP1 | WDR81 | 0.727149 | 4 | 0 | 4 |
| ASAP1 | TSC22D1 | 0.726388 | 3 | 0 | 3 |
| ASAP1 | SH3PXD2B | 0.725451 | 7 | 0 | 7 |
| ASAP1 | FMNL2 | 0.723882 | 8 | 0 | 8 |
| ASAP1 | PTK2 | 0.722462 | 11 | 0 | 11 |
| ASAP1 | IDS | 0.721197 | 4 | 0 | 3 |
| ASAP1 | PDE7A | 0.719924 | 7 | 0 | 6 |
| ASAP1 | NXN | 0.719568 | 3 | 0 | 3 |
| ASAP1 | STK3 | 0.715434 | 11 | 0 | 11 |
For details and further investigation, click here
