| Full name: activating signal cointegrator 1 complex subunit 2 | Alias Symbol: ASC1p100|FLJ21588|DKFZp586O0223 | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 84164 | HGNC ID: HGNC:24103 | Ensembl Gene: ENSG00000100325 | OMIM ID: 614216 |
| Drug and gene relationship at DGIdb | |||
Expression of ASCC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASCC2 | 84164 | 215684_s_at | -0.4359 | 0.4943 | |
| GSE20347 | ASCC2 | 84164 | 215684_s_at | -1.4731 | 0.0000 | |
| GSE23400 | ASCC2 | 84164 | 215684_s_at | -0.8883 | 0.0000 | |
| GSE26886 | ASCC2 | 84164 | 215684_s_at | -1.9097 | 0.0000 | |
| GSE29001 | ASCC2 | 84164 | 215684_s_at | -1.5891 | 0.0005 | |
| GSE38129 | ASCC2 | 84164 | 215684_s_at | -1.0988 | 0.0000 | |
| GSE45670 | ASCC2 | 84164 | 215684_s_at | -0.0536 | 0.8706 | |
| GSE53622 | ASCC2 | 84164 | 97747 | -0.9360 | 0.0000 | |
| GSE53624 | ASCC2 | 84164 | 20038 | -0.9198 | 0.0000 | |
| GSE63941 | ASCC2 | 84164 | 215684_s_at | 0.6260 | 0.1091 | |
| GSE77861 | ASCC2 | 84164 | 215684_s_at | -0.9931 | 0.0064 | |
| GSE97050 | ASCC2 | 84164 | A_23_P143643 | -0.2513 | 0.6216 | |
| SRP007169 | ASCC2 | 84164 | RNAseq | -1.7450 | 0.0011 | |
| SRP008496 | ASCC2 | 84164 | RNAseq | -1.4484 | 0.0001 | |
| SRP064894 | ASCC2 | 84164 | RNAseq | -0.8390 | 0.0000 | |
| SRP133303 | ASCC2 | 84164 | RNAseq | -0.7283 | 0.0000 | |
| SRP159526 | ASCC2 | 84164 | RNAseq | -1.1971 | 0.0000 | |
| SRP193095 | ASCC2 | 84164 | RNAseq | -1.1269 | 0.0000 | |
| SRP219564 | ASCC2 | 84164 | RNAseq | -0.2521 | 0.5934 | |
| TCGA | ASCC2 | 84164 | RNAseq | -0.0246 | 0.6042 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by ASCC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASCC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASCC2 | 84164 | 4 | 5 | 21 | |
| GSE20123 | ASCC2 | 84164 | 4 | 4 | 22 | |
| GSE43470 | ASCC2 | 84164 | 4 | 6 | 33 | |
| GSE46452 | ASCC2 | 84164 | 31 | 1 | 27 | |
| GSE47630 | ASCC2 | 84164 | 8 | 5 | 27 | |
| GSE54993 | ASCC2 | 84164 | 3 | 6 | 61 | |
| GSE54994 | ASCC2 | 84164 | 11 | 9 | 33 | |
| GSE60625 | ASCC2 | 84164 | 5 | 0 | 6 | |
| GSE74703 | ASCC2 | 84164 | 4 | 5 | 27 | |
| GSE74704 | ASCC2 | 84164 | 1 | 1 | 18 | |
| TCGA | ASCC2 | 84164 | 27 | 15 | 54 |
Total number of gains: 102; Total number of losses: 57; Total Number of normals: 329.
Somatic mutations of ASCC2:
Generating mutation plots.
Highly correlated genes for ASCC2:
Showing top 20/1716 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASCC2 | EHD3 | 0.818795 | 11 | 0 | 11 |
| ASCC2 | TOM1 | 0.813303 | 13 | 0 | 13 |
| ASCC2 | TP53I3 | 0.809725 | 11 | 0 | 11 |
| ASCC2 | MFSD5 | 0.805897 | 11 | 0 | 11 |
| ASCC2 | SCNN1B | 0.805451 | 10 | 0 | 10 |
| ASCC2 | NIPAL1 | 0.80529 | 3 | 0 | 3 |
| ASCC2 | NAGK | 0.804645 | 11 | 0 | 11 |
| ASCC2 | ECM1 | 0.802272 | 10 | 0 | 10 |
| ASCC2 | EPGN | 0.802075 | 3 | 0 | 3 |
| ASCC2 | WDR26 | 0.799243 | 11 | 0 | 11 |
| ASCC2 | MXD1 | 0.799047 | 10 | 0 | 10 |
| ASCC2 | ULK3 | 0.799035 | 7 | 0 | 7 |
| ASCC2 | ESPL1 | 0.794052 | 10 | 0 | 10 |
| ASCC2 | SNX24 | 0.794008 | 10 | 0 | 10 |
| ASCC2 | RASSF5 | 0.791748 | 6 | 0 | 6 |
| ASCC2 | ENDOU | 0.791444 | 11 | 0 | 11 |
| ASCC2 | GYS2 | 0.789854 | 10 | 0 | 10 |
| ASCC2 | PLIN3 | 0.789138 | 11 | 0 | 11 |
| ASCC2 | RANBP9 | 0.78901 | 11 | 0 | 11 |
| ASCC2 | RABGGTA | 0.787522 | 11 | 0 | 11 |
For details and further investigation, click here
