| Full name: solute carrier family 22 member 2 | Alias Symbol: OCT2 | ||
| Type: protein-coding gene | Cytoband: 6q25.3 | ||
| Entrez ID: 6582 | HGNC ID: HGNC:10966 | Ensembl Gene: ENSG00000112499 | OMIM ID: 602608 |
| Drug and gene relationship at DGIdb | |||
SLC22A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05231 | Choline metabolism in cancer |
Expression of SLC22A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC22A2 | 6582 | 207429_at | -0.1767 | 0.5662 | |
| GSE20347 | SLC22A2 | 6582 | 207429_at | 0.0443 | 0.5958 | |
| GSE23400 | SLC22A2 | 6582 | 207429_at | -0.1301 | 0.0085 | |
| GSE26886 | SLC22A2 | 6582 | 207429_at | -0.0091 | 0.9539 | |
| GSE29001 | SLC22A2 | 6582 | 207429_at | -0.0780 | 0.7086 | |
| GSE38129 | SLC22A2 | 6582 | 207429_at | -0.1040 | 0.1577 | |
| GSE45670 | SLC22A2 | 6582 | 207429_at | 0.0915 | 0.4092 | |
| GSE53622 | SLC22A2 | 6582 | 4742 | -0.7889 | 0.0001 | |
| GSE53624 | SLC22A2 | 6582 | 4742 | -0.6249 | 0.0000 | |
| GSE63941 | SLC22A2 | 6582 | 207429_at | -0.1459 | 0.2711 | |
| GSE77861 | SLC22A2 | 6582 | 207429_at | 0.0395 | 0.7008 | |
| GSE97050 | SLC22A2 | 6582 | A_23_P111395 | -0.0762 | 0.8668 | |
| TCGA | SLC22A2 | 6582 | RNAseq | 1.5489 | 0.1198 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC22A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC22A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC22A2 | 6582 | 1 | 5 | 24 | |
| GSE20123 | SLC22A2 | 6582 | 1 | 4 | 25 | |
| GSE43470 | SLC22A2 | 6582 | 4 | 0 | 39 | |
| GSE46452 | SLC22A2 | 6582 | 3 | 10 | 46 | |
| GSE47630 | SLC22A2 | 6582 | 9 | 4 | 27 | |
| GSE54993 | SLC22A2 | 6582 | 4 | 4 | 62 | |
| GSE54994 | SLC22A2 | 6582 | 8 | 9 | 36 | |
| GSE60625 | SLC22A2 | 6582 | 0 | 1 | 10 | |
| GSE74703 | SLC22A2 | 6582 | 4 | 0 | 32 | |
| GSE74704 | SLC22A2 | 6582 | 0 | 2 | 18 | |
| TCGA | SLC22A2 | 6582 | 13 | 22 | 61 |
Total number of gains: 47; Total number of losses: 61; Total Number of normals: 380.
Somatic mutations of SLC22A2:
Generating mutation plots.
Highly correlated genes for SLC22A2:
Showing top 20/512 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC22A2 | MAPK4 | 0.790752 | 3 | 0 | 3 |
| SLC22A2 | TAF1 | 0.728134 | 3 | 0 | 3 |
| SLC22A2 | ADIPOQ | 0.722316 | 3 | 0 | 3 |
| SLC22A2 | C1QL1 | 0.714267 | 3 | 0 | 3 |
| SLC22A2 | PSG7 | 0.705715 | 4 | 0 | 4 |
| SLC22A2 | SCGN | 0.704003 | 3 | 0 | 3 |
| SLC22A2 | CAPN11 | 0.703626 | 3 | 0 | 3 |
| SLC22A2 | ADAMTS12 | 0.691691 | 4 | 0 | 4 |
| SLC22A2 | IFT122 | 0.685996 | 3 | 0 | 3 |
| SLC22A2 | ZMAT4 | 0.681325 | 4 | 0 | 3 |
| SLC22A2 | BIRC7 | 0.675112 | 3 | 0 | 3 |
| SLC22A2 | HTR6 | 0.673241 | 3 | 0 | 3 |
| SLC22A2 | GRID2 | 0.670555 | 4 | 0 | 4 |
| SLC22A2 | COL4A3 | 0.669703 | 5 | 0 | 4 |
| SLC22A2 | CST8 | 0.6669 | 5 | 0 | 5 |
| SLC22A2 | C6orf15 | 0.666659 | 3 | 0 | 3 |
| SLC22A2 | OR52A1 | 0.666444 | 4 | 0 | 4 |
| SLC22A2 | MYL7 | 0.660149 | 3 | 0 | 3 |
| SLC22A2 | ADAM22 | 0.659314 | 5 | 0 | 4 |
| SLC22A2 | GC | 0.657956 | 3 | 0 | 3 |
For details and further investigation, click here
