| Full name: agouti signaling protein | Alias Symbol: ASP | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 434 | HGNC ID: HGNC:745 | Ensembl Gene: ENSG00000101440 | OMIM ID: 600201 |
ASIP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04916 | Melanogenesis |
Expression of ASIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASIP | 434 | 214498_at | -0.0892 | 0.7455 | |
| GSE20347 | ASIP | 434 | 214498_at | -0.0583 | 0.4011 | |
| GSE23400 | ASIP | 434 | 214498_at | -0.0633 | 0.4973 | |
| GSE26886 | ASIP | 434 | 214498_at | -0.1849 | 0.2196 | |
| GSE29001 | ASIP | 434 | 214498_at | -0.1200 | 0.5024 | |
| GSE38129 | ASIP | 434 | 214498_at | 0.0172 | 0.8021 | |
| GSE45670 | ASIP | 434 | 214498_at | 0.1394 | 0.1604 | |
| GSE63941 | ASIP | 434 | 214498_at | 0.3861 | 0.0072 | |
| GSE77861 | ASIP | 434 | 214498_at | -0.0421 | 0.8065 | |
| TCGA | ASIP | 434 | RNAseq | 1.5019 | 0.0173 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ASIP expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ASIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASIP | 434 | 15 | 0 | 15 | |
| GSE20123 | ASIP | 434 | 15 | 0 | 15 | |
| GSE43470 | ASIP | 434 | 12 | 0 | 31 | |
| GSE46452 | ASIP | 434 | 29 | 0 | 30 | |
| GSE47630 | ASIP | 434 | 24 | 1 | 15 | |
| GSE54993 | ASIP | 434 | 0 | 18 | 52 | |
| GSE54994 | ASIP | 434 | 25 | 1 | 27 | |
| GSE60625 | ASIP | 434 | 0 | 0 | 11 | |
| GSE74703 | ASIP | 434 | 11 | 0 | 25 | |
| GSE74704 | ASIP | 434 | 10 | 0 | 10 | |
| TCGA | ASIP | 434 | 51 | 1 | 44 |
Total number of gains: 192; Total number of losses: 21; Total Number of normals: 275.
Somatic mutations of ASIP:
Generating mutation plots.
Highly correlated genes for ASIP:
Showing top 20/105 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASIP | DPEP3 | 0.720618 | 3 | 0 | 3 |
| ASIP | CYP2A6 | 0.695809 | 3 | 0 | 3 |
| ASIP | TNFSF8 | 0.677429 | 4 | 0 | 4 |
| ASIP | PHLDB1 | 0.669334 | 3 | 0 | 3 |
| ASIP | TBXA2R | 0.668226 | 3 | 0 | 3 |
| ASIP | CPA2 | 0.666179 | 3 | 0 | 3 |
| ASIP | TERT | 0.663157 | 4 | 0 | 4 |
| ASIP | DEFA4 | 0.659601 | 3 | 0 | 3 |
| ASIP | HRH4 | 0.658845 | 3 | 0 | 3 |
| ASIP | P2RX6 | 0.647624 | 4 | 0 | 3 |
| ASIP | FUT5 | 0.643707 | 3 | 0 | 3 |
| ASIP | KRT38 | 0.635736 | 4 | 0 | 3 |
| ASIP | SLC22A2 | 0.6217 | 4 | 0 | 3 |
| ASIP | TAC3 | 0.617125 | 4 | 0 | 3 |
| ASIP | PRX | 0.611579 | 3 | 0 | 3 |
| ASIP | LZTS1 | 0.605448 | 4 | 0 | 3 |
| ASIP | CLPS | 0.60478 | 6 | 0 | 4 |
| ASIP | CD5 | 0.60452 | 4 | 0 | 4 |
| ASIP | FAXDC2 | 0.60348 | 3 | 0 | 3 |
| ASIP | TAAR2 | 0.601059 | 3 | 0 | 3 |
For details and further investigation, click here
