| Full name: grainyhead like transcription factor 3 | Alias Symbol: SOM | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 57822 | HGNC ID: HGNC:25839 | Ensembl Gene: ENSG00000158055 | OMIM ID: 608317 |
| Drug and gene relationship at DGIdb | |||
Expression of GRHL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRHL3 | 57822 | 232116_at | -0.8112 | 0.5098 | |
| GSE26886 | GRHL3 | 57822 | 232116_at | -4.0147 | 0.0000 | |
| GSE45670 | GRHL3 | 57822 | 232116_at | -0.6968 | 0.0079 | |
| GSE53622 | GRHL3 | 57822 | 157955 | -1.8190 | 0.0000 | |
| GSE53624 | GRHL3 | 57822 | 157955 | -2.5694 | 0.0000 | |
| GSE63941 | GRHL3 | 57822 | 232116_at | 1.8971 | 0.0352 | |
| GSE77861 | GRHL3 | 57822 | 232116_at | -1.3596 | 0.0102 | |
| GSE97050 | GRHL3 | 57822 | A_23_P52067 | -0.3462 | 0.4603 | |
| SRP007169 | GRHL3 | 57822 | RNAseq | -2.8724 | 0.0000 | |
| SRP008496 | GRHL3 | 57822 | RNAseq | -2.7529 | 0.0000 | |
| SRP064894 | GRHL3 | 57822 | RNAseq | -2.5441 | 0.0000 | |
| SRP133303 | GRHL3 | 57822 | RNAseq | -2.5358 | 0.0000 | |
| SRP159526 | GRHL3 | 57822 | RNAseq | -2.8497 | 0.0005 | |
| SRP219564 | GRHL3 | 57822 | RNAseq | -3.5410 | 0.0008 | |
| TCGA | GRHL3 | 57822 | RNAseq | 1.1048 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 10.
Survival by GRHL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRHL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRHL3 | 57822 | 0 | 5 | 25 | |
| GSE20123 | GRHL3 | 57822 | 0 | 4 | 26 | |
| GSE43470 | GRHL3 | 57822 | 2 | 6 | 35 | |
| GSE46452 | GRHL3 | 57822 | 5 | 1 | 53 | |
| GSE47630 | GRHL3 | 57822 | 8 | 3 | 29 | |
| GSE54993 | GRHL3 | 57822 | 2 | 1 | 67 | |
| GSE54994 | GRHL3 | 57822 | 11 | 4 | 38 | |
| GSE60625 | GRHL3 | 57822 | 0 | 0 | 11 | |
| GSE74703 | GRHL3 | 57822 | 1 | 4 | 31 | |
| GSE74704 | GRHL3 | 57822 | 0 | 0 | 20 | |
| TCGA | GRHL3 | 57822 | 10 | 23 | 63 |
Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.
Somatic mutations of GRHL3:
Generating mutation plots.
Highly correlated genes for GRHL3:
Showing top 20/1375 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRHL3 | GDPD3 | 0.855972 | 7 | 0 | 7 |
| GRHL3 | MALL | 0.850627 | 8 | 0 | 8 |
| GRHL3 | CYSRT1 | 0.848198 | 6 | 0 | 6 |
| GRHL3 | S100A16 | 0.836915 | 8 | 0 | 8 |
| GRHL3 | EVPL | 0.834792 | 9 | 0 | 8 |
| GRHL3 | SPRR2F | 0.832703 | 4 | 0 | 4 |
| GRHL3 | C10orf99 | 0.831253 | 6 | 0 | 6 |
| GRHL3 | GRHL1 | 0.827145 | 9 | 0 | 9 |
| GRHL3 | ZNF750 | 0.826565 | 9 | 0 | 8 |
| GRHL3 | SPRR2A | 0.824852 | 4 | 0 | 4 |
| GRHL3 | NCCRP1 | 0.824579 | 4 | 0 | 4 |
| GRHL3 | VSIG10L | 0.822555 | 7 | 0 | 7 |
| GRHL3 | TMEM154 | 0.819381 | 8 | 0 | 8 |
| GRHL3 | TGM1 | 0.818291 | 8 | 0 | 8 |
| GRHL3 | SPRR2D | 0.818045 | 4 | 0 | 4 |
| GRHL3 | FUT3 | 0.817666 | 8 | 0 | 8 |
| GRHL3 | GPR157 | 0.8171 | 7 | 0 | 7 |
| GRHL3 | ZNF185 | 0.814691 | 8 | 0 | 8 |
| GRHL3 | NAGK | 0.813937 | 6 | 0 | 6 |
| GRHL3 | TMPRSS11E | 0.8117 | 7 | 0 | 7 |
For details and further investigation, click here
